Correlation of corneal thickness with blood glucose control in diabetes mellitus

Abstract

The aim of this study was to prove the existence of a correlation between corneal thickness and glycaemic control in insulin-dependent patients. Ultrasound pachometry and blood glucose measurements were taken in 87 patients three times a day: fasting, two, and four hours after lunch. The sample was divided into three groups of patients: 30 of them did not have retinopathy, 30 presented background retinopathy and 27 proliferative retinopathy. Thirty normal age-matched subjects were the control group. No correlation was found between pachometry values, blood glucose and duration of diabetes in the three groups (p > 0.05). A significant increase in corneal thickness was found in patients with background and proliferative retinopathy compared to the others (p < 0.01). No corneal thickness differences resulted between background and proliferative retinopathy (p = 0.74).

Effect of hyperglycemia duration on rabbit corneal thickness and endothelial ATPase activity

“…No significant relationships were found between corneal thickness and blood glucose level (slope = -0.35, p = 0.19, r2 = 0.03). The agreement of the current rabbit data with literature reports of no significant relationship between blood glucose and corneal thickness in Type I diabetic human subjects (Busted et al 1981;Pierro et al 1993), offers further support for the alloxaninduced diabetic rabbit as a useful model for the human diabetic condition.…”

Corneal biomechanical characteristics in patients with diabetes mellitus

“…[1][2][3][4] Studies show that eyes in patients with diabetes have a greater central corneal thickness (CCT) 5,6 and that there is a positive association between CCT and the degree of diabetic retinopathy. 7 Corneal hydration control also appears to be compromised in corneas of diabetic patients, 8,9 and there is evidence that biomechanical properties vary with corneal hydration. 10 The hyperglycemia associated with diabetes mellitus can result in increased protein glycosylation, creating advanced glycosylation end products (AGEs).…”

Evaluation of Central Corneal Thickness Using Spectral-Domain Optical Coherence Tomography in Patients with Diabetes Mellitus

“…24 DR'si olan hastaların korneaları incelendiğinde, retinopatinin ilerlemesi ile MKK'nin arttığı gösterilmiştir. 10,11 Çalışmamızda DR varlığı ile MKK arasında ilişki yok idi. Lee ve ark., DM süresiyle MKK'nin anlamlı olarak arttığını bildirmişlerdir.…”

“…9 Çalışma-larda, diyabet hastalarında merkezi kornea kalın-lığı (MKK)'nın arttığı ve bu artışın DR şiddeti ile ilişkili olduğu gösterilmiştir. 10,11 Kornea kalınlı-ğında ve kornea sertliğinde meydana gelen deği-şiklikler de göz içi basıncı (GİB) ölçümünde değişimlere yol açabilmektedir. Bu durum da diyabetik hastaların glokom tanı ve tedavisinde hatalara neden olabilmektedir.…”