Correlation of chronic periodontitis progression with sTREM-1 and E-Cadherin salivary levels

Tâlvan, Elena-Teodora; Mohor, Calin; D, Chisnoiu; Făgeţan, I. M.; Tâlvan, Constantin-Dan; Cristea, Victor; Câmpian, Radu Septimiu

doi:10.1515/rrlm-2017-0038

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…The result of this study also revealed decreasing levels of this biomarker along with the stages of periodontitis, and this is in solidity with Tâlvan et al in 2017, 39 where IL-10 levels decreased from early to generalized, being the lowest in aggressive periodontitis; thus, it is tempting to speculate that the higher expression of IL-10 accounts for the less severe form of the disease when compared with the progressed state of periodontitis.…”

Section: Discussionsupporting

confidence: 90%

“…Significantly higher concentration of IL-10 in periodontitis stage I and II comparing it to health was noted; this comes in agreement with Fenol et al who found that IL-10 levels were higher in periodontitis than in health, attributing the results to the severity of the inflammatory process going on providing sufficient stimulus for a positive IL-10 response, 37 likewise, in a study by Varma et al, there was higher IL-10 levels in periodontitis stage I and II compared with health. 38 On the contrary, Tâlvan et al in 2017 39 reported higher levels of this cytokine in health despite differences in study design, samples, and settings, explained by its well-known role in maintaining the health and stability of periodontal tissues.…”

Section: Discussionmentioning

confidence: 98%

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Salivary IL-17 and IL-10 as Potential Diagnostic Biomarkers of Different Stages of Periodontitis in Smoker and Nonsmoker Patients

2023

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Objectives The gold standard in the field of periodontal research currently is to find a valid biomarker that can reliably be used for diagnosing periodontal diseases. Given the limitations of the current diagnostic tools that stall to predict susceptible individuals and determine whether active tissue destruction is occurring, there is an increased urge to develop alternative diagnostic techniques that would compensate for the problems inherited in these available methods, such as measuring levels of biomarkers present in oral fluids such as saliva; so the aim of this study was to determine the diagnostic potential of interleukin-17 (IL-17) and IL-10 to differentiate periodontal health from smoker and nonsmoker periodontitis, and to differentiate among different stages (severities) of periodontitis. Materials and Methods An observational case–control study was performed on 175 systemically healthy participants grouped into healthy as controls and periodontitis as cases. Periodontitis cases were divided according to the severity into stages I, II, and III, and each of the stages was further subdivided into smokers and nonsmokers patients. Unstimulated saliva samples were collected, clinical parameters were recorded, and salivary levels were assayed using enzyme-linked immunosorbent assay. Results Elevated levels of IL-17 and IL-10 were associated with stage I and II compared with the healthy controls. However, a significant decrease in stage III was observed compared with the control group for both biomarkers. Conclusion Salivary IL-17 and IL-10 might be useful for distinguishing periodontal health from periodontitis; however, further research is needed to substantiate their use as potential biomarkers for the diagnosis of periodontitis

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Salivary IL-17 and IL-10 as Potential Diagnostic Biomarkers of Different Stages of Periodontitis in Smoker and Nonsmoker Patients

2023

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“…To the best of our knowledge, investigating the level of this epithelial biomarker in oral fluids for diagnostic purposes has received limited attention. 23 Thus, this study aimed to determine the diagnostic and prognostic capabilities of salivary E-cadherin to differentiate between periodontal health and periodontitis and to discriminate grades of periodontitis.…”

Section: Introductionmentioning

confidence: 99%

“…This study is based on the hypothesis that the level of unbonded E‐cadherin is increased due to destructive inflammatory events associated with periodontitis as compared to healthy periodontium. To the best of our knowledge, investigating the level of this epithelial biomarker in oral fluids for diagnostic purposes has received limited attention 23 . Thus, this study aimed to determine the diagnostic and prognostic capabilities of salivary E‐cadherin to differentiate between periodontal health and periodontitis and to discriminate grades of periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Salivary E‐cadherin as a biomarker for diagnosis and predicting grade of periodontitis

