Correlation of human papillomavirus 16 and 18 with cervical cancer and their diagnosis methods in Iranian women: A systematic review and meta-analysis

Fani, Mona; Mahmoodi, Pegah; Emadzadeh, Maryam; Avan, Amir; Karimi, Ehsan; Ferns, Gordon A.; Amiri, Iraj Sadegh

doi:10.1016/j.currproblcancer.2019.06.008

Cited by 15 publications

(9 citation statements)

References 23 publications

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“…HPV 16 and HPV 18 are the most prevalent HPV genotypes in women with normal Pap smear and cancerous samples [ 20 , 21 ]. Although the burden of HPV 16 and HPV 18 has reduced following vaccination, their potential contribution to cancer progression remains unchanged.…”

Section: Discussionmentioning

confidence: 99%

“…According to different studies in Iran, it seems that the abundance of HPV 16 is higher than other types of HPV among Iranian women with either normal Pap smear or cancerous samples; however, HPV 18, as the second most dominant genotype in cervical cancer, may not be observed frequently in normal samples [ 1 , 20 ]. Since both viruses have different variants, many studies have shown that some HPV 16 variants, especially non-A variants, play a critical role in the development of an invasive form of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

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Genetic Diversity of HPV 16 and HPV 18 Based on Partial Long Control Region in Iranian Women

Kesheh

Barazandeh

Kaffashi

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Human papillomavirus (HPV) 16 and HPV 18 account for 75% of all cervical cancers. The L1 gene, encoding the major surface protein (MSP), is used to classify HPV types (lineages and sublineages), genotypes, and intratypic variants. Therefore, this study aimed to investigate the lineages, sublineages, genetic variabilities, and mutation effects on transcription factor binding sites by using partial sequences of the HPV 16 and HPV 18 long control regions (LCRs) in these samples. Materials and Methods. After DNA isolation from 56 positive samples, the LCR of HPV 16 and HPV 18 were amplified using specific primers, and phylogenetic trees were drawn through MEGA X. Compared to the reference sequences, single nucleotide polymorphisms (SNPs) were identified. The transcription binding sites were also evaluated using the online PROMO database. Results. The LCRs of 52 samples were successfully sequenced. Overall, 81.58% of all HPV 16 variants belonged to the D1 sublineage, followed by A4 (13.16%), A1 (2.63%), and C1 (2.63%) sublineages. All HPV 18 isolates belonged to A sublineage, 92.85% to A3 sublineage, and 7.15% to A4 sublineage. Out of 27 SNPs in the HPV 16 LCR, A7382T, T7384G, C7387T, C7393G, A7431G, T7448C, and C7783A were HPV 16-specific. Also, among 14 SNPs in the HPV 18 LCR, C7577A and A7943T were not previously reported. An insertion (C) between 7432 and 7433 positions was identified in all studied HPV 16 variants. Besides, most of the HPV 16 mutations were embedded in the YY1, TFIID, Oct-2, and NF-1 binding sites, while c-Fos and MBF1, as the most common binding sites, were affected by HPV 18 LCR mutations. Conclusion. The present results showed that D1 and A3 were the dominant sublineages of HPV 16 and HPV 18, respectively. Therefore, women infected with these variants need to be examined in further longitudinal studies to obtain more information about the oncogenic potential of these dominant variants in Iran. Besides, YY1, TFIID, Oct-2, NF-1, c-Fos, and MBF1 were the most frequent binding sites, which were influenced by the mutations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic Diversity of HPV 16 and HPV 18 Based on Partial Long Control Region in Iranian Women

Kesheh

Barazandeh

Kaffashi

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“… 3 More than 90 genotypes of HPV have been identified and classified either as low-risk (LR) types (predominantly HPV6 and HPV11) causing genital warts. High-risk (HR) HPV types (predominantly HPV16 and HPV18) cause cancer of the cervix, 4 its pathogenic role has also been demonstrated by others with oropharyngeal cancers. 5 6 Persistent infection with HPV16 is the major cause of anal cancer.…”

