Correlation of choroidal thickness and ametropiain young adolescence

Shao, Xiaolei; Zou, Chang; Qin, Bo

doi:10.1371/journal.pone.0174385

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…All of them conclude that the SFCT is positively associated with the SE, being thinner in myopia groups. Their mean SFCT was ranged from 245 µm to 287 µm, [18][19][20][21] which is slightly thinner than our mean.…”

Section: Subfoveal Choroidal Thicknesscontrasting

confidence: 67%

Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

Del-Prado-Sánchez

Seijas

Gili-Manzanaro

et al. 2020

European Journal of Ophthalmology

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Purpose: To study the subfoveal choroidal thickness (SFCT), macular ganglion cell layer (GCL-IPL) and central macular thickness (CMT) in Caucasian children, and to analyze these optical coherence tomography (OCT) parameters depending on the spherical equivalent (SE). Methods: Cross-sectional study of SFCT, GCL-IPL, and CMT in Caucasian children, analyzed with spectral-domain OCT Cirrus 5000 and Enhanced-depth imaging technique. Correlation between these three OCT parameters, age, sex, and spherical equivalent was analyzed. The eyes were classified into three groups: group 1 included eyes with SE < 0, group 2 included eyes with SE between 0 and +2.00, and group 3 eyes with SE > +2.00. Results: Hundred ninety-eight eyes of 121 subjects were studied. The mean age was 9.22 years (range 3–16); 61.1% were female. The mean SFCT was 351.04 ± 84.08 µm, being 310.04 ± 82.84µm in group 1 (n = 62), 373.14 ± 83.16 µm in group 2 (n = 71) and 365.18 ± 73.16 µm in group 3 ( n = 65); statistically significant differences were found between groups 2 and 3, compared with group 1. GCL-IPL thickness was significantly thinner ( p < 0.001) in group 1, compared with group 3. There were no statistically significant differences between the three groups regarding CMT. Correlation with age, and sex was not found. Conclusions: SFCT and GCL-IPL thickness were significantly thinner ( p < 0.001) in myopic children when compared with a non-myopic pediatric population. However, it seems that there is not a correlation among the three OCT parameters studied, age and sex, when they are analyzed depending on refractive error.

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Section: Subfoveal Choroidal Thicknesscontrasting

confidence: 67%

Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

Del-Prado-Sánchez

Seijas

Gili-Manzanaro

et al. 2020

European Journal of Ophthalmology

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“…In this study, the choroidal thickness showed a characteristic distribution pattern and different diopters had different effects on the choroidal distribution (p < 0.01), which is consistent with previous research (20)(21)(22)(23)(27)(28)(29)(30)(31). Song et al studied choroidal thickness in 82 patients with high myopia (15), the results showed that the thickest choroid was observed in the temporal periphery (192.31 ± 25.39 μm), while the thinnest choroid was found in the inferior periphery (154.45 ± 25.37 μm).…”

Section: Discussionsupporting

confidence: 92%

Choroidal thickness in relation to diopter and axial length among myopic children

Zhu,

Liu,

Gao

et al. 2023

Front. Med.

