Correlation of Connexin43 Expression and Late Ventricular Potentials in Nonischemic Dilated Cardiomyopathy

Kitamura, Hidetsuna; Yoshida, Akihiro; Ohnishi, Yozo; Okajima, Katsunori; Ishida, Akihiko; Galeano, Erdulfo J.; Kubo, Shinya; Fukuzawa, Kouji; Takano, Takatsugu; Yokoyama, Mitsuhiro

doi:10.1253/circj.67.1017

Cited by 15 publications

(16 citation statements)

References 36 publications

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“…Patchy interstitial fibrosis adjacent to viable myocardium is commonly seen in dilated cardiomyopathy. Fibrosis decreases electrical coupling, slows the propagation of impulses between myocytes and can become the anatomical substrate for reentrant VT. Alterations of the gap junctions are accompanied by discontinuity of tissue structure, which includes the naturally occurring myocardial cell orientation and the collagen matrix formed by the fibrosis (Kitamura et al, 2003). The expression of connexin 43 was more decreased in patients with late ventricular potentials than in those without LVPs (Kitamura et al, 2003), but the degree of fibrosis seem not to influence the results.…”

Section: Cardiomyopathiesmentioning

confidence: 95%

“…Fibrosis disturbs ventricular activity, separates myocardial bundles and prolongs conduction pathways (Cain et al, 1996). Anisotropic reentry is the result of fibrosis in addition to the density and distribution of gap junctions, which are responsible for variations in the conduction velocity (Kitamura et al, 2003;Peters et al, 1997). Some authors have demonstrated a close link between the distribution of the gap junctions, the specialized intercellular connections, and the development of reentrant arrhythmia in patients with healed MI and nonischemic dilated cardiomyopathy (Kitamura et al, 2003;Peters et al, 1997).…”

Section: Historymentioning

confidence: 99%

“…Anisotropic reentry is the result of fibrosis in addition to the density and distribution of gap junctions, which are responsible for variations in the conduction velocity (Kitamura et al, 2003;Peters et al, 1997). Some authors have demonstrated a close link between the distribution of the gap junctions, the specialized intercellular connections, and the development of reentrant arrhythmia in patients with healed MI and nonischemic dilated cardiomyopathy (Kitamura et al, 2003;Peters et al, 1997). The slow and discontinuous conduction caused by abnormalities in gap junction distribution and function form a functional, rather than anatomical, substrate for reentry (Santangeli et al, 2008).…”

Section: Historymentioning

confidence: 99%

“…Ohnishi et al (Ohnishi et al, 1990 ) and Mancini et al (Mancini et al, 1993) mentioned a high incidence of prospective arrhythmias and SCD in patients with a IDCM and abnormal SAECG. Kitamura et al (Kitamura et al, 2003) concluded that the heterogeneous expression of connexin 43 protein may contribute to impaired ventricular conduction and LVPs detected on SAECG in patients with IDCM. Patchy interstitial fibrosis adjacent to viable myocardium is commonly seen in dilated cardiomyopathy.…”

Section: Cardiomyopathiesmentioning

confidence: 99%

See 3 more Smart Citations

Late Ventricular Potentials in Cardiac and Extracardiac Diseases

Mozoş¹,

Şerban²,

Mihăescu³

2012

Cardiac Arrhythmias - New Considerations

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Section: Cardiomyopathiesmentioning

confidence: 95%

Section: Historymentioning

confidence: 99%

Section: Historymentioning

confidence: 99%

Section: Cardiomyopathiesmentioning

confidence: 99%

See 2 more Smart Citations

Late Ventricular Potentials in Cardiac and Extracardiac Diseases

Mozoş¹,

Şerban²,

Mihăescu³

2012

Cardiac Arrhythmias - New Considerations

View full text Add to dashboard Cite

“…The standard 12-lead ECG and SAECG were recorded before and immediately after administration of dipyridamole using a portable SAECG FDX-6521 (Fukuda Denshi Co Ltd, Tokyo, Japan) (Fig 1). 19,20 The SAECG was recorded with standard 12-lead. The signals from 200 beats were averaged with the conventional R wave-triggering system.…”

Section: Dipyridamole Stress 12-lead Ecg and Saecgmentioning

confidence: 99%

Portable Type Signal-Averaged Electrocardiography With Dipyridamole A New and Convenient Method to Detect Patients With Coronary Artery Disease and Ischemia

Matsumoto

Hiraki

Yoshida

et al. 2005

Circ J

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xercise electrocardiography is frequently used as a diagnostic test for coronary artery disease (CAD). This method takes an advantage of changes in STsegment of a standard electrocardiography (ECG) at the time of myocardial ischemia. It is a non-invasive and relatively simple method, but there are some problems. Because a special device is required, the method cannot be used at the bedside. Nor is it applicable to patients who have orthopedic problems.Previous studies in experimental animals have shown that acute myocardial ischemia results in a decreased conduction velocity of the myocardium. This decreased conduction velocity during myocardial ischemia is manifested as QRS prolongation in the surface ECG. [1][2][3][4][5] Holland and Brooks produced ischemia in the anterior wall of the myocardium after acute ligation of the left anterior descending coronary artery in pigs and demonstrated QRS prolongation. 1 Similar findings were observed in other experimental studies. [2][3][4][5] These reports have demonstrated that extracellular K + at the ischemic area is increased in association with decreased conduction velocity. It is postulated that Circulation Journal Vol.69, June 2005 this regional hyperkalemia delays conduction velocity.Prolonged QRS duration in the standard 12-lead ECG during exercise was demonstrated in CAD patients. [6][7][8][9][10] However, it is difficult to detect subtle changes in the prolongation of QRS interval using the standard 12-lead ECG. The subtle changes in QRS duration can be evaluated using the filtered QRS wave duration (fQRSd) on the signal-averaged ECG (SAECG). 11-15 However, a conventional SAECG recording device is fixed in order to cope with the problem of noise, and the recording is limited to an electrically shielded room. It is difficult to perform a stress test to induce myocardial ischemia of patients with CAD in an electrically shielded room. A portable type SAECG (portable SAECG) maintains a sufficiently low noise level for recording outside the electrically shielded room. As in the case of a standard ECG recording, bedside recording is easily performed and stress inducement is possible.Using this portable SAECG recording device, we investigated whether or not patients with CAD could be easily detected at the bedside using dipyridamole stress. Methods Study PatientsThe study population consisted of 80 patients who had chest pain as their chief complaint and who were hospitalized in the Third Department of Internal Medicine of Kurume University between January 1999 and February Background Whether or not patients with coronary artery disease (CAD) could be easily detected at the bedside using dipyridamole stress was investigated using a portable type signal-averaged electrocardiography (portable SAECG). Methods and ResultsThe standard 12-lead QRS wave SAECG was performed at the bedside before and after dipyridamole stress in 30 patients with angiographically significant stenotic lesions, who had positive myocardial ischemia in the dipyridamole-thallium myocardial perfus...

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