Section: Introductionmentioning

confidence: 94%

Anal human papillomavirus infection among men who have sex with men and transgender women living with and without HIV in Pakistan: findings from a cross-sectional study

et al. 2021

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ObjectivesThe aim of this study was to determine the prevalence of infection, genotypes and risk factors for human papillomavirus (HPV) among men who have sex with men (MSM) and transgender women living with and without HIV in Pakistan. Anal infection with HPV is very common worldwide among MSM, particularly among MSM living with HIV. The high prevalence of HIV among MSM and male-to-female transgendered individuals in Pakistan is a significant health concern since access to screening and health-seeking is often delayed in this stigmatised key population.DesignThis cross-sectional study was conducted between March 2016 and November 2017.Participants, setting and data collectionThis study recruited MSM and transgender-women who self-reported to have had anal sex in the last 6 months, and were at least 18 years of age, from the sexual health and antiretroviral therapy centres. Structured questionnaires were administered, and blood samples were obtained to confirm HIV status. Anal swabs were collected for HPV-DNA detection and typing.Main outcome measuresThe primary outcome was the prevalence of ‘HPV-DNA infection’. The prevalence ratios (PR) were calculated using Cox proportional hazard model algorithms to analyse the association between exposure variables and HPV-infection.ResultsComplete data were available for 298 MSM and transgender women (HIV +n=131; HIV−n=167). The overall HPV-DNA prevalence was 65.1% and was higher in participants living with HIV as compared with HIV-negative (87% vs 48%; χ2p≤0.001). Likewise, 28.9% of participants living with HIV were infected with two or more than two types of HPV as compared with 18.8% participants without HIV(χ2 p≤0.001). The most frequent HPV type was HPV6/11 (46.9%), followed by HPV16 (35.1%), HPV18 (23.2%) and HPV35 (21.1%). HIV status (PR 2.81, 95% CI 2.16 to 3.82) and never condom use (PR 3.08, 95% CI 1.69 to 5.60)) were independently associated with prevalence of ‘anal-HPV16 infection’ when adjusting for confounding for age, other sexual and behavioural factors, for example, smoking and alcohol consumption.ConclusionHigh prevalence of HPV indicates a substantial future risk of anal cancer in Pakistani MSM and transgender women, and particularly in those living with HIV. Current findings support anal Pap-smear HPV screening for this particular group and vaccination efforts for future generations.

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“…HPV types 16 and 18 were found in 22% of HPV-positive cases in Tampere, Finland (3). Among HPV-positive cervical cancers in Iranian women, 48.5% were HPV16 and 12.5% were HPV18 positive (4). HPV16 and HPV18 are highly prevalent in cervical cancer, and belong to a subset of high-risk HPVs.…”

Section: Introductionmentioning

confidence: 96%

Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes

Sun

Xie

et al. 2020

Int J Mol Med

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Resveratrol is a representative polyphenol of diet-derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resveratrol has been shown to induce the apoptosis, and reduce both the viability and mitotic index of a number of cancer cell lines, including human cervical cancer cells. In the present study, it was confirmed that resveratrol inhibited the HPV E6 mRNA, HPV E6 protein and phosphorylated retinoblastoma protein (p-pRb1) levels, and increased the p53 protein levels in HeLa and Ca Ski cells, as well as in subcutaneous tumor tissue grown from HeLa cells. High-risk HPV uses a bicistronic RNA to control E6 and E7 genes simultaneously. On the whole, the present study demonstrates that resveratrol inhibits cervical cancer development by suppressing the transcription and translation of E6 and E7, and also by promoting the apoptosis and G1/S phase transition arrest. These findings may provide the basis for the development of resveratrol as a candidate for cervical cancer therapy.

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Correlation of human papillomavirus 16 and 18 with cervical cancer and their diagnosis methods in Iranian women: A systematic review and meta-analysis

Cited by 15 publications

References 23 publications

Genetic Diversity of HPV 16 and HPV 18 Based on Partial Long Control Region in Iranian Women

Genetic Diversity of HPV 16 and HPV 18 Based on Partial Long Control Region in Iranian Women

Anal human papillomavirus infection among men who have sex with men and transgender women living with and without HIV in Pakistan: findings from a cross-sectional study

Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes

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