Correlation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconus

Bozkurt, Banu; Yılmaz, Mevlüt; Meşen, Ali; Kamış, Ümit; Köktekir, Bengü Ekinci; Okudan, Süleyman

doi:10.4274/tjo.22800

Cited by 10 publications

(10 citation statements)

References 31 publications

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“…18 However, Bozkurt et al reported that ECD signi cantly decreased with the progression of KC in their study, which consisted of 391 eyes and a mean patient age of 24.2 ± 7.7 years. 10 Goebels et al observed that ECD decreased and CV increased with the progression of keratoconus in their work containing 712 KC cases. 9 Our study comprised only those patients who had not undergone a surgical procedure previously and had no contact lens use history.…”

Section: Discussionmentioning

confidence: 95%

“…Some publications reported lower endothelial cell density (ECD) compared to healthy eyes, whereas others observed no signi cant change. [9][10][11][12] Similarly, several publications in the literature report a decrease in the hexagonal cell percentage (HCP) and an increase in the coe cient of variation (CV) in KC cases, while some studies report no change. [9][10][11][12] Reasons for the different results may be related to the number of patients included in the studies, the distribution of the age range of the patients, the stages of keratoconus, and the previous treatment approaches.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Corneal Endothelium in Middle-Aged Keratoconus Eyes

Dogan¹,

Çakır²,

Aksoy³

et al. 2021

Preprint

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Purpose To investigate the corneal endothelial cell parameters and to evaluate the correlation with corneal topographic parameters in middle-aged non-treated keratoconus (KC) patients. Materials and Methods Thirty-six eyes of 21 KC patients in the middle decade (4th-5th) and age-gender matched 36 healthy eyes were included. Topographic parameters [(K1, K2 Sim K, central, thinnest pachymetry, anterior chamber depth (ACD)] were obtained with Galillei double scheimpflug analyzer. Patients were divided into stages according to mean keratometric values (Mild < 45D,Moderate 45-52D, Severe > 52D, Advanced > 62 D). Endothelial cell density (ECD), coefficient of variation (CV) of cell areas and hexagonal cell percentage (HCP) obtained with specular microscopy were recorded.Corneal topography and specular microscopy parameters were compared between KC and healthy eyes. The correlation between topographic and specular microscopy parameters were analyzed. Results The mean age of the patients was 38.6 ± 6.0 and 37.8 ± 4.2 years in the KC and control group, respectively. Age and gender were statistically similar between the groups. ECD was 2772 ± 17 in the KC group and 2741 ± 30 cells / mm2 in the control group, and there was no statistical difference between the groups (p: 0.621). HCP was 63.5 ± 7.2, 67.4 ± 5.2 in KC and healthy eyes, respectively (p: 0.014); CV was 30.7 ± 5.2 and 28.6 ± 3.4, respectively (p: 0.058). Specular microscopy parameters were not statistically different according to KC stage. K1,K2,SimK, CCT, ACD did not correlate with ECD in patients. Conclusion Our results showed that endothelial cell morphology is significantly affected in middle-aged KC patients who have not been treated.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Evaluation of Corneal Endothelium in Middle-Aged Keratoconus Eyes

Dogan¹,

Çakır²,

Aksoy³

et al. 2021

Preprint

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“… 33 , 34 Bitirgen et al 35 detected a decrease in basal epithelial cells and anterior stromal keratocyte density in corneas affected by KC, but reported no change in posterior stromal keratocyte density, endothelial cell count, or subbasal corneal nerve morphology. Bozkurt et al 36 used corneal topography and noncontact endothelial microscopic data to investigate changes in endothelial density in different stages of KC and determined that endothelial cell count decreased with KC progression.…”

Section: Rigid Gas-permeable Contact Lenses In Keratoconusmentioning

confidence: 99%

Update on Contact Lens Treatment of Keratoconus

Şengör¹,

Kurna²

2020

tjo

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Keratoconus (KC) is a progressive disease that leads to major losses of visual quality and related quality of life. Contact lens (CL) application has a primary place and importance in the correction of the optic problems due to the disease. The corneal changes and increased irregular astigmatism that occur with KC progression necessitate special CL designs and fitting methods. In addition to disease stage, the patient’s lens tolerance also plays a role in the application of CLs in KC patients. With recent advances in materials and design technology, the CLs used in the treatment of KC have developed considerably and there are various types available. In this review, we discuss the wide range of CLs, including rigid and soft lenses, hybrid and scleral lenses, and even custom lens designs, in light of recent scientific advances.

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“…It is characterized by changes in the structures of corneal epithelium and stroma and stromal thinning associated (3). In addition, specular microscopy also revealed some differences in terms of cell number and morphology in the endothelium compared to healthy individuals (6)(7)(8). Glasses and contact lenses are used for visual rehabilitation in keratoconus.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies revealed that ultraviolet rays led to endothelial toxicity and the number of endothelial cells decreased in the patients following the Corneal Cross-Linking Treatment for Keratoconus, especially the ones with less than 400 µm of corneal thickness and underwent epithelial debridement (12,13). Evaluation of endothelial cell counts and morphology before treatment can help determine whether cross-linking treatment will cause endothelial damage or not and what crosslinking modality should be pursued for the patient (8,13). A healthy corneal endothelium is crucial for patients receieving cross-linking treatment in keratoconus, as well as for patients undergoing keratoplasty.…”

Section: Introductionmentioning

confidence: 99%

The Findings of Corneal Specular Microscopy in Patients with Keratoconus

Taşlı¹,

Karakurt²,

Uçak³

et al. 2019

Ann Med Res

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The aim of this study was to determine the correlation of corneal endothelial cell density, coefficient of variation and hexagonal cell ratio with the stages of keratoconus and corneal thickness. Material and Methods: The study included 102 eyes from 51 patients. The corneal topography was performed using the Sirius corneal topographic device and the examination of the endothelium was performed using Nidek CEM-530. The patients were divided into groups in accordance with keratometry values (group 1: K2<45 D, group 2: K2 45-52 D, group 3: K2> 52 D) and thinnest cornea thickness (group 1:> 450 µm, group 2: 400-450 µm, group 3: <400 µm). Specular microscopic findings were compared according to the severity of keratoconus and corneal thickness. Results: Of the patients, 29 (50%) were male and 22 (50%) were female. The mean age was 29.8 ± 7.7 (15-45) years. Endothelial cell count and hexagonal cell ratio were significantly lower in severe keratoconus compared to mild and moderate keratoconus and the coefficient of variation was higher in severe keratoconus compared to the other groups (p <0.001). When the patients were compared according to the pachymetry value at the thinnest point of the cornea, the endothelial cell number and the hexagonal cell ratio were found to be lower in the group with pachymetry less than 400 µm (p <0.001). The coefficient of variation was higher in the same group compared to the others (p <0.001). Conclusion: It was revealed that endothelial cell density, hexagonal cell ratio decreased and the coefficient of variation increased with the progression of keratoconus. Specular microscopic examinations in patients with keratoconus provide important data in addition to topography.

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Correlation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconus

Cited by 10 publications

References 31 publications

Evaluation of Corneal Endothelium in Middle-Aged Keratoconus Eyes

Evaluation of Corneal Endothelium in Middle-Aged Keratoconus Eyes

Update on Contact Lens Treatment of Keratoconus

The Findings of Corneal Specular Microscopy in Patients with Keratoconus

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