Correlation of Heterozygote risk, Pathological risk and lifetime risk with Clinicopathologic Features in Iranian breast cancer patients

Abstract

Breast cancer is a common malignancy comprising 24.4% of all cancers and is the leading cause of death among Iranian women (1, 2). Approximately 5-10% of all breast cancers are attributable to the strong hereditary susceptibility, highly penetrant genes, such as BRCA1/2 (3).Women carrying germ line mutations in these genes have an extremely high lifetime risk of developing breast and/or ovarian cancer (4). Among Carriers of BRCA1/2 mutations, the Lifetime risk of breast cancer is 56% to 84% by age 70 (4-7). Estimation the mutation probability is important for various Breast cancer is a prevalent malignancy among women worldwide and a principle reason of death in Iranian women. In current study, 64 Iranian women diagnosed with breast cancer and classified into four age groups (<35 years, 35-49 years, 50-64 years and >65 years) were analyzed for correlation between heterozygote risk and lifetime risk with clinicopathological features. Nine patients were also investigated for BRCA1 germline mutations. Our results indicated that people with hetrozygosity risk over 30% more likely to infect invasive ductal carcinoma and utilization of Cyrillic software for Iranian family would open new sights towards the prediction, prognosis and mutation detection. Keywords