Correlation of Clinical and Dosimetric Parameters With Radiographic Lung Injury Following Stereotactic Body Radiation Therapy

Dose impact in radiographic lung injury following lung SBRT: Statistical analysis and geometric interpretation

“…A recent study has also demonstrated a significant association between volume of radiographic density changes and patient-related parameters such as age, significant smoking history, and GOLD score. 22 Therefore, our study indicates that the HU dose response averaging in previous methods might have resulted in an overgeneralization of the dose response of lung normal tissue post-SBRT. The decrease in single mode cases with respect to time indicates an increase in bimodal behavior as the injury volume develops into chronic fibrosis over time.…”

“…Few studies have specifically examined the relationship between dose and CT changes after SBRT or radiosurgery. Hof et al 9 correlated the contoured radiographic NTC to treatment dose by finding the fractional intersection between lung volumes receiving different dose levels (6)(7)(8)(8)(9)(10)(10)(11)(12)(12)(13)(14)(14)(15)(16)(16)(17)(18)(18)(19)(20)(20)(21)(22)(23)(24)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) and the NTC volume. Our method incorporates the same concept with a more direct approach of simply extracting the differential dose volume distribution of the contoured volume.…”

“…Radiographic normal tissue complication (NTC) after single fraction (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) Gy) radiosurgery had been previously investigated. Hof et al found a significant correlation between radiation dose levels and NTC development in single fraction radiosurgery by correlating the volume of NTC at varying treatment dose levels ranging from 6 to 35 Gy.…”