Kazem

Abdulkareem

Milward

2023

J of Periodontal Research

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Objectives To determine the abilities of salivary E‐cadherin to differentiate between periodontal health and periodontitis and to discriminate grades of periodontitis. Background E‐cadherin is the main protein responsible for maintaining the integrity of epithelial‐barrier function. Disintegration of this protein is one of the events associated with the destructive forms of periodontal disease leading to increase concentration of E‐cadherin in the oral biofluids. Materials and Methods A total of 63 patients with periodontitis (case) and 35 periodontally healthy subjects (control) were included. For each patient, periodontal parameters including bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded. Concentration of salivary E‐cadherin was determined by ELISA. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to determine the diagnostic potentials of E‐cadherin. Results Level of salivary E‐cadherin was significantly higher in periodontitis cases than controls. The ROC analysis showed that salivary E‐cadherin exhibits excellent sensitivity and specificity (AUC 1.000) to differentiate periodontal health from periodontitis with a cutoff concentration equal to 1.325 ng/mL. The AUCs of E‐cadherin to differentiate grade A from grade B and C periodontitis were 0.731 (cutoff point = 1.754 ng/mL) and 0.746 (cutoff point = 1.722 ng/mL), respectively. However, the AUC of salivary E‐cadherin to differentiate grade B from grade C periodontitis was lower (0.541). Additionally, BOP and PPD were significantly and positively correlated with the concentration of salivary E‐cadherin. Conclusion Salivary E‐cadherin exhibited excellent sensitivity and specificity to differentiate periodontitis from a healthy periodontium. The level of accuracy of E‐cadherin was also sufficient to recognize grade A periodontitis from grade B and C periodontitis.

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“…[18][19][20] Consistent with this observation, the level of soluble E-cadherin in salivary samples of periodontitis patients was found to be significantly higher than in healthy controls. 21,22 Furthermore, immunohistochemical analysis of periodontally diseased tissue samples demonstrated reduced E-cadherin levels. 16 Successful periodontal therapy outcomes are the goal of appropriately targeted treatment plans.…”

Section: Introductionmentioning

confidence: 99%

Ability of gingival crevicular fluid volume, E‐cadherin, and total antioxidant capacity levels for predicting outcomes of nonsurgical periodontal therapy for periodontitis patients

Hussein,

Abdulkareem,

Milward

et al. 2023

J of Periodontal Research

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ObjectivesTo determine the potential of gingival crevicular fluid (GCF) volume, E‐cadherin and total antioxidant capacity (TAC) levels to predict the outcomes of nonsurgical periodontal therapy (NSPT) for periodontitis patients.BackgroundNSPT is the gold‐standard treatment for periodontal pockets < 6 mm in depth, however, successful outcomes are not always guaranteed due to several factors. Periodontitis‐associated tissue destruction is evidenced by the increased level of soluble E‐cadherin and reduced antioxidants in oral fluids which could be used as predictors for success/failure of NSPT.Materials and MethodsPatients with periodontitis (n = 24) were included in this clinical trial and full‐mouth periodontal charting was recorded for each patient. GCF samples from periodontal pockets with probing pocket depth (PPD) 4–6 mm from the interproximal surfaces of anterior and premolar teeth were obtained. These sites subsequently received NSPT and were clinically re‐evaluated after 1 and 3 months. Levels of GCF E‐cadherin and TAC levels were assayed using ELISA.ResultsAll clinical periodontal parameters were significantly improved 3 months after completion of NSPT. These outcomes were associated with a significant decrease in E‐cadherin levels and GCF volume, while TAC levels were significantly increased in samples obtained in follow‐up appointments. Binary regression model analysis showed that PPD, GCF volume, E‐cadherin, and TAC levels could significantly (p < .05) predict the outcomes of NSPT. The cut‐off points for PPD, GCF volume, E‐cadherin and TAC were 5 mm, 4 × 10−3, 1267.97 pg/mL and 0.09 μmol/g, respectively.ConclusionNSPT improved clinical parameters along with increased antioxidants capacity and epithelial pocket lining integrity. Discrimination of favorable/unfavorable responsiveness of periodontally diseased sites to NSPT could be possible by using GCF volume, PPD, E‐cadherin and TAC level assessments.

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Correlation of chronic periodontitis progression with sTREM-1 and E-Cadherin salivary levels

Cited by 4 publications

References 9 publications

Salivary IL-17 and IL-10 as Potential Diagnostic Biomarkers of Different Stages of Periodontitis in Smoker and Nonsmoker Patients

Salivary IL-17 and IL-10 as Potential Diagnostic Biomarkers of Different Stages of Periodontitis in Smoker and Nonsmoker Patients

Salivary E‐cadherin as a biomarker for diagnosis and predicting grade of periodontitis

Ability of gingival crevicular fluid volume, E‐cadherin, and total antioxidant capacity levels for predicting outcomes of nonsurgical periodontal therapy for periodontitis patients

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