Correlation of human papilloma virus status with quantitative perfusion/diffusion/metabolic imaging parameters in the oral cavity and oropharyngeal squamous cell carcinoma: comparison of primary tumour sites and metastatic lymph nodes

Han, Miran; Lee, S.J.; Lee, D.; Kim, S.Y.; Choi, Jin Wook

doi:10.1016/j.crad.2018.04.005

Cited by 20 publications

(46 citation statements)

References 33 publications

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“…However, the MTV of LNs was found to be higher in the HPV-positive group than in the HPV-negative one. Our results on DCE-MRI are in line with previous investigations that did not report any difference in perfusion parameters according to HPV status, for both PTs and metastatic LNs [22,28]. While conflicting results have been reported on the association between 18 F-FDG-PET/CT parameters and HPV-status, some studies documenting SUV values of PTs have shown that these are lower in HPV-positive than in HPV-negative patients [38][39][40].…”

Section: Plos Onesupporting

confidence: 92%

“…Previous studies have focused on the correlation between perfusion and metabolic imaging in HNSCC, using DCE-MRI and 18 F-FDG PET or 18 F-FMISO (fluoromisonidazole) PET [19][20][21][22][23][24][25][26][27][28], as well as with simultaneous PET/MR systems [21,23,32,36]. However, most of these studies investigated perfusion and metabolic parameters in the PT [19][20][21]23,24,26], while only a few investigations have evaluated the metastatic LNs [25,27,28], reporting conflicting results.…”

Section: Plos Onementioning

confidence: 99%

“…Several investigations have already focused on the relationships between DCE-MRI and 18 F-FDG-PET/computed tomography (CT) parameters, even though these results are conflicting in HN tumors [19][20][21][22][23][24][25]. Most of the previous studies on DCE-MRI and/ or PET/CT have only evaluated primary tumors [19][20][21]23,24,26], while only a small number of investigations also included the metastatic lymph nodes (LNs) [25,[27][28]. Furthermore, limited research has addressed vascular heterogeneity within the lesion, using a histogrambased approach instead of the mean values of parameters, to better reveal the relationships between perfusion and metabolic variables [19,22].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

et al. 2020

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Objectives To investigate the correlation between histogram-based Dynamic Contrast-Enhanced magnetic resonance imaging (DCE-MRI) parameters and positron emission tomography with 18 F-fluorodeoxyglucose (18 F-FDG-PET) values in oropharyngeal squamous cell carcinoma (OPSCC), both in primary tumors (PTs) and in metastatic lymph nodes (LNs). Methods 52 patients with a new pathologically-confirmed OPSCC were included in the present retrospective cohort study. Imaging including DCE-MRI and 18 F-FDG PET/CT scans were acquired in all patients. Both PTs and the largest LN, if present, were volumetrically contoured. Quantitative parameters, including the transfer constants, K trans and K ep , and the volume of extravascular extracellular space, v e , were calculated from DCE-MRI. The percentiles (P), P10, P25, P50, P75, P90, and skewness, kurtosis and entropy were obtained from the histogram-based analysis of each perfusion parameter. Standardized uptake values (SUV), SUV max , SUV peak , SUV mean , metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated applying a SUV threshold of 40%. The correlations between all variables were investigated with the Spearman-rank correlation test. To exclude false positive results under multiple testing, the Benjamini-Hockberg procedure was applied.

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Section: Plos Onesupporting

confidence: 92%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

et al. 2020

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“…In the present study, differences between SUVmax or SUVmean and HPV or p16 presence were insignificant. Comparable results have been obtained in other studies, where no differences in SUVmax values between p16-and HPV-positive, and p16-and HPV-negative patients were reported [40][41][42]. By contrast, Schouten et al demonstrated that SUVmax in HPV-positive tumors was significantly lower than in HPV-negative tumors [43].…”

Section: Discussionsupporting

confidence: 51%

Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients

Samołyk-Kogaczewska¹,

Sierko

Dziemiańczyk-Pakieła

et al. 2020

Cancers

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(1) Background: The novel hybrid of positron emission tomography/magnetic resonance (PET/MR) examination has been introduced to clinical practice. The aim of our study was to evaluate PET/MR usefulness in preoperative staging of head and neck cancer (HNC) patients (pts); (2) Methods: Thirty eight pts underwent both computed tomography (CT) and PET/MR examination, of whom 21 pts underwent surgical treatment as first-line therapy and were further included in the present study. Postsurgical tissue material was subjected to routine histopathological (HP) examination with additional evaluation of p16, human papillomavirus (HPV), Epstein-Barr virus (EBV) and Ki67 status. Agreement of clinical and pathological T staging, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of CT and PET/MR in metastatic lymph nodes detection were defined. The verification of dependences between standardized uptake value (SUV value), tumor geometrical parameters, number of metastatic lymph nodes in PET/MR and CT, biochemical parameters, Ki67 index, p16, HPV and EBV status was made with statistical analysis of obtained results; (3) Results: PET/MR is characterized by better agreement in T staging, higher specificity, sensitivity, PPV and NPV of lymph nodes evaluation than CT imaging. Significant correlations were observed between SUVmax and maximal tumor diameter from PET/MR, between SUVmean and CT tumor volume, PET/MR tumor volume, maximal tumor diameter assessed in PET/MR. Other correlations were weak and insignificant; (4) Conclusions: Hybrid PET/MR imaging is useful in preoperative staging of HNC. Further studies are needed.

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“…HPV-positive oropharyngeal cancers generally have more favorable prognosis than HPV-negative SCC [3]. There are certain imaging findings that may be helpful for differentiating HPV-positive SCC from the HPV-negative counterparts [4, 5]. In particular, HPV-positive SCC tend to display well-defined borders and cystic nodal metastases, while the HPV-negative tumors more commonly have poorly defined borders (Fig.…”

Section: Oral Cavity and Oropharynx Tumorsmentioning

confidence: 99%

Updated WHO nomenclature of head and neck lesions and associated imaging findings

2019

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This article reviews the imaging features of head and neck lesions with updated 2017 World Health Organization (WHO) nomenclature. The major WHO changes include refined terminology of existing entities, descriptions of new tumor types, elimination of defunct categories, and updated biological characterization of various tumor types. In particular, the updates pertaining to the following conditions will be reviewed: tumors of the oral cavity and oropharynx, including HPV-positive or HPV-negative squamous cell carcinoma, small cell carcinoma; tumors of the hypopharynx, larynx, trachea, and parapharyngeal space, including nomenclature revisions for laryngeal neuroendocrine tumors; tumors of the nasal cavity and paranasal sinuses including newly added entities such as NUT carcinoma and biphenotypic sinonasal sarcoma; odontogenic and maxillofacial bone tumors, including the reversal of terminology for certain cystic lesions; tumors of the salivary glands, including updated terminology related to high-grade transformation and polymorphous adenocarcinomas tumors; temporal bone lesions including modifications of the nomenclature and classification criteria; tumor-like lesions of the neck and lymph nodes, with a discussion encompassing developmental cysts, metastases of unknown primary, and heterotopia-associated neoplasia; and mucosal melanoma. Familiarity with the proper WHO terminology for conditions that might be mentioned in differential diagnoses and a general understanding of the behavior of head and neck lesions can help optimize imaging assessment and reporting.

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Correlation of human papilloma virus status with quantitative perfusion/diffusion/metabolic imaging parameters in the oral cavity and oropharyngeal squamous cell carcinoma: comparison of primary tumour sites and metastatic lymph nodes

Cited by 20 publications

References 33 publications

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients

Updated WHO nomenclature of head and neck lesions and associated imaging findings

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