Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients

Mottaghy, Felix M.; Keller, Christian; Gangitano, Massimo; Ly, Jennifer; Thall, Mark; Parker, J. Anthony; Pascual‐Leone, Álvaro

doi:10.1016/s0925-4927(02)00032-x

Cited by 152 publications

(85 citation statements)

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“…Although some studies report increased dorsolateral metabolic activities after successful treatment, 19,[51][52][53] in line with other HFrTMS interventions, 54 in our study successful HFrTMS treatment resulted in no significant metabolic changes in this area. It may be possible that the limited duration of HF-rTMS treatment was too short to induce metabolic changes in the DLPFC: in a 99mTc-HMPAO SPECT study, Catafou and colleagues 55 reported in a comparable HF-rTMS design that the magnitude of rCBF changes was <10% in all cerebral regions and ~3% in the prefrontal cortex.…”

Section: Discussionsupporting

confidence: 83%

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

Baeken¹,

Raedt

Hove³

et al. 2009

CNS spectr.

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Section: Discussionsupporting

confidence: 83%

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

Baeken¹,

Raedt

Hove³

et al. 2009

CNS spectr.

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“…Another four studies were not included because they had no sham group (Daskalakis et al, 2008;Imm et al, 2008;Mottaghy et al, 2002;Oliveri et al, 2001). Regarding the n-back task, Meiron et al (2012) used a modified n-back version; Andrews et al…”

Section: Overviewmentioning

confidence: 99%

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Brunoni

Vanderhasselt

2014

Brain and Cognition

567

411

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Recent studies have used non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), to increase dorsolateral prefrontal cortex (DLPFC) activity and, consequently, working memory (WM) performance.. However, such experiments have yielded mixed results, possibly due to small sample sizes and heterogeneity of outcomes. Therefore, our aim was to perform a systematic review and metaanalyses on NIBS studies assessing the n-back task, which is a reliable index for WM. From the first data available to February 2013, we looked for sham-controlled, randomized studies that used NIBS over the DLPFC using the n-back task in PubMed/MEDLINE and other databases. Twelve studies (describing 33 experiments) matched our eligibility criteria. Active vs. sham NIBS was significantly associated with faster response times (RT), higher percentage of correct responses and lower percentage of error responses. However, meta-regressions showed that tDCS (vs. rTMS) presented an improvement only in RT. This could have occurred in part because almost all tDCS studies employed a crossover design (possibly more employed in tDCS over rTMS due to the reliable tDCS blinding) -this factor (study design) was also associated with no improvement in correct responses in the active vs. sham groups. To conclude, rTMS over the DLPFC significantly improved all measures of WM performance whereas tDCS significantly improved RT, but not the percentage of correct and error responses. Mechanistic insights on the role of DLPFC in WM are further discussed, as well as how NIBS techniques could be used in neuropsychiatric samples presenting WM deficits, such as major depression, dementia and schizophrenia.

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“…Following 5-10 days of rTMS treatment applied over the left MDLFC, a number of investigators have also found changes in neural activity in the left prefrontal cortex (Speer et al, 2000;Catafau et al, 2001;Nahas et al, 2001) as well as in affectrelevant brain regions, including the anterior cingulate cortex (ACC), amygdala, and striatum (Teneback et al, 1999;Speer et al, 2000;Nahas et al, 2001;Nadeau et al, 2002). Finally, as with antidepressant drugs (eg Mayberg et al, 1997), baseline resting cerebral blood flow and cerebral glucose metabolism values in the ACC have been found to be predictive of antidepressant response to rTMS treatment Mottaghy et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…In a typical protocol, depressed patients are scanned with single photon emission computed tomography (SPECT) or positron emission tomography (PET) before and after rTMS applied over the left MDLFC (1-20 Hz frequency, 1-10 sessions, MDLFC defined as 5 cm anterior to the hand area of the primary motor cortex, eg Kimbrell et al, 1999;Teneback et al, 1999;Speer et al, 2000;Catafau et al, 2001;Nahas et al, 2001;Conca et al, 2002;Mottaghy et al, 2002;Nadeau et al, 2002;Shajahan et al, 2002). Following a single session of high-frequency rTMS, Shajahan et al (2002) reported that the connectivity between a number of brain circuits implicated in affect was significantly stronger.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Action Underlying the Effect of Repetitive Transcranial Magnetic Stimulation on Mood: Behavioral and Brain Imaging Studies

Barrett

Della‐Maggiore

Chouinard

et al. 2004

Neuropsychopharmacol

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In a set of experiments, we applied 10-Hz repetitive transcranial magnetic stimulation (rTMS) over the left mid-dorsolateral frontal cortex (MDLFC) to investigate rTMS-induced changes in affective state and neural activity in healthy volunteers. In Experiment 1, we combined 10-Hz rTMS with a speech task to examine rTMS-induced changes in paralinguistic aspects of speech production, an affect-relevant behavior strongly linked to the ACC. In Experiment 2, we combined 10-Hz rTMS with positron emission tomography (PET) and used partial least squares (PLS) to identify a pattern of brain regions whose connectivity with the site of stimulation varied as a function of rTMS. The results of Experiment 1 revealed that following stimulation of the left MDLFC, subjects reported having less positive affect and vitality and displayed more monotonous speech. In Experiment 2, results revealed that 10-Hz rTMS influenced the covariation between blood flow at the site of stimulation (ie the left MDLFC) and blood flow in a number of affect-relevant brain regions including the perigenual anterior cingulate gyrus, insula, thalamus, parahippocampal gyrus, and caudate nucleus. Taken together, our results suggest that changes in affect and affect-relevant behaviour following 10-Hz rTMS applied over the left MDLFC may be related to changes in neural activity in brain regions widely implicated in affective states, including a frontocingulate circuit.

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Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients

Cited by 152 publications

References 50 publications

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Mechanisms of Action Underlying the Effect of Repetitive Transcranial Magnetic Stimulation on Mood: Behavioral and Brain Imaging Studies

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Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients

Cited by 152 publications

References 50 publications

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from18FDG-PET Brain Imaging

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from18FDG-PET Brain Imaging

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Mechanisms of Action Underlying the Effect of Repetitive Transcranial Magnetic Stimulation on Mood: Behavioral and Brain Imaging Studies

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HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging

HF-rTMS Treatment in Medication-Resistant Melancholic Depression:Results from¹⁸FDG-PET Brain Imaging