Correlation of Histopathological Study of Breast Lesions with cytology and mammography as a measure of internal quality and diagnostic accuracy

Abstract

Background: Breast cancer is the one of the leading causes death in women. Triple test approach has been widely accepted in asymptomatic women for the preoperative diagnosis of the breast lesions. Triple test includes clinical examination, mammography and Fine Needle Aspiration Cytology (FNAC) to differentiate between neoplastic and non-neoplastic lesions, histopathological confirmation being the gold standard for neoplasticlesions and best management plan for the patient.The aim was to study the histopathological spectrum of breast lesions and correlate the cytological and radiological findings with histopathological examination and to determine sensitivity, specificity and diagnostic accuracy of FNACand mammography in the diagnosis of the breast lesions. Methods:The study comprised of 552 casesofhistopathologically diagnosed breast lesions over the period of twelve years in a rural tertiary health care centre catering rural population. Results:Of the 552 cases examinedhistopathologically, 375 cases (67.9%) were benign lesions, 177 cases (32.1%) were malignant. Fibroadenoma was the commonest benign lesion, whereas infiltrating ductal carcinoma was the commonest malignant tumour. Incidence of phyllodes tumour was significantly higher compared to other studies. Overall sensitivity, specificity and diagnostic accuracy of FNAC and mammography were 95.9%, 98%, 96.6% and 84.7%, 78.5%,81.1% respectively. Conclusion:Histopathology plays an important role in diagnostic and therapeutic management of neoplastic breast lesionswith preoperative Triple test being an important supportive investigation in rapid diagnosis withfairly good sensitivity,specificity and diagnostic accuracyin neoplastic lesions. Significantly higher incidence of phyllodes tumor needs further investigation for causative mechanism.

Retrospective Analysis of Mammogram, Sonomammogram and Its Histopathological Correlation as an Aid for Diagnosis of Breast Lesions

“…The association was much clear in false positives involving a cytology examination or biopsy, and in women with a family history of breast cancer. [14] Mulka A et al (2017) concluded that Mammography can diagnose more malignant lesions than benign because mammography was done after 35 years of age. It showed that majority of non-neoplastic cases are reported in the third decade.…”

Radiological and cytological correlation of breast lesions with histopathology: A study in a tertiary care centre

“…Breast malignancies are most often encountered and the second most common malignancy in Indian women. The incidence rate of breast malignancies in India is around 85 per 10,000 women per year [3,4] . Benign breast diseases because of their high incidence and cancerous potential of some of the histological subtypes deserve attention [5] .…”