Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with ASC-US/hrHPV+: a retrospective analysis of 2292 cases

Liu, Qin; Zhang, Tao; Chen, Liqing; Zhou, Xin; Zhang, Xiaofei; Zheng, Wenxin; Niu, Shuang; Zhou, Feng

doi:10.1136/jcp-2022-208580

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Our previous study showed that in the NILM/hrHPV‐positive population, the older patient group exhibited a lower risk of cervical precancer but a higher risk of cancer 21 . Similarly, in ASC‐US/hrHPV‐positive women, the prevalence of cervical SCC is significantly higher in older women than in younger women 22 . In the current study, 25–39 age years group showed a significantly higher prevalence of CIN1 ( p = .032).…”

Section: Discussionsupporting

confidence: 52%

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Correlation of immediate prevalence of cervical squamous cell precancers and cancers with HPV genotype and age in women with LSIL cytology: A retrospective analysis of 1617 cases

Chen,

Zhu,

Chen

et al. 2023

Diagnostic Cytopathology

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AimsTo evaluate the immediate risk of cervical squamous cell precancers and cancers in women with low‐grade squamous intraepithelial lesion (LSIL) cytology according to different high‐risk human papillomavirus (hrHPV) results and age stratification.MethodsThe study included 1617 women with LSIL cytology and underwent simultaneous Aptima HPV genotyping (E6/E7 mRNA test) followed by cervical biopsy.ResultsAmong 1317 hrHPV positive cases, other 11 types of hrHPV were the most frequent (68.8%), followed by HPV16 (11.1%), HPV18/45 (4.1%), and HPV16/HPV18/45 (0.5%). Compared to other groups, HPV18/45 positive group and other 11 types of hrHPV group showed significantly higher prevalence of intraepithelial neoplasia grade (CIN)1 (p < .0001), while HPV16 positive and HPV16/HPV18/45 dual positive groups showed significantly higher prevalence of CIN2/3 (p < .0001). In addition, hrHPV positive, 25–39 years‐old age group showed a significantly higher prevalence of CIN1 (p = .032) than the other age groups. Furthermore, CIN1 prevalence was significantly higher in patients under 40 or 50 years of age than in those over 40 or 50 years of age (p = .005 and p = .011, respectively). However, there was no significant difference among the different age groups in CIN2/3 prevalence in women with LSIL cytology.ConclusionIn southern Chinese women population, LSIL cytology carries very low immediate risk of high‐grade squamous intraepithelial lesions (HSIL) (CIN2/3) in general. However, HPV16 positive and HPV16/HPV18/45 dual positive indicated a higher immediate risk of high‐grade squamous intraepithelial lesions (HSIL) (CIN2/3). Age is not an immediate risk factor in this patient population for high‐grade squamous lesions or SCC. These results are similar to data from cytology laboratories in the United States and other international settings, therefore strongly support the usage of ASCCP guidelines in this patient population.

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Section: Discussionsupporting

confidence: 52%

“…21 Similarly, in ASC-US/hrHPV-positive women, the prevalence of cervical SCC is significantly higher in older women than in younger women. 22 In the current study, 25-39 age years group showed a significantly higher prevalence of CIN1 ( p = .032). However, similar to the findings in a study by Rodríguez,23 This study has some limitations.…”

Section: Discussionsupporting

confidence: 45%

Correlation of immediate prevalence of cervical squamous cell precancers and cancers with HPV genotype and age in women with LSIL cytology: A retrospective analysis of 1617 cases

Chen,

Zhu,

Chen

et al. 2023

Diagnostic Cytopathology

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“…"Because the rate of pre-neoplastic disease is low (8), few studies of women over age 30 have the power to further stratify by age in order to better inform guidelines" (7)(8)(9)(10)(11) Women with all grades of "pathology-confirmed cervical intraepithelial neoplastic (CIN)" showed a reduction in HR-HPV identification with age, with the most pronounced decline seen for HPV 16 infection, according to a recent study from the ATHENA trial, that contained data on more than thirty five thousand women aged thirty and older. "In the HPV in Perimenopause (HIP) cohort of routinely screened women age 35-60 years, we observed a similar trend of decreasing correlation between HR-HPV detection and cervical abnormalities with increasing age" Our goal was to learn more about the relationship between agerelated aberrant cytology and either HPV and HR-HPV detection (12)(13)(14).…”

