Correlation of Carotid Intimal-Medial Thickness With Estimated Glomerular Filtration Rate and Cardiovascular Risk Factors in Patients of Chronic Kidney Disease

Sikri, Tejinder; Chander, Ramesh; Singh, Phool; Kumar, Sunil; Singh, Kunal; Agarwal, Saurabh; Kumar, Pankaj; Singh, Jeffrey M.

doi:10.14260/jemds/2017/47

jemds

2017

DOI: 10.14260/jemds/2017/47

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Correlation of Carotid Intimal-Medial Thickness With Estimated Glomerular Filtration Rate and Cardiovascular Risk Factors in Patients of Chronic Kidney Disease

Tejinder Sikri¹,

Ramesh Chander²,

Phool Singh³

et al.

Abstract: BACKGROUNDChronic Kidney Disease (CKD) is associated with premature mortality, decreased quality of life and increased health care expenditures. 1,2 Many patients with CKD have cardiovascular disease and die prematurely from this condition instead of surviving long enough to face dialysis or transplantation. 3,4 Carotid Intimal-Medial Thickness (CIMT) predicts future vascular events in the general population. However, the correlation of traditional cardiovascular risk factors and estimated glomerular filtratio… Show more

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Cited by 2 publications

References 26 publications

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Clinical Importance of Markers of Renal Dysfunction in Cardio-Vascular Risk Stratification

Murkamilov,

Aitbaev,

Murkamilova

et al. 2018

Evrazijskij kardiologičeskij žurnal

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Purpose of the study. To study the significance of cystatin C of blood plasma and its relationship with central arterial pressure and carotid intima-media thickness (CIMT) in the stratification of cardiovascular risk.Materials and methods. A general clinical and laboratory examination of 206 patients aged 16 to 88 years was performed, of which men were 101 (49%), women - 105 (51%). The mean age of the examined subjects was 51.8±14.3 years. Lipid spectrum parameters [total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C)], cystatin C, plasma uric acid and fibrinogen were studied. Glomerular filtration rate (GFR) was calculated using the F.J. Hoek et al. (2003) formula. To assess the central blood pressure, all patients underwent a contour analysis of the pulse wave on the AngioScan-01 (AngioScan-Electronics, Russia) and ultrasound examination of carotid artery (CA) on Vivid Q (USA). The type of research was single-step cross-sectional. Depending on the content of cystatin C of the blood plasma, all the examined subjects were divided into three groups. Group 1 (n=62) consisted of patients with cystatin C concentration of up to 0.99 mg/l; group 2 (n=91) - from 1.0 mg/l to 1.5 mg/l; group 3 (n=53) - over 1.51 mg/l.Results. Patients with excessive body weight, stable angina, type 2 diabetes, cerebrovascular diseases (CVD) and chronic glomerulonephritis (CGN) significantly prevailed in group 3, in comparison with groups 1 and 2 (p<0.5). Mean levels of systolic and central blood pressure (BP) were significantly higher in patients from group 3 (p<0.05). In the same group, there was a significant decrease in HDL cholesterol level (p<0.05), an increase in TG concentration (p<0.05), and blood plasma uric acid (p<0.05), as well as CIMT. Statistically and clinically significant decrease in GFR and an increase in the level of cystatin C in blood plasma was noted both in groups 2 and 3 (p<0.05). Positive correlation between CIMT and the level of cystatin C of blood plasma (r=0.578, p<0.05) and negative correlation with the value of GFR (r=-0.556, p<0.05) were recorded among the patients of group 1. In group 2, strong correlation was observed between CIMT and the content of HDL cholesterol plasma (r=-0.343; p<0.05). A significant direct relationship between CIMT and systolic level (r=0.482, p<0.05) and central arterial pressure (r=0.479, p<0.05) was found in individuals from group 3.Conclusion. Studying the content of cystatin C of blood plasma in conjunction with determination of GFR is a priority for early diagnosis of renal dysfunction and assessment of cardiovascular disorders, providing stratification of groups of cardiovascular risk and subsequent implementation of preventive measures to reduce the level of total cardiovascular risk.

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Clinical Importance of Markers of Renal Dysfunction in Cardio-Vascular Risk Stratification

Murkamilov,

Aitbaev,

Murkamilova

et al. 2018

Evrazijskij kardiologičeskij žurnal

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Serum interleukin-18 and carotid intima-media thickness in patients with type 2 diabetes mellitus

Shazly

El-Refaee

Kader

et al. 2020

The Scientific Journal of Al-Azhar Medical Faculty, Girls

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Background Interleukin-18 (IL-18), known as a member of IL-1 family cytokines, is found to be elevated as a part of the chronic low-grade inflammatory process in obesity, metabolic syndrome, and type 2 diabetes (T2D). Patients with carotid intima-media thickness (CIMT) exhibited a higher level of IL-18 in the serum. Objective To study the relation between serum IL-18 and CIMT in patients with type 2 diabetes mellitus (T2DM). Patients and methods A total of 60 patients diagnosed as having T2D and 30 age-matched and sex-matched patients as a control group were recruited in this study. Diabetic patients were divided into two groups according to the presence or absence of diabetic nephropathy. Clinical examination and laboratory investigations including serum IL-18 (by ELISA) and CIMT of both common carotid arteries were carried out. Results Mean serum IL-18 level was significantly increased in patients with T2DM when compared with the control group. There was a significant increase in the mean serum IL-18 in patients with diabetic nephropathy compared with those patients without nephropathy. Moreover, there was a significant positive correlation between serum IL-18 and CIMT, glycated hemoglobin, serum lipids, creatinine, urea, and urinary protein in patients with T2DM (group I) (P<0.001). Conclusion Serum IL-18 level and CIMT were higher in T2DM than that in controls and in diabetic patients with nephropathy compared with those without nephropathy. Higher serum IL-18 levels correlated with larger CIMT, suggesting a role of IL-18 in atherosclerosis.

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Correlation of Carotid Intimal-Medial Thickness With Estimated Glomerular Filtration Rate and Cardiovascular Risk Factors in Patients of Chronic Kidney Disease

Cited by 2 publications

References 26 publications

Clinical Importance of Markers of Renal Dysfunction in Cardio-Vascular Risk Stratification

Clinical Importance of Markers of Renal Dysfunction in Cardio-Vascular Risk Stratification

Serum interleukin-18 and carotid intima-media thickness in patients with type 2 diabetes mellitus

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