Correlation of fluorodeoxyglucose uptake and tumor-proliferating antigen Ki-67 in lymphomas

Shou, Yi; Lu, Jianping; Chen, Tao; Ma, Dalie; Tong, Linjun

doi:10.4103/0973-1482.95182

Cited by 17 publications

(10 citation statements)

References 13 publications

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“…It has also been reported that a high SUVmax on PET scans is associated with a shorter survival in patients with DLBCL [26]. Moreover, Shou et al recently reported that lymphomas showing intense FDG uptake have an increased capacity for proliferation and rapid growth, which was confirmed by the Ki-67 expression [27]. In the present study, the bilateral cases had high levels of sIL-2R and a high SUVmax on PET/CT compared with unilateral cases.…”

Section: Discussionmentioning

confidence: 98%

Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis

et al. 2013

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BackgroundPrimary adrenal lymphoma (PAL) is an extremely rare subtype of extranodal non-Hodgkin’s lymphoma. Some researchers have reported some of the characteristics of PAL and its association with poor prognosis; however, the clinicopathological features of PAL remain to be elucidated.MethodsFrom 2008 to 2011 we experienced seven cases of PAL in our institutions. We retrospectively analyzed the clinical and pathological features of these patients.ResultsThe patients ranged in age from 50 to 85 years, with a median of 71 years. The overall male:female ratio was 6:1. All seven patients were diagnosed with diffuse large B-cell lymphoma (DLBCL) pathologically. Bilateral adrenal involvement was confirmed in five patients. The median largest tumor diameter at diagnosis was 58 mm. The Ki-67 index was generally high (>70%). All patients were treated with rituximab-containing chemotherapy, and central nervous system (CNS) prophylaxis was conducted for three patients. One patient with CNS involvement at the time of the diagnosis also received whole-brain radiation. The overall survival rate at two years was 57% (median follow-up; 24.8 months). It is noteworthy that the three patients who received a full course of the rituximab-containing regimen and CNS prophylaxis are currently alive without disease relapse, and that none of the seven patients died due to progression of lymphoma.ConclusionsPrimary adrenal DLBCL can be a clinically aggressive disease entity. Rituximab-containing chemotherapy combined with CNS prophylaxis could be a reasonable option for the treatment of PAL; however, analyses of more PAL cases are needed for the establishment of this strategy.

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Section: Discussionmentioning

confidence: 98%

Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis

et al. 2013

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“…Some researchers believe that the FDG uptake differences may be a reflection of tumor's proliferation [33, 34]. Shou et al [35] investigated the correlation between FDG uptake and tumor-proliferating antigen Ki-67 in lymphomas. Their results suggested that greater proliferative ability was the leading cause for higher FDG uptakes, and tumors of high proliferation such as DLBCL often showed a significantly high FDG uptake; in contrast, FDG uptake was relatively low in tumors of indolent proliferation.…”

Section: Discussionmentioning

confidence: 99%

Ability of ¹⁸F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma

Wang

Zhou

et al. 2019

Contrast Media & Molecular Imaging

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Purpose. To investigate the value of SUV metrics and radiomic features based on the ability of 18F-FDG PET/CT in differentiating between breast lymphoma and breast carcinoma. Methods. A total of 67 breast nodules from 44 patients who underwent 18F-FDG PET/CT pretreatment were retrospectively analyzed. Radiomic parameters and SUV metrics were extracted using the LIFEx package on PET and CT images. All texture parameters were divided into six groups: histogram (HISTO), SHAPE, gray-level co-occurrence matrix (GLCM), gray-level run-length matrix (GLRLM), neighborhood gray-level different matrix (NGLDM), and gray-level zone-length matrix (GLZLM). Receiver operating characteristics (ROC) curves were generated to evaluate the discriminative ability of each parameter, and the optimal parameter in each group was selected to generate a new predictive variable by using binary logistic regression. PET predictive variable, CT predictive variable, the combination of PET and CT predictive variables, and SUVmax were compared in terms of areas under the curve (AUCs), sensitivity, specificity, and accuracy. Results. Except for SUVmin (p=0.971), the averages of FDG uptake metrics of lymphoma were significantly higher than those of carcinoma (p≤0.001), with the following median values: SUVmean, 4.75 versus 2.38 g/ml (P<0.001); SUVstd, 2.04 versus 0.88 g/ml (P=0.001); SUVmax, 10.69 versus 4.76 g/ml (P=0.001); SUVpeak, 9.15 versus 2.78 g/ml (P<0.001); TLG, 42.24 versus 9.90 (P<0.001). In the ROC curves analysis based on radiomic features and SUVmax, the AUC for SUVmax was 0.747, for CT texture parameters was 0.729, for PET texture parameters was 0.751, and for the combination of CT and PET texture parameters was 0.771. Conclusion. The SUV metrics in 18FDG PET/CT images showed a potential ability in the differentiation between breast lymphoma and carcinoma. The combination of SUVmax and PET/CT texture analysis may be promising to provide an effectively discriminant modality for the differential diagnosis of breast lymphoma and carcinoma, even for the differentiation of subtypes of lymphoma.

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“…[7] On histopathological examination of the lesion, the Ki-67 index was below 10%. In this case, both the bone scintigraphy and gallium scan were positive whereas the FDG-PET scan was negative.…”

Section: Discussionmentioning

confidence: 99%

False negative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography in primary b-cell lymphoma of the bone

et al. 2017

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We present a case of a 15-year-old male with primary bone lymphoma who was initially referred for suspicion of chronic osteomyelitis of the mandible. A bone scan and gallium scan demonstrated congruent uptake in the mandible, suggestive of chronic osteomyelitis. A biopsy subsequently showed B-cell lymphoma of the bone with low Ki-67. A fluorodeoxyglucose positron emission tomography (FDG-PET) scan performed before therapy for staging revealed no increased uptake in the mandible. This case shows an atypical presentation of a rare disorder and is presented to emphasize the importance of baseline FDG-PET.

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Correlation of fluorodeoxyglucose uptake and tumor-proliferating antigen Ki-67 in lymphomas

Abstract: Ki-67 staining, a reflection of tumor-proliferation activity, was significantly related to the FDG uptake value in lymphoma lesions.

Cited by 17 publications

References 13 publications

Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis

Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis

Ability of ¹⁸F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma

False negative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography in primary b-cell lymphoma of the bone

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Correlation of fluorodeoxyglucose uptake and tumor-proliferating antigen Ki-67 in lymphomas

Abstract: Ki-67 staining, a reflection of tumor-proliferation activity, was significantly related to the FDG uptake value in lymphoma lesions.

Cited by 17 publications

References 13 publications

Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis

Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis

Ability of 18F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma

False negative 18F-fluorodeoxyglucose positron emission tomography/computed tomography in primary b-cell lymphoma of the bone

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Ability of ¹⁸F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma

False negative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography in primary b-cell lymphoma of the bone