Correlation of blood biomarkers with early-onset seizures after an acute stroke event

Abraira, Laura; Giannini, Nicola; Santamarina, Estevo; Cazorla, Sonia; Bustamante, Alejandro; Quintana, Manuel; Toledo, Manuel; Grau-López, Laia; Jiménez, Marta; Ciurans, Jordi; Becerra, Juan Luís; Millán, Mònica; Cardona, Pere; Terceño, Mikel; Zaragoza, Josep; Cánovas, David; Gasull, Teresa; Ustrell, Xavier; Rubiera, Marta; Dávalos, Antoni; Montaner, Joan; Álvarez-Sabín, José

doi:10.1016/j.yebeh.2019.106549

Cited by 24 publications

(40 citation statements)

References 26 publications

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“…On the other hand, it is possible that patients at higher risk of epilepsy may have downregulated baseline levels and an impaired response to brain insults. Hence, in contrast to our early onset seizures findings, 14 the present results may reflect a poor brain response to repair brain damage rather than acute neuroinflammation. 38,39 In addition, we decided to combine both types of stroke after obtaining similar results in a stratified analysis for the ischemic group.…”

Section: Discussioncontrasting

confidence: 99%

“…We found that reduced S100B and Hsc70 levels, and elevated endostatin levels were associated with a greater risk of epilepsy at long term. Our results provide additional information to that obtained in our previous study, focused on early onset poststroke seizures, in which an association was found between this event and two markers in the acute phase of stroke: decreased TNF‐R1 and increased NCAM levels 14 …”

Section: Discussionsupporting

confidence: 79%

“…12,13 Our group found an association between early poststroke seizures and higher neural cell adhesion molecule (NCAM) levels and lower tumor necrosis factor (TNF)-R1 levels. 14 Recently, the group of Zelano investigated the dynamics of blood markers in early onset seizures and epilepsy after mechanical thrombectomy 15 . Nonetheless, the current understanding of brain inflammation and whether these molecules are involved in stroke-related epilepsy is still limited.…”

Section: Key Pointsmentioning

confidence: 99%

“…The biomarker analyses were performed using immunoassays, as described. 14 All techniques were carried out following the manufacturers' instructions by operators blinded to the clinical diagnoses. All samples were tested in duplicate with a coefficient of variation (CV) <20%.…”

Section: Biomarker Analysismentioning

confidence: 99%

“…Some of these inflammatory molecules have been evaluated as biomarkers in several pathogenic processes 12,13 . Our group found an association between early poststroke seizures and higher neural cell adhesion molecule (NCAM) levels and lower tumor necrosis factor (TNF)‐R1 levels 14 . Recently, the group of Zelano investigated the dynamics of blood markers in early onset seizures and epilepsy after mechanical thrombectomy 15 .…”

Section: Introductionmentioning

confidence: 99%

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Blood biomarkers predictive of epilepsy after an acute stroke event

et al. 2020

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Objective: Blood biomarkers have not been widely investigated in poststroke epilepsy. In this study, we aimed to describe clinical factors and biomarkers present during acute stroke and analyze their association with the development of epilepsy at long term. Methods: A panel of 14 blood biomarkers was evaluated in patients with ischemic and hemorrhagic stroke. Biomarkers were normalized and standardized using Zscores. Stroke and epilepsy-related variables were also assessed: stroke severity, determined by National Institutes of Health Stroke Scale (NIHSS) score, stroke type and cause, time from stroke to onset of late seizures, and type of seizure. Multiple Cox regression models were used to identify clinical variables and biomarkers independently associated with epilepsy.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 79%

Section: Key Pointsmentioning

confidence: 99%

Section: Biomarker Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Blood biomarkers predictive of epilepsy after an acute stroke event

et al. 2020

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Seizures after Ischemic Stroke: A Matched Multicenter Study

Ferreira‐Atuesta

Döhler

Erdélyi-Canavese

et al. 2021

Annals of Neurology

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The purpose of this study was to identify risk factors for acute symptomatic seizures and post-stroke epilepsy after acute ischemic stroke and evaluate the effects of reperfusion treatment. Methods: We assessed the risk factors for post-stroke seizures using logistic or Cox regression in a multicenter study, including adults from 8 European referral centers with neuroimaging-confirmed ischemic stroke. We compared the risk of post-stroke seizures between participants with or without reperfusion treatment following propensity score matching to reduce confounding due to treatment selection. Results: In the overall cohort of 4,229 participants (mean age 71 years, 57% men), a higher risk of acute symptomatic seizures was observed in those with more severe strokes, infarcts located in the posterior cerebral artery territory, and

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