Correlation of Glycated Hemoglobin and Iron Deficiency Anemia among Diabetic and Non Diabetic Patients

Veeramalla, Vydehi; Madas, Swetha

doi:10.20546/ijcmas.2017.612.308

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…Some authors focused on studying HbA1c levels and anemias, such as iron deficiency anemia (IDA) [29]: a chronic disorder attributed to a reduction in the production of red blood cells that may cause an increase in HbA1c [30]. A significant improvement in the levels of HbA1c was reported in various studies after treatment with iron supplements [31,32]. The association between the HbA1c levels and IDA has been established and shows that there are factors other than glucose that can affect HbA1c, and this should be taken into consideration [32].…”

Section: Discussionmentioning

confidence: 99%

“…A significant improvement in the levels of HbA1c was reported in various studies after treatment with iron supplements [31,32]. The association between the HbA1c levels and IDA has been established and shows that there are factors other than glucose that can affect HbA1c, and this should be taken into consideration [32]. Finally, the outcomes are conflicting regarding the link between iron and diabetes [24].…”

Section: Discussionmentioning

confidence: 99%

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Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia

et al. 2021

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The homeostasis of trace elements were observed to contribute to certain diabetic outcomes. This cross-sectional study determined the differences and associations between serum levels of copper (Cu), iron (Fe) and zinc (Zn) in Saudi patients with and without type 2 diabetes mellitus (T2DM) as well as those with prediabetes. Anthropometrics were measured, and fasting blood samples were collected from 119 patients with T2DM (aged 41–64 years), 95 non-T2DM (aged 27–55 years) and 80 with prediabetes (aged 35–57 years). Circulating trace minerals were determined using an inductively coupled plasma–mass spectrometer. Serum levels of Cu and Fe were significantly lower in T2DM than non-T2DM (adjusted p-values < 0.001). There was no difference in the Zn levels of the T2DM and non-T2DM groups. The serum Cu levels were significantly lower in the prediabetes group than the non-T2DM group (p < 0.05). The serum levels of Cu, Fe and Zn were inversely associated with circulating glucose in the T2DM and prediabetes subjects (p-values < 0.001). In conclusion, the differences in circulating trace elements were observed in Saudi subjects with varying glycemic statuses, suggesting an inverse association between T2DM progression and the decreasing serum Cu, Fe and Zn levels. Intervention trials are warranted to determine whether early correction of trace mineral deficiencies is beneficial in populations at higher risk for T2DM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia

et al. 2021

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“…Glycated Hb also known as HbA1c , is used as a guideline to check the status of patients glycemic status for preceding 3 months or it represents value for glucose preceding 8 to 12 weeks and provides criteria for assessing glucose control, Glycated Hb values are free of day to day glucose fluctuations and unaffected by recent exercise or food ingestion. 6,7 HbA1c of 6.5% is recommended as the cut point for the diagnosis of diabetes. 8 Human Adult Hb consists of HbA (97% of the total, it is made up of 4 polypeptide chains, 2α and 2β), HbA 2 ( 2.5% , made up of 2α and 2δ) and HbF (0.5%, and made up of 2α and 2γ).…”

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confidence: 99%

Glycated Haemoglobin- Recent Developments and Review on Non-Glycemic Variables

Lata Kanyal Butola,

Ranjit Ambad,

Deepika Kanyal

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Glycated hemoglobin (HbA1c) is the current tool for monitoring glycemic control once a diagnosis of diabetes is established. Its role in the diagnosis of diabetes has only recently come to attention. In the past, many international organizations have discussed the role of HbA1c in the diagnosis of diabetes and rejected this application as appropriately DCCT-aligned assays were not used or available globally. Considering the high biological variability, the dynamics of glucose, as well as the limitations of blood glucose monitoring technology, at that time, the possibility of obtaining an integrated average glycemia value by the measurement of a single biomarker elicited immense interest and provided a powerful tool in both diabetes research and clinical management. HbA1c testing was soon facilitated by the development of a new analytical methodology that was suitable for use in clinical laboratories. However, a consensus statement in 2007 on assays used to report HbA1c has now further strengthened the case for a change in the diagnosis of diabetes. Using HbA1c as a screening or diagnostic tool has some logistical advantages over traditional glucose testing (either oral glucose tolerance test [OGTT] or fasting plasma glucose [FPG]). Patients can present for a relatively quick test in a non-fasted state at any point of the day, allowing more scope for opportunistic screening. HbA1c assay readings are less prone to recent influences of physical or emotional stress and provide an indication of longer term glycemic control spanning the last 2-3 months. Owing to such logistical advantages there are calls for HbA1c to become the preferred diagnostic tool over glucose tests. Performing the HbA1c test regularly allows the assessment of glycemic control and verification of the efficacy of medication treatment and of education for self-care. It is estimated that 33% to 49% of people with DM2 cannot achieve adequate goals for glucose, blood pressure, or lipid profile control and only 14% reach normal parameters in these measurements.

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Monitoring and management of hyperglycemia in patients with advanced diabetic kidney disease

Escott

Silveira

Cancelier

et al. 2021

Journal of Diabetes and its Complications

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Correlation of Glycated Hemoglobin and Iron Deficiency Anemia among Diabetic and Non Diabetic Patients

Cited by 5 publications

References 14 publications

Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia

Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia

Glycated Haemoglobin- Recent Developments and Review on Non-Glycemic Variables

Monitoring and management of hyperglycemia in patients with advanced diabetic kidney disease

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