Correlation of Choline/Creatine and Apparent Diffusion Coefficient values with the prognostic parameters of Head and Neck Squamous Cell Carcinoma

Abstract

The aim of this study was to measure choline/creatine (Ch/Cr) levels through (1)H-MRS and apparent diffusion coefficient (ADC) values through diffusion-weighted MRI, and to correlate these values with the prognostic parameters of head and neck squamous cell carcinoma (HNSCC). The institutional review board approved this study and informed written consent was obtained from all study participants. A prospective study of 43 patients (31 men and 12 women; mean age, 65 years) with HNSCC was conducted. Single-voxel (1)H-MRS was performed at the tumor or metastatic cervical lymph node with point-resolved spectroscopy (PRESS) at TE = 135 ms. Diffusion-weighted MR images with b values of 0, 500 and 1000 s/mm(2) and contrast MRI of the head and neck were performed. The Ch/Cr levels and ADC values of HNSCC were calculated. The gross tumor volume (GTV) was also calculated. The degree of tumor differentiation was determined through pathological examination. The HNSCC Ch/Cr level was negatively correlated with the ADC value (r = -0.662, p = 0.001). There was a significant difference in the Ch/Cr and ADC values at different degrees of tumor differentiation (p = 0.003 and p = 0.001) and with different GTVs (p = 0.122 and p = 0.001). The following prognostic parameter categories were used: (i) poorly differentiated and undifferentiated versus well differentiated to moderately differentiated; and (ii) HNSCC with GTV < 30 cm(3) versus GTV > 30 cm(3). The cut-off values for Cho/Cr and ADC for each category were 1.83, 0.95 and 1.94, 0.99, respectively, and the areas under the curve were 0.771, 0.967 and 0.726, 0.795, respectively, for each category. We conclude that the Ch/Cr levels determined using (1)H-MRS and the ADC values are well correlated with several prognostic parameters of HNSCC.

Assessment of lacrimal glands in thyroid eye disease with diffusion-weighted magnetic resonance imaging

“…First, this study used diffusion-weighted MR imaging. Further studies with multi-parametric MR imaging [26][27][28][29][30][31][32][33][34] with reduced volume of view and monitoring the patients after therapy [35,36] are needed in the future. Second, ROI was applied for calculation of the ADC value.…”

Whole-body diffusion-weighted imaging with background body signal suppression in the detection of osseous and extra-osseous metastases

“…Third, this study applies diffusion-weighted imaging on 1.5-Tesla scanners. Further studies applied to diffusion tensor imaging combined with other sequences of MR such as arterial spin labelling on higher 3-Tesla scanners will improve the results in the future [35][36][37][38][39][40][41][42][43][44][45][46].…”

Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience

“…In recent years, studies by Razek have shown that ADC metric has a prognostic value in HNSCC[29-31]. They reported a mean ADC value in nasopharyngeal carcinoma (NPC) of 0.99 ± 0.11 × 10 -3 mm 2 /s.…”

“…In a separate study by the same group, it was reported that the mean ADC value of residual or recurrent lesions (1.17 ± 0.33 × 10 -3 mm 2 /s) was less than that observed in post-therapeutic changes (2.07 ± 0.25 × 10 -3 mm 2 /s)[30]. They also showed that ADC values with metabolic ratio (Ch/Cr) obtained from 1H-MRS are well correlated with several prognostic parameters of HNSCC[31]. …”