Correlation of bone mineral density with biochemical markers in post menopausal women

Agrawal, Swati; Jain, Anju; Mahajan, Damodar K.; Chitra, R.

doi:10.1007/s12291-009-0049-3

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…Some of the markers of bone turnover are mentioned in Tables 2 and 3. Recently, two studies have shown that BAP and NTx are related to changes in bone density and are predictors of rate of bone loss after menopause [22,23]. In a study published in 2010, the associations between bone formation and resorption, micronutrient intake and BLLs were studied in women between 20 and 86 years who had participated in NHANES 1999-2002.…”

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confidence: 99%

Lead as a Risk Factor for Osteoporosis in Post-menopausal Women

Manocha¹,

Srivastava²,

Bhargava³

2016

Ind J Clin Biochem

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Lead exposure is increasingly becoming an important risk factor for osteoporosis. In adults, approximately 80-90 % of absorbed lead is stored in the bones. These bone lead deposits are released into the blood during periods of enhanced bone resorption like menopause, forming a potential endogenous source of lead exposure. Postmenopausal women are at a higher risk for bone lead release because of hormonal and age related changes in bone metabolism. Estrogen deficiency is associated with increase in osteoclasts number and activity leading to both the early and late form of osteoporosis. Hence, high blood lead level coupled with concomitant environmental exposure exposes women in this age group to lead related adverse outcomes like hypertension, reduced kidney and neurocognitive functions as well as increased risk of atherosclerosis and cardiovascular mortality. A few studies have also identified coexisting variates like ethnicity, occupation, residence, education, smoking, alcohol medications, water etc. as significant determinants of bone and blood lead in women, thus increasing the magnitude of postmenopausal bone changes. Hence, interventions focused on reducing the intensity of bone resorption during menopause will help decrease exposure to endogenous lead. This would play a significant role in decreasing the morbidity and mortality associated with menopause. Also, identification of modifiable factors that prevent bone lead release will reduce the risk of chronic lead exposure and improve the health outcomes of post-menopausal women.

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confidence: 99%

Lead as a Risk Factor for Osteoporosis in Post-menopausal Women

Manocha¹,

Srivastava²,

Bhargava³

2016

Ind J Clin Biochem

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“…The quality of life of women after menopause is one of the key health issues today (Agrawal et al, 2009). There are growing evidences for the importance of nutrition in the maintenance of bones and joints health.…”

Section: Resultsmentioning

confidence: 99%

Biochemical Bone Indices and Serum Uric Acid Changes in Postmenopausal Women

Dawood¹

2013

RJS

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The objective of this study was to evaluate the effect of menopause on: body mass index (BMI), serum levels of total protein, albumin, globulin, total calcium, uric acid, activity of acid phosphatase (ACP) and tartarate-resistant acid phosphatase (TRACP 5b). The study involves 50 participants who were categorized into two groups; premenopausal women group (n=25) (age, 47.18 ±4.10 years) and postmenopausal women group (n=25) (age, 58.58 ±4.51years). In comparative evaluation, the serum total protein, calcium, uric acid, activity of ACP and TRACP 5b were found to be significantly increased (p<0.05) in post menopausal women as compared to premenopausal women. Postmenopausal women are exposed to a greater risk of serum biochemical changes as compared to the premenopausal women, thus leading to an increased risk of osteoporosis and cardiovascular diseases after menopause.

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“…High bone turnover rate seems to play an increasing role as a determinant of bone mass with increasing postmenopausal age.As Hydroxy proline forms 16% of bone matrix, the increase in bone turnover after menopause will show increase in urinary excretion of Hydroxy proline which is proved in our study and consistent with other studies. 6,7…”

Section: Discussionmentioning

confidence: 99%