Correlation of coagulation indicators with inflammatory markers in the acute pancreatitis patients

Chooklin, S.; Pidhirnyy, Bohdan

doi:10.1016/j.pan.2016.06.594

Cited by 2 publications

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“…D-dimer is significantly raised in SAP compared to Mild AP. [ 21 ] D-dimer levels increase significantly as CTSI increases ( P = 0.04). All these CTs were done after 72 h in our study as an early CT will not be of help.…”

Section: Discussionmentioning

confidence: 96%

D-dimer as a Marker of Severity and Prognosis in Acute Pancreatitis

Newton

2024

International Journal of Applied &Amp; Basic Medical Research

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Background and Objectives: Acute pancreatitis (AP) scores need a battery of tests that are not helpful at an early stage. Can a single test predict Complicated Acute Pancreatitis (CAP) which includes moderate and severe AP, local complications, and need for intensive care unit (ICU). Methodology: 30 patients of AP. D-dimer, C-reactive protein levels done within 3 days of AP onset. APACHE II, Ranson’s score, CT severity index were done. Inhospital disease course for development of organ failure and need for ICU care was followed daily. Results: D-dimer in CAP was 2732 ng/L (MAP 567 ng/L), in abnormal computed tomography (CT) was 1916 ng/L (normal CT 363 ng/L), and in organ failure was 4776 ng/L (776.5 ng/L absent organ failure). D-dimer increases as the severity of organ failure increases (P = 0.04). D-dimer in ICU patients was significantly elevated (P = 0.021). D-dimer correlates with APACHE II score well, with an increase in predictive mortality rate (P = 0.01). On receiver operator characteristics, D-dimer >933.5 ng/L predicts CAP, >827.5 ng/L predicts positive CT findings (local complications), and >1060.5 ng/L predicts the development of organ failure. Conclusion: Coagulopathy and microthrombi play a significant role in early pathogenesis. D-dimer test acts at the level of this core pathogenesis, even before the complications set in. D-dimer within 72 h of AP correlates well with the CT findings after 72 h. This is the first study that correlates D-dimer levels with CT scores, ICU requirement. D-dimer can guide primary care physicians in selecting AP patients for referral to a higher center in a resource-limited setting.

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Section: Discussionmentioning

confidence: 96%

D-dimer as a Marker of Severity and Prognosis in Acute Pancreatitis

Newton

2024

International Journal of Applied &Amp; Basic Medical Research

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“…[23] начальных фармакологических исследований in vivo и in vitro. Ранее выявленный эффект воздействия соединения L-17 на гемокоагуляционные показатели крови при ОПП, вероятно, связан с его противовоспалительным механизмом действия, что соответствует литературным данным о связи воспалительной реакции и коагулопатических нарушений, развивающихся при остром панкреатите [24][25][26][27][28][29][30][31]. Противовоспалительный эффект соединения L-17 подтвержден положительными изменениями лейкоцитарной формулы, снижением уровня цитокинемии и, что особенно важно, изменением клеточного состава воспалительного инфильтрата поджелудочной железы.…”

Section: Discussionunclassified

Correction of the Inflammatory Reaction in the Discrete Model of Acute Post-manipulation Pancreatitis

Rantsev,

Sarapultsev,

Chupakhin

2024

Урал. мед. журнал

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Introduction. Acute post-manipulation pancreatitis (APP) is a common complication of endoscopic interventions on the major duodenal papilla of the duodenum. Moderate acute pancreatitis develops more often than severe acute pancreatitis.The purpose of the work is to determine the effect of compound L-17 of the group of substituted thiadiazines on the severity of the inflammatory reaction in moderate severity APP.Materials and methods. The severity of the inflammatory reaction in experimental APP after surgery in rats using the compound L-17 was studied. During this study, laboratory indicators of the severity of the inflammatory reaction were assessed, including the leukocyte count and the level of increase in the concentration of the major interleukins. Furthermore, morphological data was analyzed to allow an assessment of the dynamics of the cellular composition of the inflammatory infiltrate of the pancreas in the APP in the experiment.Results. A decrease in the severity of the inflammatory reaction was shown according to leukocyte count, cytokine concentration, and a morphological study of the inflammatory infiltrate of the pancreas.Discussion. The effectiveness of the proposed surgical technique for the formation of APP has been proven by the development of acute pancreatitis in all animals operated. Most experimental methods for acute pancreatitis have no such effectiveness. The data obtained confirm the opinion of numerous authors that interventions on the major duodenal papilla are a risk factor for the development of APP. The study used the compound L-17, which is a representative of a new group of organic compounds, substituted thiadiazines, which have a disaggregant and anticoagulant effect. The effect of compound L-17 on the hemocoagulation parameters of blood is associated with the anti-inflammatory mechanism of action of compound L-17.Conclusion. Administration of compound L-17 in moderate-severity experimental APP can reduce the severity of the inflammatory reaction.

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Correlation of coagulation indicators with inflammatory markers in the acute pancreatitis patients

Cited by 2 publications

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D-dimer as a Marker of Severity and Prognosis in Acute Pancreatitis

D-dimer as a Marker of Severity and Prognosis in Acute Pancreatitis

Correction of the Inflammatory Reaction in the Discrete Model of Acute Post-manipulation Pancreatitis

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