Correlation of Clinical Symptoms With Nasal Endoscopy and Radiological Findings in the Diagnosis of Chronic Rhinosinusitis: A Prospective Observational Study

Caliaperoumal, Vanitha Brindha Baba; Gs, Dharanya; Velayutham, Prabu; Krishnaswami, Balasubramanian; Krishnan, Krishna Kumar Rama; Savery, Nishanth

doi:10.7759/cureus.16575

Cited by 4 publications

(5 citation statements)

References 28 publications

(41 reference statements)

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“…In this study male to female ratio was 1:1.23 with female preponderance which corresponds to study carried out by Baba Caliaperoumal et al [13] where the male to female ratio was 1:1.18. However, most studies have higher male to female ratios like in a study done by Srivastava et al [14] where male to female ratio was 1.38:1.…”

Section: Discussionsupporting

confidence: 89%

“…Many studies have shown that the correlation between CT scan and DNE findings was very high [15,21,22] . Other studies [13,17] also showed significant correlation between symptom-based criteria and DNE scores and CT scan scores.…”

Section: Discussionmentioning

confidence: 74%

“…In a study done by Agius [18] , the facial pain [50.49%] had prevalence higher when compared to our study. Several studies, also, had nasal obstruction and nasal discharge as the two commonest presenting symptoms [13][14][15][16][17],…”

Section: Discussionmentioning

confidence: 99%

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Correlation of Symptoms of Chronic Rhinosinusitis with Objective Sino Nasal Examination: A Prospective Observational Study

Bhardwaj¹,

Thambidurai²

2023

International Journal of Medical Arts

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Article informationBackground: CT scan and Diagnostic nasal endoscopy [DNE] can both be used in diagnosis and management of Chronic rhinosinusitis [CRS]; however, it has been a matter of debate as to which of these two modalities is effective in terms of cost, ease off doing and better correlation Aim of the work:This study intends to correlate the severity of the symptoms of CRS with DNE and CT scan findings vis-a-vis correlating the scores between the two diagnostic modalities and concluding as to which off them is more effective. Materials and Methods:This was a prospective observational study done at a tertiary teaching hospital. Patients satisfying the diagnostic criteria of CRS by American Academy of Otolaryngology-Head and Neck Surgery were shortlisted for study. The duration of symptoms and severity score of all patients was recorded. All participants were then subjected to CT scan and DNE. The Qualitative and quantitative variables were compared with help of Spearman Rank correlation coefficient test. A p-value of < 0.05 was taken as statistically significant. SPSS version 19.0 was used for analysis.Results: A total of 128 patients diagnosed with CRS participated in the study. There were 56 [43.7%] males and 73 [57.03%] females. Correlation was between all the parameters such as severity score and CT Scan scores, severity score and DNE scores, CT scan scores and DNE scores [right side, left side and bilateral combined] were statistically significant. Conclusion:In the patients who meet the symptoms criteria for diagnosis of CRS had high-level of diagnostic accuracy with both CT scan and DNE. Since both the test and symptoms severity correlates well, doing either one of them will suffice in diagnosis. DNE being readily available in Otolaryngology department can be chosen over CT scan thereby reducing cost and radiation exposure to patient.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 74%

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Correlation of Symptoms of Chronic Rhinosinusitis with Objective Sino Nasal Examination: A Prospective Observational Study

Bhardwaj¹,

Thambidurai²

2023

International Journal of Medical Arts

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“…However, our study findings were at variance to findings of Caliaperoumal et al (2021) in which female preponderance was observed and mean age was also higher. 4 In present study, four cardinal features were noted in majority of cases either on unilateral or bilateral sites. The most common cardinal clinical feature observed in our study was nasal obstruction (94.9%), followed by nasal discharge (61%), hyposmia/ anosmia/ parosmia in 43.2% and facial pain in 29.7% cases.…”

