Correlation of Foveal Avascular Zone Size With Foveal Morphology in Normal Eyes Using Optical Coherence Tomography Angiography

Samara, Wasim A.; Say, Emil Anthony T.; Khoo, Chloe T.L.; Higgins, Timothy Patrick; Magrath, George N.; Ferenczy, S; Shields, Carol L.

doi:10.1097/iae.0000000000000847

Cited by 327 publications

(296 citation statements)

References 33 publications

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“…On the other hand, vascular disruption in eyes suffering from DR can be so pronounced that in two eyes deep FAZ was not completely contained in the 3 3 3-mm scan. This could be explained considering that FAZ is usually larger at deep capillary plexus, and, as already mentioned, deep vascular layer disruption is more pronounced in DR. 17,28 With regard to vessel density, our study showed a poor interchangeability across different angiocubes for every plexus and every subgroup. Several aspects should be considered to interpret this finding.…”

Section: Discussionmentioning

confidence: 71%

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Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

Rabiolo

Gelormini

Marchese

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the macular quantitative parameters interchangeability of three different optical coherence tomography angiography (OCT-A) angiocubes (i.e., 3 3 3, 6 3 6, and 12 3 12 mm) on healthy subjects and patients affected by diabetic retinopathy (DR) and to assess the interrater reliability of such indices across the different scan protocols. METHODS.Retrospective study involving 20 eyes of healthy subjects and 20 eyes with DR. All eyes underwent swept-source OCT-A with 3 3 3-, 6 3 6-, and 12 3 12-mm angiocubes centered on the fovea. Foveal avascular zone (FAZ) area and vessel density on 3 3 3-, 6 3 6-, and 12 3 12-mm macular scans were calculated by three independent operators at all retina, superficial, deep, and choriocapillary vascular layers. Interchangeability and interrater reliabilities were estimated using intraclass correlation coefficient (ICC).RESULTS. Interscan reproducibility of FAZ area was very strong (ICC > 0.85) at every plexus. On the contrary, vessel density values significantly varied across different scan sizes (ICC < 0.51). Intrascan interrater reliability was high for all retina and superficial FAZ areas, while it was satisfactory at deep capillary plexus only for 3 3 3-mm scan.CONCLUSIONS. FAZ area at all plexuses is a robust parameter even if calculated on angiocubes with different size. However, interrater reliability is higher when measured in smaller scans. Conversely, vessel density results depend on the size of angiocube, although their interrater reliability is extremely high. Studies involving OCT-A should take into consideration that scan size may influence macular perfusion parameters and interrater reliability.

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Section: Discussionmentioning

confidence: 71%

“…The FAZ area was manually measured at all retina, superficial, and deep vascular layers using a previously published method. 16,17 Briefly, the FAZ area was encircled using the polygon selection tool and its area was recorded in squared millimeters.…”

Section: Quantitative Analysis Of Oct-a Imagesmentioning

confidence: 99%

Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

Rabiolo

Gelormini

Marchese

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…15,50,51 Studies assessing FAZ measurement using OCTA technology have recently been published. 12,13,24,31,45,46,52,53 These studies reported the FAZ area of normal eyes to be 0.250 to 0.474 mm 2 , depending on the characteristics of the study participants, type of OCTA machine, segmentation, and image analysis method. In patients with glaucoma, the FAZ area is reported to be enlarged compared with that in normal controls, which ranged from 0.360 to 0.435 mm 2 .…”

Section: Discussionmentioning

confidence: 99%

An Optical Coherence Tomography Angiography Study of the Relationship Between Foveal Avascular Zone Size and Retinal Vessel Density

Kwon

Choi²,

Shin

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To assess the relationship between the size of the foveal avascular zone (FAZ; area and perimeter) and vessel density (VD) at various retinal regions using optical coherence tomography angiography (OCTA) in patients with open-angle glaucoma (OAG).METHODS. In this retrospective cross-sectional study, OAG eyes were grouped according to the presence/absence of central visual field (CVF) defects. A control group of normal eyes was also included. OCTA images were obtained from the optic nerve (4.5 3 4.5 mm 2 ) and macular (3 3 3 mm 2 ) area, in which VDs were measured in the circumpapilla, parafovea, and fovea regions. Partial correlation analyses between FAZ parameters representing size and VDs at different retinal regions were performed. The correlation between FAZ parameters and macular ganglion cell-inner plexiform layer thickness (mGCIPLT) and CVF mean sensitivity (MS) was also assessed. For spatial correspondence, correlations between FAZ parameters and corresponding VD, mGCIPLT, and CVF-MS measurements were assessed at each hemiretina. RESULTS.A total of 126 OAG eyes and 40 controls were reviewed. Overall, FAZ parameters showed statistically significant correlations with VDs measured at the fovea, parafovea, and circumpapilla (FAZ area: r ¼ À0.603, À0.385, À0.256; P < 0.001, < 0.001, and 0.003, respectively). These correlations were observed regardless of the presence of CVF defects (all P < 0.05). FAZ size showed significant spatial correlations with VD, mGCIPLT, and CVF-MS measurements at each hemiretina.CONCLUSIONS. OCTA-derived FAZ area and perimeter showed statistically significant correlations with VDs measured at various retinal locations with spatial correspondence in OAG.

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“…The measurement of FAZ area and the evaluation of FAZ integrity are very important because the enlargement of FAZ precedes the occurrence of microaneurisms and the diabetic retinopathy in this stage can be reversed [24,25]. Ischemic maculopathy is an ophthalmoscopically occult maculopathy if there is no associated with cotton wool spots.…”

Section: Editorialmentioning

confidence: 99%

Ischemic Maculopathy: Anoccult Cause of an Irreversible Visual Loss

Turgut¹

2017

AOVS

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Correlation of Foveal Avascular Zone Size With Foveal Morphology in Normal Eyes Using Optical Coherence Tomography Angiography

Cited by 327 publications

References 33 publications

Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

An Optical Coherence Tomography Angiography Study of the Relationship Between Foveal Avascular Zone Size and Retinal Vessel Density

Ischemic Maculopathy: Anoccult Cause of an Irreversible Visual Loss

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