Correlation of CD4+ CD25+ Foxp3+ Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis

Sy, Guo; Yj, Ding; L, Li; Zhang, T; Zz, Zhang; Es, Zhang

doi:10.4238/2015.july.3.4

Cited by 11 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the frequency of CD4 + CD25 + Foxp3 + Treg cells has been found to be elevated in the blood of OA patients, OA patients show lower IL-10 secretion from Treg cells and fewer Tim-3 + Treg cells in the blood (78). Similarly, in a rat model of OA induced by the injection of papain and l -cysteine into the right knee joint, the percentage of CD4 + CD25 + Foxp3 + Treg cells in the peripheral blood was significantly lower in the OA rats than in the control rats (68). …”

Section: T Cells and Oamentioning

confidence: 99%

“…However, later observations suggested otherwise. In a rat model of OA induced by the injection of papain and l -cysteine into the right knee joint, the OA rats were found to have a higher serum IL-17 level than the control rats (68). In addition, in a study with 25 OA patients and 13 healthy controls, the number of circulating Th17 cells and the level of serum IL-17 were found to be significantly higher in patients with OA than in healthy controls (47).…”

Section: T Cells and Oamentioning

confidence: 99%

See 1 more Smart Citation

T Cells in Osteoarthritis: Alterations and Beyond

et al. 2017

View full text Add to dashboard Cite

Although osteoarthritis (OA) has been traditionally regarded as a non-inflammatory disease, reports increasingly suggest that it is inflammatory, at least in certain patients. OA patients often exhibit inflammatory infiltration of synovial membranes by macrophages, T cells, mast cells, B cells, plasma cells, natural killer cells, dendritic cells, granulocytes, etc. Although previous reviews have summarized the knowledge of inflammation in the pathogenesis of OA, as far as we know, no report review our current understanding about T cells, especially, each T cell subtype, in the biology of OA. This review highlights the current understanding of the role of T cells in the pathogenesis of OA, with attention to Th1 cells, Th2 cells, Th9 cells, Th17 cells, Th22 cells, regulatory T cells, follicular helper T cells, cytotoxic T cells, T memory cells, and even unconventional T cells (e.g., γδ T cells and cluster of differentiation 1 restricted T cells). The findings highlight the importance of T cells to the development and progression of OA and suggest new therapeutic approaches for OA patients based on the manipulation of T-cell responses.

show abstract

Section: T Cells and Oamentioning

confidence: 99%

Section: T Cells and Oamentioning

confidence: 99%

T Cells in Osteoarthritis: Alterations and Beyond

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Surprisingly, CD4 þ Treg cells percentage decreased after the cycle of mud therapy in OA patients. There have been previous observations of raised levels of circulating CD4 þ Treg cells in OA [42][43][44], but paradoxically, despite elevated numbers of these cells, inflammation is still present in this pathology. This can be understood as an attempt of the immune system to control the inflammatory responses, but the persistence of inflammation could indicate that these cells present functional impairment that limits their capacity to suppress ongoing disease, perhaps due to an inhibition of their suppressive functions by proinflammatory cytokines or because of an increased number of activated effector T cells [44,45].…”

Section: Discussionmentioning

confidence: 85%

Innate/inflammatory bioregulation and clinical effectiveness of whole-body hyperthermia (balneotherapy) in elderly patients with osteoarthritis

Gálvez

Torres-Piles

Ortega

2018

International Journal of Hyperthermia

View full text Add to dashboard Cite

Objectives: Balneotherapy with mud application (mud therapy) is a common hydrothermal intervention for the treatment and rehabilitation of elderly patients with osteoarthritis, leading to anti-inflammatory effects. The main purpose of this investigation was to study a role for regulatory T cells in these anti-inflammatory effects. The second objective was to assess whether the neutrophil-mediated innate response is affected by these anti-inflammatory effects. Methods: Thirty-six elderly patients with knee osteoarthritis underwent a 10-day cycle of balneotherapy at a spa center. They received daily sessions of whole-body mud therapy at 40-42 C, using mineral-medicinal water and mud. IL-8 and TGF-b serum concentrations, percentage of circulating CD4 þ CD25 þ FOXP3 þ and CD8 þ CD28regulatory T cells, and neutrophil phagocytic capacity were evaluated at baseline and at the end of the intervention. Clinical assessments included knee flexion and extension angle, pain, stiffness, physical function and health-related quality of life. Results: All clinical outcomes significantly improved. Circulating concentrations of IL-8 and TGF-b decreased, which correlated with decreased pain and improved knee flexion, respectively. Percentage of CD4 þ regulatory T cells decreased, whereas CD8 þ regulatory T cells increased. Neutrophil functional capacity increased. Conclusions: Balneotherapy with mud application was effective in the management of osteoarthritis symptoms. The anti-inflammatory effect mediated by cytokines contributed to the improvement in pain and joint function; and changes in the circulating percentage of regulatory T cells seem to be involved in the anti-inflammatory effects. Improvement in neutrophil function after mud therapy reflects an optimal bioregulatory effect on the inflammatory and innate responses.

