Correlation of Blood Lipid and Serum Inflammatory Factor Levels With Hypertensive Disorder Complicating Pregnancy

Abstract

PurposeTo explore the changes of blood lipid and serum inflammatory factors in pregnant women with hypertensive disorder complicating pregnancy (HDP) and the relationship with disease development.Methods107 pregnant women with HDP who had regular prenatal examination in our hospital from July 2018 to July 2021 were selected as the research objects. According to the severity of the disease, they were divided into gestational hypertension group, mild preeclampsia group and severe preeclampsia group. 30 healthy pregnant women who underwent prenatal examination in the same period were selected as the healthy group. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein-associated phospholipaseA2 (Lp-PLA2), C- reactive protein (CRP), interleukin -6 (IL-6), tumor necrosis factor-α (TNF-α) were measured. Receiver operating characteristic curve (ROC) was used to analyze the predictive value of blood lipid and serum inflammatory factors in pregnant women with HDP.ResultsThe levels of serum TC, TG and LDL-C increased with the progression of HDP, the level of serum HDL-C decreased with the progression of HDP (P < 0.05). The levels of serum Lp-PLA2, CRP, IL-6 and TNF-α increased with the progression of HDP (P < 0.05). The AUC of serum TC, TG, HDL-C and LDL-C levels for predicting HDP were 0.759, 0.854, 0.770 and 0.785, respectively. The AUC of serum Lp-PLA2, CRP, IL-6 and TNF-α levels for predicting HDP were 0.873, 0.991, 0.966 and 0.999, respectively.ConclusionThe levels of blood lipid and serum inflammatory factor are closely related to HDP, which has certain value in predicting the occurrence and development of HDP.

A Meta-Analysis of the Differences in Serum Lipid Levels between Pregnant Women with Hypertensive Disorder Complicating Pregnancy and Nonhypertensive Disorder Complicating Pregnancy

“…Hypertensive disorder of pregnancy (HDCP) is a unique pregnancy disorder, which is a group of diseases coexisting with pregnancy and hypertension [ 1 ]. Although a lot of research work has been done at home and abroad on the etiology and pathogenesis of the disease, the exact etiology and pathogenesis of the disease are still uncertain so far [ 2 ].…”

Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway

“…Also, a recent article has disclosed higher levels of IL-6, TNF-α, and hs-CRP in uncomplicated hypertension [ 36 ]. TC, TG, and LDL-C serum levels are increased whereas HDL-C serum levels are decreased with the progression of hypertensive disorder complicating pregnancy (HDP) [ 37 ]. Another study has unveiled that elevated TC, LDL-c, and non-HDL-c are related to hypertension incidence in Chinese adult males [ 38 ].…”

Vaginal microecological imbalance and expression of serum inflammatory factors in pregnant women with group B streptococcus infection and pregnancy outcome

“…Therefore, pregnant women should have regular prenatal examinations to ensure that the levels of inflammatory factors in the serum are normal and reduce the risk of elevated serum inflammatory factors. GBS infection is one of the common infections in pregnant women, which can lead to health problems of the fetus and mother in severe cases (26). Vaginal microecological imbalance is an important factor in GBS infection, so the study of the relationship between vaginal microecology and GBS infection is of great significance for the prevention and treatment of GBS infection (22).…”