Correlation of Cord blood Cardiac Troponin-T to Echocardiographic and Tissue Doppler Variables in Infants of Diabetics Mothers with and without Hypertrophic Cardiomyopathy

Abstract

Objective: The objective was to evaluate the value of cord blood cardiac troponin-T levels and tissue Doppler echocardiography in evaluation of hypertrophic cardiomyopathy in infants of diabetic mothers. Methods:A prospective study involved 60 infants of diabetic mothers and 60 healthy neonates.Cord blood level of cardiac troponin-T was measured and conventional and tissue Doppler echocardiographies were performed for all infants. Results:Hypertrophic cardiomyopathy was present in 19 cases (31.6%) of infants of diabetic mothers. There were significant increase in the cord blood cardiac troponin-T levels (P<0.0001) and more significant systolic and diastolic dysfunction in infants of diabetic mothers than in control group. Infants of diabetic mothers with hypertrophic cardiomyopathy had significant increase in the cord blood cardiac troponin-T levels (P<0.0001) and more significant systolic and diastolic dysfunction than infants of diabetic mothers without hypertrophic cardiomyopathy. There was no significant correlation between infant's birth weight and cord blood cardiac troponin-T levels while there was significant correlation between maternal glycosylated hemoglobin and cord blood levels of cardiac troponin-T. There were significant negative correlation between cord blood levels of cardiac troponin-T and E/A ratio at mitral valve, E'/A' ratio and S wave at mitral annulus, E/A ratio tricuspid valve, E'/A' ratio and S wave at tricuspid annulus. There were positive correlations between cord blood cardiac troponin-T levels with septal/posterior wall, and Tie indices.Conclusion: cardiac troponin-T was a useful marker especially when combined with tissue Doppler echocardiography for evaluation of hypertrophic cardiomyopathy in infants of diabetic mothers. Keywords: