Correlation of HOMA-IR with BMI-for-age percentile in children and adolescents from the Soconusco region of Chiapas, Mexico

Abstract

Introduction: Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases. In pediatrics, morbidity and mortality associated with these diseases highlights the diagnostic importance of IR for primary care.Objective: To determine Homeostatic Model Assessment Insulin Resistance (HOMA-IR) values and their correlation with BMI-for-age percentile in children and adolescents of the Soconusco region of Chiapas, Mexico.Materials and methods: Cross-sectional study. Overweight and obesity prevalence was determined based on the Body Mass Index (BMI) percentile of 112 children (5-19 years old). Glucose and fasting insulin values were quantified and used for estimation of HOMA-IR.Results: The combined prevalence of obesity and overweight was 66%, with insulin (p=0.010) and HOMA-IR (p=0.015) values higher than those of the normal weight group. The HOMA-IR values correlated positively with age (r=0.636), weight (r=0.569), height (r=0.578) and BMI percentile (r=0.198).Conclusions: In the study population, HOMA-IR has a moderately significant correlation with an increase in BMI percentile.

Rate of Weight Gain and its Association with Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) among Obese Children attending Paediatric Endocrine Clinic, Hospital Universiti Sains Malaysia

“…The findings are also reported in other studies in which there was a significant correlation of increase BMI with HOMA- IR; and a longitudinal reduction of BMI cause decline in HOMA-IR. 7 These studies are consistent with our study in which there was a significant correlation between weight gain with HOMA-IR at 6 months follow up (r=0.737; p <0.001). The time to gain 5 kg from the baseline was 1.6 times increased in the presence of insulin resistance at 6 months follow up in patients with obesity.…”

“…According to a study by Chang-Rueda et al, among children and adolescents, HOMA-IR had a moderately significant correlation with an increase in BMI percentile for age (r=0.198, p= 0.037). 7 The result showed that the combined prevalence of obesity and overweight was 66% with insulin ( p= 0.010) and HOMA-IR ( p= 0.015) values higher than those in the normal weight group. The HOMA-IR values correlated positively with age (r=0.636), weight (r=0.569), height (r=0.578) and BMI percentile (r=0.198).…”

Predictability of HOMA-IR for Gestational Diabetes Mellitus in Early Pregnancy Based on Different First Trimester BMI Values

“…Several surrogate estimates have been proposed for assessing insulin sensitivity, including HOMA-IR, HOMA-β, and QUICKI [ 20 , 21 ]. However, the threshold of HOMA-IR for evaluating insulin resistance has not been unified because of various associated factors of HOMA-IR, including age, sex, race, and weight [ 22 , 23 , 24 ]. HOMA-IR is strongly correlated with body weight as there is a significant difference in HOMA-IR between normal weight and obese individuals [ 25 ].…”