Correlation of cord bilirubin levels with hyperbilirubinaemia in ABO incompatibility.

Risemberg, Herman M.; Mazzi, Eduardo; MacDonald, M G; Peralta, M. M.; Heldrich, Fred J.

doi:10.1136/adc.52.3.219

Cited by 39 publications

(36 citation statements)

References 12 publications

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“…This study reported significant jaundice and anemia through infants with positive direct coombs test. Same results were published by Risembery et al [14].…”

Section: Discussionsupporting

confidence: 77%

Clinical Course and Prognosis of Hemolytic Jaundice in Neonates in North East of Iran

Boskabadi¹,

Maamouri²,

Mafinejad³

et al. 2011

Macedonian Journal of Medical Sciences

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“…This study reported significant jaundice and anemia through infants with positive direct coombs test. Same results were published by Risembery et al [14].…”

Section: Discussionsupporting

confidence: 77%

Clinical Course and Prognosis of Hemolytic Jaundice in Neonates in North East of Iran

Boskabadi¹,

Maamouri²,

Mafinejad³

et al. 2011

Macedonian Journal of Medical Sciences

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“…Risemberg et al al noted a strong associa on of strongly posi ve coombs test with hyperbilirubinaemia in ABO incompa bilty 9 . In Moderately aff ected group 9 (60%) were DCT posi ve out of total 15 babies.…”

Section: Discussionmentioning

confidence: 96%

“…HM Rusemerg et al reported ABO incompa bility in 20-25% of deliveries and ABO haemoly c disease in less than 10% of these cases 9 .…”

Section: Discussionmentioning

confidence: 97%

“…Risemberg observed a strong associa on of cord serum bilirubin of ≥4mg/dl with severe hyperbilirubinemia requiring exchange transfusion necessita ng their placement in centre where frequent evalua on and appropriate therapy are available 9 . Robinsn et.…”

Section: Discussionmentioning

confidence: 99%

“…To target health care resources towards high risk newborns cord bilirubin, 1 st day bilirubin and pre discharge bilirubin values have been used to predict signifi cant hyperbilirubinaemia in healthy term new born to keep a close follow up and plan interven on if needed 4,6,7,8,9 . These studies did not include ABO or RH incompa bility.…”

Section: Introductionmentioning

confidence: 99%

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Cord Serum Bilirubin Level in Predicting the Development of Significant Hyperbilirubinemia in Newborns with ABO Incompatibility

Arora

Shifali

2016

J. Nepal Paedtr. Soc.

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Introduction: Neonatal hyperbilirubinaemia is common problem which is benign in majority of neonates. Rh iso immune hemolytic disease as a cause of hyperbilirubinemia is becoming nearly nonexistent due to the use of prophylactic anti D. Hence Isoimmune hemolytic disease due to ABO incompatibility assumes significance as a cause of significant hyperbilirubinaemia. This study was conducted to determine the incidence of ABO incompatibility, ABO iso immune disease in new born, to determine critical cord serum bilirubin level to predict subsequent significant hyperbilirubinemia. Material and Methods: The study was done in neonatal ICU of a tertiary care hospital where 100 full term healthy newborns with B.W≥2500gm and gestational age ≥37 wk with blood group A, B, AB, born to mothers with O blood group without simultaneous Rh incompatibility at SGRDIMSR were included. Serum bilirubin was measured approximately at 12-24hrs, 36-48hrs, 60-72hrs. Results: Out 100 ABO incompatible newborns 33(33%) developed ABO isoimmune disease manifesting as significant hyperbilirubinaemia with any of the four total serum bilirubin levels exceeding threshold levels defined for phototherapy. TSB of ≥ 2.16mg/d1 from cord blood has a sensitivity of 100% specificity of 89.55%, NPV 100% and PPV of 82.50% to predict significant hyperbilirubinaemia. Conclusion: A critical cord S.bilirubin between 2.16 mg/d1 and 4.09mg/d1 will predict all newborns who will have significant hyperbilirubinaemia and can be used as a safe demarcator to decide time of discharge. Any therapeutic intervention if necessary can be started as early as possible.

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Early diagnosis of ABO haemolytic disease of the newborn

et al. 1987

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To assess the usefulness of cord blood tests in diagnosing ABO-haemolytic disease of the newborn (ABO-HDN), 132 term, adequate for gestational age (AGA) neonates were evaluated. The tests studied and their significant results were: quantitative elution test (greater than or equal to 1/16), direct Coombs test (positive), bilirubin concentration (greater than or equal to 4 mg/dl). In none of the 56 O+ newborn infants delivered by O+ women were the results of any test positive. Of the 76 A+ and B+ newborn infants delivered by O+ women, 17 (22%) developed ABO-HDN. When the combined result of any two tests was positive, the sensitivity, the specificity and the positive predictive accuracy for the diagnosis of ABO-HDN was higher than for any one of the isolated tests. The probability that ABO-HDN was present when the results of at least two cord blood tests were positive was 70%, and the probability that ABO-HDN was not present when less than two cord blood tests gave positive results was 93%. It is suggested that the combination of quantitative elution test, bilirubin concentration and direct Coombs test in the cord blood is useful for an early diagnosis of ABO-HDN.

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Correlation of cord bilirubin levels with hyperbilirubinaemia in ABO incompatibility.

Cited by 39 publications

References 12 publications

Clinical Course and Prognosis of Hemolytic Jaundice in Neonates in North East of Iran

Clinical Course and Prognosis of Hemolytic Jaundice in Neonates in North East of Iran

Cord Serum Bilirubin Level in Predicting the Development of Significant Hyperbilirubinemia in Newborns with ABO Incompatibility

Early diagnosis of ABO haemolytic disease of the newborn

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