Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Güreşçi, Servet; Özmen, Özlem; Uzman, Metin; Şimşek, Gülçin Güler; Tatci, Ebru; Yeniova, Abdullah Özgür

doi:10.3906/sag-1410-24

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…High Ki67 proliferation index was found to predict the recurrence of DTC and shortened disease-free survival in certain studies (22). Previous studies revealed a positive correlation between Ki-67 proliferation index, focal 18F-FDG uptake, and SUVmax values in certain types of cancer, and the proliferative activity was linked to the metabolic activity of tumor (23)(24)(25). To the best of our knowledge, the relationship between Ki67 labeling index and 18F-FDG uptake in thyroid nodules has not been studied yet.…”

Section: Discussionmentioning

confidence: 94%

Relation of 18F-FDG PET/CT Positivity with Tumor Cytopathology, Galectin-3, PTEN, Ki-67 and NIS Expressions in Thyroid Nodules

Çakmak¹,

Aydoğan²,

Ersöz³

et al. 2018

Turk J Endocrinol Metab

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The expressions of certain molecular markers have been found to be related with 18F-FDG uptake in differentiated thyroid cancer. The goal of this study was to assess the relationship between NIS, galectin-3, PTEN, Ki-67 expressions and 18F-FDG positron emission tomography positivity in thyroid nodules. Material and Methods: Fifteen patients with 27 nodules who had incidental focal 18F-FDG uptake in thyroid and underwent total thyroidectomy were included. Immunohistochemical staining with galectin-3, NIS, PTEN, and Ki-67 were performed. Results: Among the 27 nodules, 19 nodules were diagnosed as papillary thyroid carcinoma. Malignant-positron emission tomography positive (n=13), malignant-positron emission tomography negative (n=6) and benign-positron emission tomography positive nodules (n=8) were classified as group A, B, and C, respectively. PTEN loss was frequent in the malignant nodules compared to the benign ones [19 (42.1%) vs. 1 (12.5%), p=0.01]. NIS positive staining was significantly frequent in older patients (p=0.019). Mean Ki-67 proliferation index, galectin-3, PTEN and NIS expressions were not different between the three groups. SUV max values were not statistically different between the malignant and benign nodules with focal 18F-FDG uptake (7.7±5.4 vs. 7.0 ±4.4, p=0.8). Conclusion: The FDG-positron emission tomography/computed tomography positivity was not associated with Galectin-3, NIS, Ki-67 and PTEN expressions. SUV max values were not different in the malignant and benign nodules but the PTEN loss was frequent in malignant nodules. We suggest that the role of molecular markers in the development of differentiated thyroid cancer with 18F-FDG uptake should be investigated in further studies with a larger patient group.

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Section: Discussionmentioning

confidence: 94%

Relation of 18F-FDG PET/CT Positivity with Tumor Cytopathology, Galectin-3, PTEN, Ki-67 and NIS Expressions in Thyroid Nodules

Çakmak¹,

Aydoğan²,

Ersöz³

et al. 2018

Turk J Endocrinol Metab

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“…The 18 F-FDG PET/CT protocol and interpretation were described in a previous study ( 23 ). All patients underwent whole-body FDG PET using a GE Discovery 710 PET/CT scanner (General Electric Medical Systems, GEMS, USA).…”

Section: Methodsmentioning

confidence: 99%

Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of 18F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer

et al. 2021

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BackgroundThe role of 18F-flurodeoxyglucose (18F-FDG) positron emission tomography–computed tomography (PET/CT) in colorectal cancer (CRC) remains unclear. This study aimed to explore the association of the maximum standardized uptake value (SUVmax), a parameter of 18F-FDG PET/CT, with KRAS mutation, the Ki-67 index, and survival in patients with CRC.MethodsData of 66 patients with CRC who underwent 18F-FDG PET/CT was retrospectively collected in our center. The clinical significance of the SUVmax in CRC and the association of the SUVmax with KRAS mutation and the Ki-67 index were determined. A meta-analysis was conducted by a systematic search of PubMed, Web of Science, and CNKI databases, and the data from published articles were combined with that of our study. The association of the SUVmax with KRAS mutation and the Ki-67 index was determined using the odds ratio to estimate the pooled results. The hazard ratio was used to quantitatively evaluate the prognosis of the SUVmax in CRC.ResultsBy analyzing the data of 66 patients with CRC, the SUVmax was found not to be related to the tumor-node-metastasis stage, clinical stage, sex, and KRAS mutation but was related to the tumor location and nerve invasion. The SUVmax had no significant correlation with the tumor biomarkers and the Ki-67 index. Data of 17 studies indicated that the SUVmax was significantly increased in the mutated type compared with the wild type of KRAS in CRC; four studies showed that there was no remarkable difference between patients with a high and low Ki-67 index score regarding the SUVmax. Twelve studies revealed that the SUVmax had no significant association with overall survival and disease-free survival in CRC patients.ConclusionsBased on the combined data, this study demonstrated that the SUVmax of 18F-FDG PET/CT was different between colon and rectal cancers and associated with KRAS mutation but not the Ki-67 index; there was no significant association between the SUVmax and survival of patients with CRC.

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“…Güreşci et al reported a significant correlation of Ki-67 index with SUV max of FDG uptake in colorectal lesions including CRC and colon adenoma [13]. Moreover, higher proliferation is related to poorer outcomes in CRC [14].…”

Section: Figure 2 Pathological Features Of Colorectal Cancer and Adenoma (A)mentioning

confidence: 99%

Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma

Minamimoto

Endo

2021

Diagnostics

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An age of 70-year-old man was incidentally found two focal high 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) uptake in the descending colon and in the sigmoid colon. We observed the feature of these two areas in the preplanned 4′-[methyl-11C]-thiothymidine (4DST) positron emission tomography (PET)/computed Tomography (CT)providing cell proliferation imaging. A mass forming high 4DST uptake in the descending colon and focal moderate 4DST uptake in the sigmoid colon was confirmed, and that were proven pathologically as adenocarcinoma and moderate to severe type tubular adenoma, respectively. This is the first report to present that colorectal adenoma can be visualized by proliferation PET imaging and the degree of uptake may enable discrimination of colorectal adenoma from adenocarcinoma, based on pathological considerations.

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Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Cited by 3 publications

References 17 publications

Relation of 18F-FDG PET/CT Positivity with Tumor Cytopathology, Galectin-3, PTEN, Ki-67 and NIS Expressions in Thyroid Nodules

Relation of 18F-FDG PET/CT Positivity with Tumor Cytopathology, Galectin-3, PTEN, Ki-67 and NIS Expressions in Thyroid Nodules

Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of 18F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer

Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma

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