Correlation of intrahepatic pressure with collagen in the Disse space and hepatomegaly in humans and in the rat

Histological-hemodynamic correlation in cirrhosis—a histological classification of the severity of cirrhosis

“…Several, mostly pathophysiological, studies have correlated histopathologic features on liver biopsy with the degree of portal hypertension in patients with liver disease. In patients with alcoholic liver disease, a positive correlation has been identified between intrahepatic pressure and both hepatocyte size and collagen in the space of Disse [13], parameters that are not routinely assessed. Other studies have shown progressive increases in HVPG with increasing severity of liver disease (normal, chronic hepatitis, pre-cirrhosis and cirrhosis) both in alcoholic [14] and in non-alcoholic liver disease [15] that in turn is associated with greater periportal and lobular abnormalities [16].…”

Silent non-alcoholic fatty liver disease—a clinical–histological study

“…In many circumstance (autoimmune, acute, alcoholic and drug-induced-hepatitis) ballooning degeneration is of secure pathologic significance in the presentation and progression of liver disease. The liver cell enlargement may progress through ballooning degeneration to necrosis or apoptosis [29,30]; furthermore, some experimental studies report a strong positive correlation between hepatocyte enlargement, intra-hepatic pressure and collagen in the Disse-space [31][32][33]. It is true that glycogen accumulation in the nuclei may be conspicuous in certain adult pathologic conditions such as diabetes [34], obesity [34] chronic heart failure, and Wilson's disease; yet this feature is frequent in childhood and, in our knowledge, there is not any evidence that it may be deleterious.…”

Assessment of Liver Function and Liver Fibrosis with Dynamic Gd-EOB-DTPA–Enhanced MRI

“…Although the arterial fraction of liver perfusion is increased in patients with cirrhosis (17), portal perfusion is crucial for the peak contrast-enhanced MR signal. Portal perfusion is markedly reduced in severe liver fibrosis (18), prolonging T in . Moreover, the increase in vascular resistance prolongs the time required by blood flow to complete its route from the sinusoids to the hepatic vein.…”