Section: Introductionmentioning

confidence: 85%

relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women

Javed,

Nadeem,

Arif

et al. 2023

ijhs

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Background: In this research, premenopausal women with HR-HPV infections and atypical cervical smears were compared by age. Materials and method: 200 regularly screened women between the ages of 36 and 60 had a cervical smear and HPV detection. Demographic, behavioral, and medical data were gathered by telephone surveys. Descriptive analysis was used to look at the connection between HR-HPV infections and cervical aberrations by age. Results: Age significantly decreased the number of cases of cervical abnormalities, HR-HPV, and human papillomavirus, as well as the correlation among these disorders. In younger females with abnormalities, HR-HPV detection was 60%; however, it steadily decreased to 30% in "50-54-year-old" women, without abnormalities found in 55-60 years old females. Different relationships between HR-HPV infection and anomalies remained found in females over 45, a pattern not observed in females who were young by age. Conclusion: Age had no effect on several kinds of low-grade and severe anomalies, but we saw a decline in the agreement among cytological results and HR-HPV tests.

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“…However, different genotypes of hrHPV carry different risks of developing high-grade lesions 15 . In our previous studies, we demonstrated the benefit of risk-stratifying patients with NILM and ASC-US cytology based on hrHPV genotype for optimizing patient management 16 , 17 . However, there is limited research on the association between ASC-H/HSIL cytology and hrHPV infection using Aptima assays, particularly on a large scale in China.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of cervical precancers or cancers in women with ASC-H/HSIL cytology according to Aptima HPV (AHPV) assay-detected HPV genotypes and age

Liu,

Chen,

et al. 2024

J. Cancer

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Objective : Aimed to potentially risk-stratify patients with different cervical cytology diagnoses, by HPV genotypes and/or age, we have conducted a series of studies to examine the prevalence of cervical precancers and cancers for women with different cytology diagnoses. This paper will be focusing on patients with ASC-H/HSIL cytology. Methods : In total, 1183 patients aged 20-78 years with atypical squamous cells, cannot rule out HSIL (ASC-H)/HSIL by cytology underwent AHPV assay and cervical biopsy in a developed region in southern China were included in this study. Results : Overall, 59.2% women with ASC-H/HSIL cytology had cervical intraepithelial neoplasia (CIN)2/3 lesions while 1.6% had adenocarcinoma in situ (AIS) lesions. Compared to other groups, HPV-16+ group (80.8%) showed a significantly higher prevalence of CIN2/3 than other genotype+ groups (p<0.0001). Further, HPV-16+ (9.3%) or HPV-18/45+ (6.3%) group showed a significantly higher prevalence of squamous cell carcinoma (SCC) than other genotype+ groups (p<0.0001). The prevalence of AIS glandular lesions in HPV-18/45+ group (13.8%) is significantly higher than other genotype groups (p<0.0001). When stratified by age, younger group showed a significantly higher prevalence of CIN2/3 (p=0.009) while older group presented an obvious higher prevalence of SCC (p<0.0001). Conclusions : In this patient population, among women with ASC-H/HSIL cytology, HPV positive groups are at significantly higher risk of CIN2/3 compared to HPV negative group. Specifically, prevalence of CIN2/3 and SCC is significantly higher in HPV-16+ group while AIS lesions are more prevalent among HPV-18/45+ patients. In addition, younger group showed a significantly higher prevalence of CIN2/3 while older group presented an obvious higher prevalence of SCC.

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Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with ASC-US/hrHPV+: a retrospective analysis of 2292 cases

Cited by 3 publications

References 32 publications

Correlation of immediate prevalence of cervical squamous cell precancers and cancers with HPV genotype and age in women with LSIL cytology: A retrospective analysis of 1617 cases

Correlation of immediate prevalence of cervical squamous cell precancers and cancers with HPV genotype and age in women with LSIL cytology: A retrospective analysis of 1617 cases

relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women

Prevalence of cervical precancers or cancers in women with ASC-H/HSIL cytology according to Aptima HPV (AHPV) assay-detected HPV genotypes and age

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