Correlation of elevated levels of lipoprotein(a), high-density lipoprotein and low-density lipoprotein with severity of preeclampsia: a prospective longitudinal study

Konrad, Elena; Güralp, Onur; Shaalan, Waleed; Elzarkaa, Alaa A; Moftah, Reham; Alemam, Doaa; Malik, Eduard; Soliman, Amr A.

doi:10.1080/01443615.2019.1603214

Cited by 20 publications

(23 citation statements)

References 26 publications

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“…During pregnancy, the greatest challenge associated with potential lipid disorders is significant up to 2.5× physiological increase in triglycerides in the second, and in particular the third trimester of pregnancy, which may be associated with a higher risk of pancreatitis. Total cholesterol and LDL-C concentration usually increase by not more than 50%, but a significant (30–40%) increase in lipoprotein(a) concentration may also be observed which may increase the risk of pre-eclampsia, premature delivery, or low birth weight [ 370 ].…”

Section: Treatment Of Lipid Disorders In Specific Populationsmentioning

confidence: 99%

“…In this context, the available data from South Africa, where statins were used in pregnant women with homozygous FH, also did not reveal any risks for either the mother or the child [ 373 ]. Recent studies and data also indicated the possibility of using pravastatin in pregnant women during the last trimester of pregnancy to prevent pre-eclampsia [ 370 ]. Unfortunately, the latest results of a randomised study involving 1120 patients did not confirm this relationship; however, once again, the safety of statins in this group of women has been confirmed [ 374 ].…”

Section: Treatment Of Lipid Disorders In Specific Populationsmentioning

confidence: 99%

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PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

et al. 2021

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In Poland there are still nearly 20 million individuals with hypercholesterolaemia, most of them are unaware of their condition; that is also why only ca. 5% of patients with familial hypercholesterolaemia have been diagnosed; that is why other rare cholesterol metabolism disorders are so rarely diagnosed in Poland. Let us hope that these guidelines, being an effect of work of experts representing 6 main scientific societies, as well as the network of PoLA lipid centers being a part of the EAS lipid centers, certification of lipidologists by PoLA, or the growing number of centers for rare diseases, with a network planned by the Ministry of Health, improvements in coordinated care for patients after myocardial infarction (KOS-Zawał), reimbursement of innovative agents, as well as introduction in Poland of an effective primary prevention program, will make improvement in relation to these unmet needs in diagnostics and treatment of lipid disorders possible.

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Section: Treatment Of Lipid Disorders In Specific Populationsmentioning

confidence: 99%

Section: Treatment Of Lipid Disorders In Specific Populationsmentioning

confidence: 99%

PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

et al. 2021

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“…33 A prospective study suggested that blood lipids, especially lipoproteins, are involved in the pathogenesis of preeclampsia. 34 It has been proposed that either excessive inflammation or an imbalance in angiogenic factors causes preeclampsia, and high levels of antiangiogenic factors have been shown to be correlated with an increased incidence of preeclampsia and disease severity. 35 Preeclampsia was associated with the development of metabolic syndrome postpartum in women without prepregnancy metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Association of high maternal triglyceride levels early and late in pregnancy with adverse outcomes: A retrospective cohort study

Xue

Zhou

et al. 2021

Journal of Clinical Lipidology

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BACKGROUND: Excess maternal triglyceride (mTG) exposure during early or late pregnancy increases risks of adverse pregnancy outcomes. However, it is inconclusive whether persistently high maternal triglyceride during whole pregnancy has more negative associations. OBJECTIVE: To explore whether persistently high maternal triglyceride (mTG) levels from early to late pregnancy further increases the risk of adverse pregnancy outcomes. METHODS: We included 12,715 women who had a singleton birth and who underwent routine serum lipid screenings in both early (9-13 weeks) and late (28-42 weeks) pregnancy during May 2018 to July 2019 in a university-based maternity center. Risks for gestational diabetes mellitus (GDM), preeclampsia, preterm delivery, small/large for gestational age (LGA) were estimated. RESULTS: Elevated mTG levels during early pregnancy were associated with increased risks of preterm delivery (AOR, 1.52; 95% CI, 1.21 to 1.90), preeclampsia (1.75; 1.29 to 2.36), gestational diabetes mellitus (1.95; 1.69 to 2.25), and LGA (1.28; 1.12 to 1.46). Compared with those with low mTG levels both in the 1st and 3rd trimesters, persistently high mTG levels increased the risks of preeclampsia (2.53; 1.66 to 3.84), GDM (1.97; 1.57 to 2.47), and LGA (1.68; 1.37 to 2.07). However, persistently high mTG levels only slightly increased risk of LGA when compared with high mTG levels during the 1st trimester alone (1.34, 1.01 to 1.77).

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“…However, the cholesterol levels in advanced biological cells are maintained within a fairly narrow range, and the negative feedback regulation of endogenous cholesterol synthesis plays an important role in maintaining the cholesterol metabolic balance [20, 21]. Moreover, the biological effect of serum cholesterol is associated with low-density lipoprotein (LDL) [22]. It is manifested by the fact that about two-thirds of endogenous cholesterol is transported by LDL [23].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Effect of Preoperative Apolipoprotein B Level in Surgical Patients with Clear Cell Renal Cell Carcinoma

Wang

Chen

et al. 2020

Oncol Res Treat

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Background: The aim of this study was to assess the prognostic value of the preoperative apolipoprotein B (ApoB) level in surgical patients with clear cell renal cell carcinoma (ccRCC). Materials and Methods: The study included 307 ccRCC patients receiving radical or partial nephrectomy between 2003 and 2012 in our center. The correlations among the preoperative ApoB, clinicopathological parameters, and overall survival (OS) were evaluated. Results: A total of 193 males (62.9%) and 114 females (37.1%) with ccRCC who underwent radical or partial nephrectomy were enrolled in the present study. The OS at 5 years after the operation was 90.6% for all patients, 87.4% for the lower ApoB group, and 97.0% for the higher-ApoB group. The cause-specific survival (CSS) at 5 years after surgery was 90.2% for all patients, 86.7% for the lower-ApoB group, and 97.0% for the higher-ApoB group. A higher-ApoB level was related to a better OS and CSS in ccRCC patients (p = 0.001 and p < 0.001, respectively). In multivariate analysis, age > 60 years (p = 0.008 and p = 0.023) and a lower Apo B level (p = 0.019 and p = 0.018) were independent prognostic factors for OS and CSS, respectively. Conclusions: In the Apo apolipoprotein family, the preoperative ApoB level had an important clinical significance for predicting the prognosis and survival rate of ccRCC patients.

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Correlation of elevated levels of lipoprotein(a), high-density lipoprotein and low-density lipoprotein with severity of preeclampsia: a prospective longitudinal study

Cited by 20 publications

References 26 publications

PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

Association of high maternal triglyceride levels early and late in pregnancy with adverse outcomes: A retrospective cohort study

Prognostic Effect of Preoperative Apolipoprotein B Level in Surgical Patients with Clear Cell Renal Cell Carcinoma

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