Section: Discussionsupporting

confidence: 55%

Clinical and Radiological Evaluation of Chronic Rhinosinusitis

Baisakhiya¹,

Sharma²,

Maini³

et al. 2023

BJOHNS

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Introduction The diagnosis of rhinosinusitis is based on clinical grounds having characteristic symptoms, combined with objective evidence of mucosal inflammation. We studied the corelation between the symptoms of the patients, clinical and endoscopic findings with CT scan findings in chronic rhinosinusitis (CRS). Materials and Methods Patients above the age of 15yrs fulfilling the criteria of Chronic sinusitis laid by European position paper on rhinosinusitis and nasal polyps (EPOS) 2012 were prospectively studied. Demographic and clinical profile were noted. Diagnostic Nasal Endoscopy was done and findings were recorded. Patients were undergone CT evaluation after giving appropriate medical management. Clinical, endoscopic and radiological findings were compared with similar studies. Data was analysed using IBM SPSS software version 20. Results This study included 118 patients of Chronic Rhinosinusitis. Patients commonly male between the age group of 21-30 years presented with nasal obstruction, headache and nasal discharge in order of presentation. Diagnostic Nasal endoscopy revealed Septal deviation in 64.4% and medialize uncinate process in 15.2% of cases. Nasal discharge (48.3%) was commonest finding. CT scan suggested deviated nasal septum (70.4%), concha bullosa (30.5%), blocked osteo-meatal complex (68.6%) in patients of CRS. Presence of Agger Nasi cell (49.2%), Haller cell (12.7%) and Onodi cell (15.7%) seen in these patients. Conclusion CT scan and diagnostic endoscopy along with detailed clinical examination are essential component for assessment of a patient with chronic rhinosinusitis. CT scan is considered as gold standard but endoscopy is also a valuable tool for diagnostic evaluation of patients with CRS.

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“…The role of epithelial cells in the pathogenesis of CRS has attracted more and more attention. As the first natural barrier to contact external stimuli and an important structure of innate immunity, epithelial cells on the surface of nasal mucosa play an important role in protecting the body from external harmful factors [10][11][12] . Once the epithelial cell barrier function is damaged, it is mainly manifested in epithelial cell abscission and dysfunction in CRS, which will provide conditions for the invasion of external harmful substances, such as bacteria, virus invasion and allergen exposure, so as to cause and aggravate the chronic inflammation of nasal cavity and paranasal sinus mucus membrane and lead to the accumulation of inflammatory cells and inflammatory factors [13,14] .…”

mentioning

confidence: 99%

Triptolide inhibits the Apoptosis and Reactive Oxygen Species Production in Hydrogen Peroxide-Treated Nasal Epithelial Cells by Regulating PTEN/PI3K/AKT Signaling Pathway

Wang¹,

Zhu²,

Guo³

et al. 2022

IJPS

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Wang et al.: Triptolide inhibits the Nasal Epithelial CellsChronic rhinosinusitis is a chronic inflammatory condition that caused by many factors. However, the underlying mechanism of chronic rhinosinusitis remains unclear. The current study focused on the roles of triptolide on hydrogen peroxide treated nasal epithelial cells and the underling mechanism. Hydrogen peroxide treated human nasal epithelial cells were cultured and treated by different concentrations of triptolide, cell growth and cell death were determined by cell counting kit-8 and flow cytometry methods. Moreover, effects of triptolide on expression of superoxide dismutase as well as malondialdehyde in nasal epithelial cells treated by hydrogen peroxide were evaluated by enzyme-linked immunosorbent assay analysis. Furthermore, effects of triptolide on expression of phosphatase and tensin homolog deleted on chromosome 10/phosphatidylinositol 3-kinase/protein kinase B molecules in hydrogen peroxide treated nasal epithelial cells have been examined by Western blot method. We found treatment of hydrogen peroxide markedly inhibited growth of the nasal epithelial cells in dose-dependent manner and triptolide could reverse the effect induced by hydrogen peroxide. Moreover, triptolide significantly decreased the apoptosis of the nasal epithelial cells induced by hydrogen peroxide in dose-dependent manner; moreover, triptolide reduced superoxide dismutase as well as malondialdehyde levels in dose dependent manner. Finally, triptolide downregulated phosphatase and tensin homolog deleted on chromosome 10 and upregulated the phosphatidylinositol 3-kinase related signalling in hydrogen peroxide treated cells in vitro. In conclusion, triptolide may exert anti-apoptotic and anti-oxidative behaviors in chronic rhinosinusitis via affecting phosphatase and tensin homolog deleted on chromosome 10/phosphatidylinositol 3-kinase/protein kinase B signaling. The results of current work study may provide new evidence for the research as well as management of chronic rhinosinusitis.

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Correlation of Clinical Symptoms With Nasal Endoscopy and Radiological Findings in the Diagnosis of Chronic Rhinosinusitis: A Prospective Observational Study

Abstract: Baba Caliaperoumal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 4 publications

References 28 publications

Correlation of Symptoms of Chronic Rhinosinusitis with Objective Sino Nasal Examination: A Prospective Observational Study

Correlation of Symptoms of Chronic Rhinosinusitis with Objective Sino Nasal Examination: A Prospective Observational Study

Clinical and Radiological Evaluation of Chronic Rhinosinusitis

Triptolide inhibits the Apoptosis and Reactive Oxygen Species Production in Hydrogen Peroxide-Treated Nasal Epithelial Cells by Regulating PTEN/PI3K/AKT Signaling Pathway

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