Correlation of immunoglobulin and C reactive protein levels in ankylosing spondylitis and rheumatoid arthritis.

Sanders, Karen M.; Hertzman, Alex; Escobar, Mario R.; Littman, Bruce H.

doi:10.1136/ard.46.4.273

Cited by 19 publications

(6 citation statements)

References 20 publications

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“…To determine whether the maternal immune system was more active in subjects with higher IgM antibody levels, we assessed the relationship between IgM levels and C‐reactive protein, an acute‐phase reactant that is part of the innate immune response (CRP; see S.I.). While we did not find a significant association, previous studies suggest that CRP levels may not correlate with all antibodies (Nguyen et al, ; Sanders et al, ) and can vary across different types of infections or autoimmune disorders (Durán et al, ). Fourth, unknown genetic or environmental factors not measured in our study may contribute to the T. gondii IgM association with childhood autism.…”

Section: Discussioncontrasting

confidence: 95%

Prenatal toxoplasmosis antibody and childhood autism

et al. 2016

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There is evidence that some maternal infections during the prenatal period are associated with neurodevelopmental disorders, such as childhood autism. However, the association between autism and Toxoplasma gondii (T. gondii), an intracellular parasite, remains unclear. The authors examined whether serologically confirmed maternal antibodies to T. gondii are associated with odds of childhood autism in offspring. The study is based on a nested case-control design of a large national birth cohort (N = 1.2 million) and the national psychiatric registries in Finland. There were 874 cases of childhood autism and controls matched 1:1 on date of birth, sex, birthplace and residence in Finland. Maternal sera were prospectively assayed from a national biobank for T. gondii IgM and IgG antibodies; IgG avidity analyses were also performed. High maternal T. gondii IgM antibody was associated with a significantly decreased odds of childhood autism. Low maternal T. gondii IgG antibody was associated with increased offspring odds of autism. In women with high T. gondii IgM antibodies, the IgG avidity was high for both cases and controls, with the exception of three controls. The findings suggest that the relationship between maternal T. gondii antibodies and odds of childhood autism may be related to the immune response to this pathogen or the overall activation of the immune system. Autism Res 2017, 10: 769-777. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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Section: Discussioncontrasting

confidence: 95%

Prenatal toxoplasmosis antibody and childhood autism

et al. 2016

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“…The correlation among serum levels of total IgA with C-reactive protein (CRP), clinical signs, and the activity of the disease in patients with AS was observed by other researchers in the 1980s ( 36 – 40 ). However, other authors did not find a positive correlation between IgA and CRP ( 41 ). Finally, in 1996, Wendling and collaborators evaluated the serum levels of SIgA, total IgA, and free SC in patients with AS and found higher levels compared to healthy controls, regardless of HLA-B27 status and peripheral or axial involvement ( 42 ).…”

Section: Introductionmentioning

confidence: 94%

Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis

et al. 2017

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IntroductionBoth reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood.ObjectiveTo evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects.MethodsThis was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student’s t-test, Kruskal–Wallis test, and U Mann–Whitney test, with a multivariate evaluation by principal components analysis (PCA). A correlation analysis was carried out using the Pearson correlation coefficient and a linear regression models. All analysis were made using Stata version 11.2® for Windows, R V3.3.21. Statistical significance was defined a p-value <0.05.ResultsIn all, 46 patients (78.2% men; mean age, 34.8 ± 12.3 years) and 53 controls (41% men; mean age, 32 ± 11.4 years) were included in the study. The mean serum levels of SIgA were higher in SpA patients than in healthy subjects (p < 0.001). Only SIgA levels correlated with disease activity: BASDAI (r = −0.42, p = 0.0046), ASDAS-CRP (r = −0.37, p = 0.014), and ASDAS-ESR (r = −0.45, p = 0.0021). The negative correlation between SIgA and all activity indices was higher in HLA-B27-positive patients (BASDAI r = −0.70, p = 0.0009, ASDAS-CRP r = −0.58, p = 0.0093, and ASDAS-ESR r = −0.57, p = 0.0083). The PCA showed three factors: the first component was constituted by variables referred as clinical activity measures, the second did include the serological activity markers, and the last component was compounded by age and symptoms time.ConclusionElevated serum levels of SIgA were found to be related with low disease activity in patients with ReA and uSpA.

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“…These have shown the possibility that, as in meningitic CSF, CRP is either selectively bound in synovium or specifically consumed in a synovial fluid, which may play a role in rheumatoid inflammation (49,50). Serum CRP has been shown to correlate significantly with radiographic changes in rheumatoid arthritis (51); it also has a significant positive correlation with rheumatoid arthritic disease as a whole (49)(50)(51)(52).…”

Section: Serial Measurementsmentioning

confidence: 99%