show abstract

“…Nevertheless OA isn't autoimmune disease like RA, recent studies about OA supported that Treg cells aggregate at joints like RA. Polymorphisms described in FOXP3 promotor cause deficient of Treg cells and in this way immun reactions improve 9,11,23,24,25 . In another study that compared with OA and RA, Treg cells equally tranfers to synovial membrane and synovial fluid in joints both of OA and RA and Treg aggregation is not spesific to artritis with inflammation 26 .…”

Section: Discussionmentioning

confidence: 99%

“…It is unknown that which genetic changes, which alignment and whether single or not have contributed to the onset or development of OA 8 . It is suggested that inflammation which seen in synovial membranes in OA, triggers inflammationpromoting mediators 9 . In study of rheumatoid arhritis (RA), one of the autoimmune diseases, it has been determined that variations in the FOXP3 (transcription factor forkhead box P3) promoter region linked with inflammation increase the risk of the disease 10 .…”

Section: Introductionmentioning

confidence: 99%

FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population

Çekin¹,

Pınarbaşı²,

Dönmez³

et al. 2017

Cumhuriyet Medical Journal

View full text Add to dashboard Cite

SUMMARYObjective: In this study we aimed to find out whether FOXP3 promoter region -3499A/G polymorhism was associated with osteoarthiritis in a Turkish population. Method: The study group consists of 50 patients in 3rd stage and 100 patients in 4th stage osteoarthiritis and control group consists of 150 healthy individuals. FOXP3 genotypes were examined by PCR-RFLP method. Results: Our results show that there is no statisticially significant association between osteoarthiritis and FOXP3 -3499A/G polymorphism. The wild type AA genotype was 63%, polymorphic AG was 31% and GG was 6% in the control group, while they were 56%, 37% and 7% in the study group respectively. Conclusions: Osteoarthiritis was seen higher in women than that of men in our study which is compatible with the results of previous results. Keywords: FOXP3, Osteoarthritis, promoter, polymorphism ÖZET Amaç: Bu çalışmada FOXP3 geni promotor bölgesi -3499A/G polimorfizmi ile osteoartrit riski arasındaki ilişki bir Türk popülasyonunda araştırılmıştır. Yöntem: Çalışma grubu, 3. evre 50 ve 4. evre 100 OA hastasından, kontrol grubu ise 150 sağlıklı bireyden oluşmuştur. FOXP3 genotipleri PCR-RFLP yöntemleri kullanılarak elde edilmiştir. Bulgular: Sonuçlarımız istatistiksel olarak OA riski ve FOXP3 geni promotor bölgesi -3499A/G polimorfizmi arasında anlamlı bir ilişki olmadığını göstermiştir. Kontrol grubunda doğal tip AA genotipi %63, polimorfik AG %31 ve GG genotipi oranı % 6 bulunurken çalışma gurubunda bu oranlar sırasıyla %56, %37 ve %7 olarak bulunmuştur. Sonuç: Kadınlarda erkeklere oranla daha sık gözlenmiştir ve bu gözlem, önceki çalışmalarda elde edilen sonuçlar ile uyumludur.

show abstract

Correlation of CD4+ CD25+ Foxp3+ Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis

Cited by 11 publications

References 9 publications

T Cells in Osteoarthritis: Alterations and Beyond

T Cells in Osteoarthritis: Alterations and Beyond

Innate/inflammatory bioregulation and clinical effectiveness of whole-body hyperthermia (balneotherapy) in elderly patients with osteoarthritis

FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population

Contact Info

Product

Resources

About