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PurposeThe aim of this study was to analyze the relationship between diopter (D) and choroidal thickness in myopic children by describing the values of choroidal thickness, and explore choroidal thickness as an important indicator for evaluating the progression of myopia.MethodsThe study included myopic and emmetropic children aged 6–14 years (156 eyes) from the Second Hospital of Dalian Medical University. The participants were divided into four groups according to the spherical equivalent refraction (SER): low myopes, moderate myopes, high myopes, and emmetropes. Choroidal thickness was measured in nine areas using the Early Treatment Diabetic Retinopathy Study (ETDRS) grid layout, which divided the areas into concentric circles of 0 × 0 mm, 3 × 3 mm, and 5 × 5 mm from the Sub Fovea. The images were obtained manually with spectral-domain optical coherence tomography scanner.ResultsThere were significant differences of choroidal thickness in the nine areas of the ETDRS grid for all myopes. The distribution of choroidal thickness in low and moderate myopes were different from that in high myopes. In the horizontal direction, choroidal thickness decreased from the temporal to nasal areas for all myopes. In the vertical direction, the choroidal thickness in the perifovea was smaller than that in the parafovea (SER ≥ −2.75D), and the choroidal thickness in the perifovea was greater than that in the parafovea (SER < −2.75D). When comparing emmetropes with myopes, the closer the choroidal thickness was to the central fovea, the more significant the differences were, while the differences were smaller to the perifovea. Among all children, choroidal thickness was positive to SER and negative to axial length (AL) in all areas. For every 1D increase in myopia, the subfoveal choroidal thickness decreased by 13 μm, and for every 1 mm increase in AL, the subfoveal choroidal thickness decreased by 23 μm. Furthermore, SER and AL showed the strongest correlation with choroidal thickness in the inferior area.ConclusionOptical coherence tomography results revealed choroidal thickness was thinner in myopic children. Choroidal thickness was positive to SER and negative to AL. Therefore, we consider choroidal thickness to be an important indicator for evaluating the myopia progress.

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“…The results of this study show that there is a weak negative correlation between age and choroidal thickness in all directions of both eyes (r absolute value is less than 0.3) at the age of 7-18 years. However, in some large sample studies [30] , choroidal thickness in this age group has a signi cant negative correlation with age. There are also some studies showing [26] that when the age is less than 60, choroidal thickness has no obvious correlation with age, but when the age is more than 60 years old, there is a negative correlation.…”

Section: Discussionmentioning

confidence: 76%

“…Previous studies have shown that choroidal thickness is negatively correlated with age [27,29,30] . The results of this study show that there is a weak negative correlation between age and choroidal thickness in all directions of both eyes (r absolute value is less than 0.3) at the age of 7-18 years.…”

Section: Discussionmentioning

confidence: 94%

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Exploration of a new method in measurement of choroidal thickness in children and teenagers by EDI-OCT

Liu

Lü

et al. 2022

Preprint

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Purpose: Using EDI-OCT and combining it with a self-built program to achieve choroidal thickness measurement in a simple and easy way. Measurement and analysis of choroidal thickness in normal children and adolescents. Methods: Twenty healthy volunteers (40 eyes) were randomly recruited. The choroidal images of healthy volunteers were obtained by EDI-OCT mode. The anterior choroidal boundary (Bruch membrane) was automatically generated by Heidelberg software. At the same time, the posterior choroidal boundary was manually depicted with the drawing tool in OCT software. A program was written to calculate choroidal thickness to verify the repeatability of the method. OCT images were collected from 99 children and adolescents aged 7-18 years. These choroidal was measured by the method previously verified. Results: 1. ICC was 0.975, 95% CI was [0.959, 0.984], p≤0.001. 2. The average thickness of the choroid in the horizontal direction is 249.17±68.84μm in the 3mm range, and it was 258.24±69.63μm in the vertical direction. The correlation coefficients of choroidal thickness and axial length in horizontal and vertical directions were -0.642, -0.624 (p≤0.001, p≤0.001). The correlation coefficients between choroid thickness and diopter in horizontal and vertical directions were 0.610, 0.583 (p≤0.001, p≤0.001). Conclusion: 1. The experimental method has good repeatability and can calculate the average thickness of the choroid through pixels. 2. There was a weakly significant correlation between choroidal thickness and age, but significant with axial length and diopter. 3. It is simple to operate, requires low computer knowledge, and can be accepted more easily by clinicians and researchers. And it can be widely used in the field of EDI-OCT.

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Correlation of choroidal thickness and ametropiain young adolescence

Cited by 5 publications

References 25 publications

Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

Choroidal thickness in relation to diopter and axial length among myopic children

Exploration of a new method in measurement of choroidal thickness in children and teenagers by EDI-OCT

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