Correlation of Cochlear Blood Supply with Mitochondrial DNA Common Deletion in Presbyacusis

Dai, Pu; Wei, Yang; Jiang, S; Gu, Rui; Yuan, Huijun; Han, Donghee; Guo, Weiwei; Cao, Juyang

doi:10.1080/00016480410016586

Cited by 50 publications

(37 citation statements)

References 8 publications

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“…Damaged mitochondrial DNA may cause reduced oxidative phosphorylation, which may lead to neural dysfunction in the inner ear. A study by Dai et al [12] also suggested that damaged mitochondrial DNA may lead to anatomic changes of the inner ear, more severe narrowing of the vaso nervorum in the internal auditory meatus in temporal bones with a mitochondrial DNA deletion. Damaged mitochondrial DNA has also been linked to a greater rate of apoptosis of certain cells in the inner ear in a study by Pickles [13].…”

Section: Discussionmentioning

confidence: 99%

“High Frequency Presbycusis”–Is There an Earlier Onset?

Arvin

Prepageran

Raman

2011

Indian J Otolaryngol Head Neck Surg

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The objective of this study is to determine whether presbycusis occurs much earlier than previously believed if the high frequency (above 8 kHz) are included. Tertiary referral center (a teaching University). This is a cross-sectional observational study. Healthy adults from 20 to 49 years of age who had essentially normal hearing were included into the study. They were subjected to high frequency pure tone audiometry (until 16 kHz). Participants were grouped based on age ranges of 10 years (e.g., 20-29, 30-39, and 40-49) and the presence of symmetrical high frequency sensor neural hearing loss were documented. There is a significant presence of symmetrical high frequency sensor neural hearing loss (not attributed to any known risk factors) as early as from the age group of 40 to 49 years. Seven of 43 participants (16%) from age group of 20 to 29 years and 12 of 24 participants (50%) from age group of 30 to 39 years had significant high frequency hearing loss. High frequency hearing loss (high frequency Presbycusis) may occur much earlier than previously believed.

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Section: Discussionmentioning

confidence: 99%

“High Frequency Presbycusis”–Is There an Earlier Onset?

Arvin

Prepageran

Raman

2011

Indian J Otolaryngol Head Neck Surg

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“…One specific mtDNA deletion, mtDNA4,834, has been linked to AHL in rodents [59]. The equivalent mutation, mtDNA4,977, deletion in human has also been identified, using archived temporal bones from patients with presbycusis [60][61][62]. Interestingly, consistent with a causal role for mtDNA mutations in ARHL, mice carrying a mutation in the exonuclease domain of the nucleus-encoded catalytic subunit of the mtDNA polymerase gamma (POLG), accumulated mtDNA mutations and displayed premature onset of ageingrelated phenotypes, including HL [63].…”

Section: Oxidative Stressmentioning

confidence: 99%

Ageing and hearing loss

Yan

2007

The Journal of Pathology

278

178

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Although many adults retain good hearing as they age, hearing loss associated with ageing is common among elderly persons. There are a number of pathophysiolological processes underlying age-related changes to functional components in the inner ear. Genetic factors determine the ageing process but are under the influence of intrinsic and environmental factors. It is difficult to distinguish changes of normal ageing from those of other contributing factors. The effects of age-related deafness can have significant physical, functional and mental health consequences. Although a deficit in hearing can be corrected to some degree by a hearing aid or other appropriate amplification devices, hearing-related rehabilitative needs are much more than simply amplifying external sound. Only by better understanding the process of ageing and its effect on the auditory function can we better accommodate elderly people in our day-to-day interactions. We review here the structure and function of the inner ear, pathophysiology associated with age-related hearing loss (ARHL), heritability, allelism and modifier genes of ARHL, and evaluate the genetic analyses for identification of genetic factors that are involved.

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“…There is also loss of nerve fibres and neural elements. [14] The reduction in blood flow leads to formation of Reactive Oxygen Metabolites (ROM), which affects inner ear structure and damages mitochondrial DNA. [14] Mitochondrial DNA deletions lead to deafness.…”

Section: Discussionmentioning

confidence: 99%

“…[14] The reduction in blood flow leads to formation of Reactive Oxygen Metabolites (ROM), which affects inner ear structure and damages mitochondrial DNA. [14] Mitochondrial DNA deletions lead to deafness. Researchers observed that diminished flow in capillaries of basal turn of cochlea correlates with higher frequency hearing loss in elderly.…”

Section: Discussionmentioning

confidence: 99%

Role of Lycopene in Presbycusis

Singh¹

2015

jemds

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Lycopene a red carotenoid found mainly in tomatoes and few other fruits and vegetables, is said to have strong antioxidant properties. This study aims to evaluate the effect of lycopene supplements in patients with age related hearing loss (Presbycusis) and any symptoms related to it like tinnitus. MATERIALS AND METHODSTwo hundred patients with bilateral symmetrical progressive age related sensorineural hearing loss (Presbycusis) were taken up in the study; 100 patients in study group were given capsule supplement containing lycopene and multivitamins once a day after meals for 12 months. Remaining 100 patients in control group were given capsule supplement containing only multivitamins without lycopene once a day after meals for 12 months. Patients were evaluated using Pure Tone Audiometry (PTA) at first visit, after 6 months and after 12 months for degree of hearing loss, tinnitus and any side effects of capsules in both study and control groups. RESULTSThe results showed that presbycusis mainly effects higher speech frequencies (2000 hertz and above). The results showed that there was slower progression of degree of sensorineural hearing loss in study group using lycopene containing supplement as compared to control group without lycopene. There was a marginal improvement in incidence of tinnitus in the study group. There were minimal drug related side effects like nausea, vomiting and diarrhoea with no difference in both groups with or without lycopene. CONCLUSIONSo it can be concluded that Lycopene supplements can be considered as a safe treatment to slower the progress of disease in patients with age related hearing loss.

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Correlation of Cochlear Blood Supply with Mitochondrial DNA Common Deletion in Presbyacusis

Cited by 50 publications

References 8 publications

“High Frequency Presbycusis”–Is There an Earlier Onset?

“High Frequency Presbycusis”–Is There an Earlier Onset?

Ageing and hearing loss

Role of Lycopene in Presbycusis

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