Correlation of coagulation states with prognosis of sudden deafness

Abstract

Prognosis of sudden deafness remains a challenge in clinics due to inhomogeneity of the disease. Here we report our retrospective study aimed to explore the value of coagulative markers including activated partial thromboplastin time (APTT), prothrombin time (PT), plasma fibrinogen (FIB) and plasma D-Dimer in the prognosis of the patients. The study included a total of 160 patients, of which 92 had valid responses, and 68 had invalid responses and 68 had ineffective responses. APTT, PT, and the levels of FIB and D-D in serum were compared between the two groups, and their prognostic values were determined in terms of area-under-curve (AUC) in receiver operating curve (ROC) analysis, sensitivity and specificity. The correlations of APTT, PT and FIB to hearing loss degree were also assessed. Serum APTT and PT, FIB and D-Dimer levels were lower in patients with sudden deafness that responded poorly to treatments. ROC analysis showed that APTT, PT, FIB and D-Dimer had high AUC, sensitivity and specificity for non-responders, particularly when used in combination (AUC=0.91, sensitivity=86.76%, and specificity=82.61%). Patients with a higher hearing loss degree (>91dB) also demonstrated significantly lower values of APTT and PT and higher levels of serum FIB and D-Dimer than those with a lower hearing loss degree. Our study demonstrated that APTT, PT, and serum levels of FIB and D-D could serve as strong predictors of sudden deafness, potentiating the use of these tests to identify patients that respond poorly to treatments.

The psychological intervention and clinical efficacy of Rosenthal effect and acupuncture bleeding on middle-aged and young patients with sudden hearing loss

“…[ 14 ] Li et al [ 15 ] found that the treatment effectiveness of injecting corticosteroid drug dexamethasone into the tympanic cavity was better than that of the CG, and the efficacy of injecting dexamethasone into the tympanic membrane was better. Zhang et al [ 16 ] explored the value of coagulation markers in prognostic analysis of patients with SHL. Research has found that activated partial thromboplastin time and prothrombin time values were lower in patients with moderate hearing loss, and clotting markers could serve as effective predictive indicators for identifying patients with poor prognosis.…”