Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Rubie, Claudia; Frick, Vilma Oliveira; Pfeil, Sandra; Wagner, Mathias; Kollmar, Otto; Kopp, Berit; Gräber, Stefan; Rau, Bettina; Schilling, Martin K.

doi:10.3748/wjg.v13.i37.4996

Cited by 107 publications

(83 citation statements)

References 40 publications

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“…These results are in agreement with previous data showing down-regulation of these cytokines in rats fed with phytosteryl ferulates, a possible precursor of HCAF [43]. IL-8 is up-regulated in patients with ulcerative colitis [44] and has been correlated with colorectal carcinogenesis [45]. In our experiments IL-8 was decreased by HCAF treatment almost to control levels.…”

Section: Discussionsupporting

confidence: 83%

Polyphenol metabolites from colonic microbiota exert anti‐inflammatory activity on different inflammation models

Larrosa

Luceri

Vivoli

et al. 2009

Molecular Nutrition Food Res

230

191

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The polyphenols in fruits and vegetables may be partly responsible for the health-promoting effects attributed to fruit and vegetable intake. Although their properties have been relatively well studied, the activity of their metabolites, produced after ingestion, has been poorly investigated. Thus, the aim of this work was to study the potential anti-inflammatory effect of 18 polyphenol metabolites, derived from colon microbiota. They were screened by measuring prostaglandin E(2) (PGE(2)) production by CCD-18 colon fibroblast cells stimulated with IL-1beta. Metabolites that inhibited more than 50% PGE(2) production were hydrocaffeic (HCAF), dihydroxyphenyl acetic (dOHPA), and hydroferulic acid (HFER), that subsequently were tested with the writhing and paw pressure test in rodents where all three compounds showed an anti-inflammatory effect. The effect of HCAF administered orally (50 mg/kg) was also tested in the dextran sodium sulfate (DSS)-induced colitis model. Weight loss and fecal water content were more pronounced in DSS rats than in DSS-HCAF treated rats. HCAF treatment diminished the expression of the cytokines IL-1beta, IL-8, and TNF-alpha, reduced malonyldialdehyde (MDA) levels and oxidative DNA damage (measured as 8-oxo-2'-deoxyguanosine levels) in distal colon mucosa. These results indicate that HCAF, dOHPA, and HFER have anti-inflammatory activity in vitro and in vivo.

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Section: Discussionsupporting

confidence: 83%

Polyphenol metabolites from colonic microbiota exert anti‐inflammatory activity on different inflammation models

Larrosa

Luceri

Vivoli

et al. 2009

Molecular Nutrition Food Res

230

191

View full text Add to dashboard Cite

show abstract

“…IL8 is also closely related with cancer (Lokshin et al, 2006). The study by Rubie et al suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases (Rubie et al, 2007). In accordance with previous findings, IL8-related domain was significantly enriched in present study.…”

Section: Discussionsupporting

confidence: 82%

Analysis of Key Genes and Pathways Associated with Colorectal Cancer with Microarray Technology

Liu¹,

Shu²,

Hou³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: Microarray data were analyzed to explore key genes and their functions in progression of colorectal cancer (CRC). Methods: Two microarray data sets were downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified using corresponding packages of R. Functional enrichment analysis was performed with DAVID tools to uncover their biological functions. Results: 631 and 590 DEGs were obtained from the two data sets, respectively. A total of 32 common DEGs were then screened out with the rank product method. The significantly enriched GO terms included inflammatory response, response to wounding and response to drugs. Two interleukin-related domains were revealed in the domain analysis. KEGG pathway enrichment analysis showed that the PPAR signaling pathway and the renin-angiotensin system were enriched in the DEGs. Conclusions: Our study to systemically characterize gene expression changes in CRC with microarray technology revealed changes in a range of key genes, pathways and function modules. Their utility in diagnosis and treatment now require exploration.

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“…the expression of il-8 in tumor tissue significantly correlated with tumor size, depth of infiltration and liver metastasis, and tumor stage. 26,27 ueda et al 28 reported that serum il-6 levels correlated closely with serum il-8 and ca 19-9 levels. our results show a similar correlation between il-6 and il-8 serum levels but did not find a correlation with ca 19-9. similar to il-8, Vegf is also a pleiotropic cytokine triggering inflammatory, immunoresponse, and cancerogenic effects.…”

Section: Screening Performance Of Biomarkers Il-8 Vegf Ca 19-9 Andmentioning

confidence: 99%

Toward Standardized High-Throughput Serum Diagnostics: Multiplex–Protein Array Identifies IL-8 and VEGF as Serum Markers for Colon Cancer

Bünger

Haug

Kelly³

et al. 2011

SLAS Discovery

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Development and progression of colon cancer may be related to cytokines. Cytokines with diagnostic value have been identified individually but have not been implemented into clinical praxis. Using a multiplex protein array, the authors explore a panel of cytokines simultaneously and compared its performance to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). Serum concentrations of 12 cytokines were simultaneously determined by multiplex biochip technology in 50 colon cancer patients and 50 healthy controls. Serum levels of interleukin-8 (IL-8) and CEA were significantly higher in cancer patients than in healthy controls. Areas under the receiver operating characteristic curves (AUCs) were largest for IL-8, followed by CEA, vascular endothelial growth factor (VEGF), and CA 19-9. Analyses regarding marker combinations showed an advantage over single marker performance for CEA, VEGF, and CA 19-9 but not for IL-8. Multiplex biochip array technology represents a practical tool in cytokine and cancer research when simultaneous determination of different biomarkers is of interest. The results suggest that the assessment of IL-8, CEA, VEGF, and possibly CA 19-9 serum levels could be useful for colon cancer screening with the potential of also detecting early stage tumors. Further validation studies using these and additional markers on a multiplex array format are encouraged.

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Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Cited by 107 publications

References 40 publications

Polyphenol metabolites from colonic microbiota exert anti‐inflammatory activity on different inflammation models

Polyphenol metabolites from colonic microbiota exert anti‐inflammatory activity on different inflammation models

Analysis of Key Genes and Pathways Associated with Colorectal Cancer with Microarray Technology

Toward Standardized High-Throughput Serum Diagnostics: Multiplex–Protein Array Identifies IL-8 and VEGF as Serum Markers for Colon Cancer

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