Correlation of Cholinesterase Levels to Lung Function in Farmer Exposed by Organophosphate Pesticides in Sukorambi Village, Jember Regency

Sandra, Puput Sagita Mey; Sofiana, Kristianningrum Dian; Sutejo, Ika Rahmawati

doi:10.19184/ams.v5i2.9651

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…The use of personal protective equipment (PPE), personal hygiene, and spraying time were found to be factors in the prevalence of acute pesticide poisoning or health problems such as excessive fatigue, excessive salivation, hard breathing, frequent urination, blurred vision, dizziness, and finger pain, according to research by Joko et al (10) on onion farming workers in the Central Java Province of Indonesia. Similar information was obtained from the Sandra et al (11) study findings, which showed a relationship between lung function and acetylcholinesterase levels in the blood of farmers exposed to chronic organophosphate exposure; the lower the level of acetylcholinesterase, the lower the lung function. Pesticides are also known to cause multiple myeloma, sarcoma, prostate and pancreatic cancer, uterine, pancreatic, and Hodgkin's diseases, among other health issues (12)(13)(14).…”

Section: Introductionsupporting

confidence: 82%

Working Hours and Personal Protective Equipment Effect on Blood Cholinesterase Levels of Tobacco Plantation Workers

Ningrum,

Nurika,

Al Mamun

et al. 2024

MJMHS

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Introduction: Tobacco production is increasing in certain regions of Indonesia due to its high economic value. Tobacco and its products can have harmful effects on the health of consumers, producers and processing workers. Analysis of blood samples has shown that tobacco farmers are at risk of developing occupational diseases related to pesticide exposure and nicotine absorption through the epidermis of wet tobacco leaves. The aim of this study was to compare blood cholinesterase levels in tobacco plantation workers in relation to their working hours and use of personal protective equipment (PPE). Methods: This cross-sectional observational study was conducted in ten subdistricts in Jember district, Indonesia, and included 50 participants selected using proportional sampling. Spearman’s test was used to analyse the relationship between variables. Results: The significance value of the relationship based on Spearman’s test between working hours and blood cholinesterase levels of tobacco farmers in Jember was 0.058 > α (0.05). Meanwhile, the significance value of the relationship between working hours and complete blood count, specifically mean corpuscular haemoglobin concentration (MCHC), was 0.00 < α (0.05), and between PPE use and blood cholinesterase levels was 0.035 < α (0.05). Conclusion: Working hours were not associated with blood cholinesterase levels, but were associated with blood MCHC levels. Meanwhile, the use of PPE was found to be associated with cholinesterase levels in tobacco farmers.

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Section: Introductionsupporting

confidence: 82%

Working Hours and Personal Protective Equipment Effect on Blood Cholinesterase Levels of Tobacco Plantation Workers

Ningrum,

Nurika,

Al Mamun

et al. 2024

MJMHS

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“…If the farmer's cholinesterase enzyme levels, normal cholinesterase levels in men are 4620-11500 U/L, while in women they are 3930-10800 U/L. Cholinesterase levels are interpreted as intoxication if cholinesterase activity in the blood decreases by more than 50% of normal or 3500 U/L (13).…”

Section: Cite This Asmentioning

confidence: 99%

“…Cholinesterase levels are used as a marker of pesticide exposure (13). Normal values of cholinesterase for women were 3999-10800 U/L and for men 4620-11500 U/L.…”

Section: Cholinesteration Levelsmentioning

confidence: 99%

“…Pulmonary function test results showed that four patients had restrictive lung disease associated with decreased cholinesterase levels. This is because organophosphates affect the parasympathetic cholinesterase levels (13). A study conducted in an agricultural area found that farmers had lower levels of thyroid-stimulating hormone (TSH), triiodothyronine (T 3 ), and thyroxine (T 4 ) than those who had never been exposed to pesticides (35).…”

Section: Impact Of Poisoning Organophosphatementioning

confidence: 99%

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Literature Review: Impact of Organophosphate Pesticide Exposure on Cholinesterase Enzyme Activity and Associated Risk Factors for Poisoning, 2017-2020

Wicaksono,

Eka Saul Manuel,

Pawitra

et al. 2023

JKL

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Introduction: Organophosphate pesticides, which are used to control pests of crops, affect the nervous system by inhibiting the activity of cholinesterase enzymes in the body. This can be achieved by inhaling, eating, or applying it to the skin. This study research aims to determine the level of pesticide exposure that can inhibit the activity of the Cholinesterase enzyme in the blood. This study employed a systematic literature review with library sources used through Google Scholar and Science Direct, resulting in 16 research articles discussing cholinesterase enzyme activity due to exposure to organophosphates discussed in 2017-2020. Discussion: The results of a previous study found that exposure to organophosphates significantly reduced cholinesterase enzyme activity by 50-80%. Testing for cholinesterase as a biomarker of exposure to Organophospate (OP) through acetylcholinesterase activity in red blood cells (AChE). This study explored the relationship between gender, age, knowledge of farmers, personal protective equipment, farmers’ smoking behavior, and duration of spraying. Conclusion: Poisoning alters the activity of cholinesterase enzymes in the blood of farmers, resulting in acute and chronic health problems. Several factors have been found to correlate with organophosphate poisoning, including age, level of knowledge among farmers, use of personal protective equipment, smoking behavior, and duration of spraying activities.

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Correlation of Cholinesterase Levels to Lung Function in Farmer Exposed by Organophosphate Pesticides in Sukorambi Village, Jember Regency

Cited by 2 publications

References 5 publications

Working Hours and Personal Protective Equipment Effect on Blood Cholinesterase Levels of Tobacco Plantation Workers

Working Hours and Personal Protective Equipment Effect on Blood Cholinesterase Levels of Tobacco Plantation Workers

Literature Review: Impact of Organophosphate Pesticide Exposure on Cholinesterase Enzyme Activity and Associated Risk Factors for Poisoning, 2017-2020

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