Correlation of Catheterized and Clean Catch Urine Protein/Creatinine Ratios in Preeclampsia Evaluation

Chen, Beatrice A.; Parviainen, Kristiina; Jeyabalan, Arun

doi:10.1097/aog.0b013e3181827c89

Cited by 12 publications

(13 citation statements)

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“…uPCRs were highest within 6 hours of delivery after labor. Consistent with previous reports [ 13 ], uPCR measurements were similar regardless of the method of urine sample collection (catheterization or clean catch) among women with intact membranes and no visible vaginal bleeding. A negative or trace urine dipstick result was not reliable to exclude uPCR ≥ 0.3.…”

Section: Discussionsupporting

confidence: 91%

“…Strengths of this study include the prospective study design allowing repeated measurements of uPCRs over time to reveal changes in proteinuria during labor and delivery. The study size (n = 93 with 284 samples collected) is similar to or larger than other relevant studies of uPCR [ 4 , 6 , 13 ]. Finally, the focus on healthy women with low-risk, uncomplicated pregnancies at term allows characterization of normal physiology as relates to proteinuria during labor and delivery.…”

Section: Discussionmentioning

confidence: 99%

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Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study

et al. 2016

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PurposeTo evaluate the utility of urine protein/creatinine ratio (uPCR) measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital.MethodsSerial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multiple imputation and paired sampled analysis was performed when appropriate.ResultsTwo-thirds (63/93) of women had at least one measured uPCR ≥ 0.3. One-third (31/93) had a uPCR ≥ 0.3 at admission, including 39.1% (9/23) of women not in labor. Median (IQR) uPCRs increased during labor and after delivery: latent phase/no labor, 0.15 (0.06–0.32); active phase, 0.29 (0.10–0.58); early postpartum, 0.45 (0.18–1.36) (all p < 0.04). Median uPCRs were significantly < 0.3 in the latent phase and significantly > 0.3 in the immediate postpartum period (p < 0.01). Women who labored before cesarean delivery had the highest early postpartum uPCRs: median (IQR) 1.16 (0.39–1.80). A negative urine dipstick protein result did not exclude uPCR ≥ 0.3. uPCRs were similar when compared by method of urine collection.ConclusionuPCR ≥ 0.3 is common among healthy women with uncomplicated pregnancies at term. uPCR increases during labor and is not a reliable measure of pathologic proteinuria at term or during the peripartum period.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study

et al. 2016

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“…Other studies suggest that it is the presence of proteinuria rather than the severity, which is associated with poorer outcomes. There is evidence that even the finding of trace proteinuria in pregnant women with hypertension is associated with an increase in adverse outcome [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Indicators of Moderate and Severe Preeclampsia in Correlation with Maternal IL10

Markova¹,

Hadzi-Lega²,

Mijakoski³

2016

Open Access Maced J Med Sci

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AIM:The purpose of the actual study was to evaluate the relationship between the formation of anti-inflammatory cytokine IL10 and several indicators of moderate and severe preeclampsia in the third trimester of pregnancy.MATERIAL AND METHODS:Examination of the indicators of preeclampsia and maternal IL10 levels was conducted in 50 women with pregnancies complicated by varying degrees of preeclampsia in the third trimester of gestation as well as in 50 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. The levels of IL10 were determined with a commercial test developed by Orgenium Laboratories (Finland), using reagents from AviBion ELISA research kits. Patients with preeclampsia were categorized into moderate and severe preeclampsia group according to the degree of preeclampsia. Logistic regression analysis was used to determine the predictive value of different parameters for the occurrence of severe preeclampsia. Odds ratios and 95% Confidence Intervals were calculated in order to quantify independent associations.RESULTS:The regression analysis detected systolic blood pressure (160 mmHg or higher), diastolic blood pressure (100 mmHg or higher), persistent proteinuria in pregnancy, serum LDH concentration (450 U/L or higher) and reduced serum concentrations of IL10 as significant predictors of severe preeclampsia in pregnant women after adjusting for age.CONCLUSION:The findings of significantly lower serum IL10 concentrations in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe preeclampsia.

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“…According to the mentioned criteria, 60 women were excluded from the study. According to the ACOG criteria, women were diagnosed with preeclampsia if they had blood pressure ≥140/90 mmHg after 20 weeks of gestation with +1 proteinuria in the urine sample [4,13]. All of the women received information about the purpose of the study and provided an informed consent at the first interview.…”

Section: Study Populationmentioning

confidence: 99%

“…New evidence indicates an association between periodontal diseases and increased risk of systemic diseases such as atherosclerosis, myocardial infarction, stroke, diabetes mellitus, and adverse pregnancy outcomes such as premature birth, low birth weight, miscarriage, and preeclampsia [2,3]. The American College of Obstetricians and Gynecologists (ACOG) has defined preeclampsia as blood pressure >140/90 mmHg and/or ≥1+ proteinuria on a catheterized urine specimen [4]. Preeclampsia is a common pregnancy complication, affecting 7% to 10% of pregnant women, and it has remained one of the two leading causes of maternal mortality worldwide [5,6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Association Between Maternal Periodontal Health and Preeclampsia

Ahmadi

Lor²,

Sayar

et al. 2018

J Islam Dent Assoc Iran

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Background and Aim: Preeclampsia is a considerable complication of pregnancy. Chronic inflammations such as periodontitis may lead to a transient low-grade bacteremia in the maternal-fetal circulation, inducing systemic immune responses, placental abnormalities, and other clinical manifestations of preeclampsia. There are inconsistent findings regarding the correlation between periodontitis and preeclampsia. The aim of this study was to compare periodontal parameters in preeclamptic and normotensive pregnant women. Materials and Methods: This case-control study was conducted among pregnant women visiting Akbarabadi Teaching Hospital, Tehran, Iran, for specialized care during 2015-16. From among 260 pregnant women, 100 with gestational hypertension were selected as the case group, and 100 without gestational hypertension were recruited as the control group. The examined periodontal parameters included Probing Depth (PD), Clinical Attachment Loss (CAL), Bleeding on Probing (BOP), and Plaque Control Record (PCR). The participants' demographic data, prenatal history, and family history were collected through interviewing and assessing their medical records. Data were analyzed by Mann-Whitney U test. Results: Although there were significant statistical differences between the groups with regards to the mean ± standard deviation (SD) of PD (P<0.0001), CAL (P<0.0001), PCR (P=0.001), and BOP (P=0.016) indices, yet the differences were clinically smaller than 0.3 mm and could not be measured with a periodontal probe. Also, the percentage of periodontal diseases was 98% in preeclamptic women and 93% in normotensive women (P=0.17). Conclusion: The present study did not support the theory of the relationship between periodontal parameters and preeclampsia.

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Correlation of Catheterized and Clean Catch Urine Protein/Creatinine Ratios in Preeclampsia Evaluation

Abstract: Clean catch and catheterized urine specimens correlate well in women with suspected preeclampsia. Routine catheterization of pregnant women is not necessary in the evaluation of preeclampsia.

Cited by 12 publications

References 13 publications

Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study

Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study

Indicators of Moderate and Severe Preeclampsia in Correlation with Maternal IL10

Evaluation of the Association Between Maternal Periodontal Health and Preeclampsia

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