Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock

Wang, Biao; Chen, Gang; Cao, Yuelong; Xue, Jiping; Li, Jia; Wu, Yunfu

doi:10.1016/j.jcrc.2014.10.030

Cited by 83 publications

(101 citation statements)

References 25 publications

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“…It is found that as there is gradually increase in serum lactate albumin ra o there is corresponding increase in mortality. Our study findings were similar with study done by B wang et al which found that mortality in pa ents with severe sepsis and sep c shock correlates with increased lactate/albumin 23 ra o. Similar finding were also found in study done by 29 Seung J et al…”

Section: Discussionsupporting

confidence: 93%

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Serum Lactate Albumin Ratio as a Predictor of Mortality in Severe Sepsis and Septic Shock at Tribhuwan University Teaching Hospital, Kathmandu

Thapa

Prasad

Shakya

2017

Birat J. Health Sci.

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IntroductionSevere sepsis and septic shock, is a common cause of emergency room admission and is associated with high morbidity and mortality worldwide. This study inspects the prediction of mortality in severe sepsis and septic shock with increased lactate/albumin ratio.Objective The objective of the study was to predict the serum lactate albumin ratio as an indicator of mortality in severe sepsis and septic shock.MethodologyIt was a hospital based cross sectional study done at Tribhuvan University Teaching Hospital, Kathmandu from November 2015 to October 2016. The consent was taken from patients. Acute Physiology and Chronic Health Evaluation II score, serum lactate and serum albumin levels on first day of arrival in emergency room were calculated. Patients were classified as severe sepsis and septic shock and treated according to Surviving Sepsis Campaign 2012 guideline. The patient were follow up at 28 day, The associations of 28-day outcome with Acute Physiology and Chronic Health Evaluation II score, serum lactate value, serum albumin value and serum lactate albumin ratio value were derived.ResultsOut of total 240 severe sepsis and septic shock patients it is found that increased serum lactate/albumin ratio was an independent predictor of the mortality with cut off value of 0.07. Furthermore serum lactate albumin ratio shows strong correlation with APACHE 2 score in predicting mortality in severe sepsis and septic shock.ConclusionIncreased lactate/albumin ratio predicts mortality in patients with severe sepsis and septic shock. Birat Journal of Health Sciences Vol.2/No.1/Issue 2/ Jan - April 2017, Page: 191-195

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Section: Discussionsupporting

confidence: 93%

“…Thus, rather than an analysis serum lactate and serum albumin, we used serum lactate /albumin ra o as a prognos c index. The combina on of these two markers merged inflammatory and nutri onal factors, both 23 of which predicts prognosis.…”

Section: Discussionmentioning

confidence: 99%

Serum Lactate Albumin Ratio as a Predictor of Mortality in Severe Sepsis and Septic Shock at Tribhuwan University Teaching Hospital, Kathmandu

Thapa

Prasad

Shakya

2017

Birat J. Health Sci.

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“…It was shown that a BNP decline over time implied a favorable outcome and lower mortality risk. [30] High levels of D-dimer, [31] total bilirubin, [32] and low levels of albumin [33] were shown to be associated with mortality sepsis patients.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a mortality risk model for pediatric sepsis

Chen

et al. 2017

Medicine

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Pediatric sepsis is a burdensome public health problem. Assessing the mortality risk of pediatric sepsis patients, offering effective treatment guidance, and improving prognosis to reduce mortality rates, are crucial.We extracted data derived from electronic medical records of pediatric sepsis patients that were collected during the first 24 hours after admission to the pediatric intensive care unit (PICU) of the Hunan Children's hospital from January 2012 to June 2014. A total of 788 children were randomly divided into a training (592, 75%) and validation group (196, 25%). The risk factors for mortality among these patients were identified by conducting multivariate logistic regression in the training group. Based on the established logistic regression equation, the logit probabilities for all patients (in both groups) were calculated to verify the model's internal and external validities.According to the training group, 6 variables (brain natriuretic peptide, albumin, total bilirubin, D-dimer, lactate levels, and mechanical ventilation in 24 hours) were included in the final logistic regression model. The areas under the curves of the model were 0.854 (0.826, 0.881) and 0.844 (0.816, 0.873) in the training and validation groups, respectively.The Mortality Risk Model for Pediatric Sepsis we established in this study showed acceptable accuracy to predict the mortality risk in pediatric sepsis patients.

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“…To expedite the initiation of effective treatments and thereby reduce mortality and associated costs, better methods to identify patients with severe sepsis are needed Hemodynamic parameters and laboratory tests, including lactate levels are currently used to predict multiple organ failure (MOF) in patients with sepsis; however information regarding how to detect early organ failure is limited [2, 3]. Clinical deterioration and death result from a complex interaction between inflammation and coagulation that leads to organ dysfunction [4].…”

Section: Introductionmentioning

confidence: 99%

Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis

et al. 2016

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Objective To determine if serum levels of endothelial adhesion molecules were associated with the development of multiple organ failure (MOF) and in-hospital mortality in adult patients with severe sepsis. Design This study was a secondary data analysis of a prospective cohort study. Setting Patients were admitted to two tertiary intensive care units in San Antonio, TX, between 2007 and 2012. Patients Patients with severe sepsis at the time of intensive care unit (ICU) admission were enrolled. Inclusion criteria were consistent with previously published criteria for severe sepsis or septic shock in adults. Exclusion criteria included immunosuppressive medications or conditions. Interventions None. Measurements Baseline serum levels of the following endothelial cell adhesion molecules were measured within the first 72 hours of ICU admission: Intracellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Vascular Endothelial Growth Factor (VEGF). The primary and secondary outcomes were development of MOF (≥2 organ dysfunction) and in-hospital mortality, respectively. Main results Forty-eight patients were enrolled in this study, of which 29 (60%) developed MOF. Patients that developed MOF had higher levels of VCAM-1 (p=0.01) and ICAM-1 (p=0.01), but not VEGF (p=0.70) compared with patients without MOF (single organ failure only). The area under the curve (AUC) to predict MOF according to VCAM-1, ICAM-1 and VEGF was 0.71, 0.73, and 0.54, respectively. Only increased VCAM-1 levels were associated with in-hospital mortality (p=0.03). These associations were maintained even after adjusting for APACHE and SOFA scores using logistic regression. Conclusions High levels of serum ICAM-1 was associated with the development of MOF. High levels of VCAM-1 was associated with both MOF and in-hospital mortality.

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Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock

Cited by 83 publications

References 25 publications

Serum Lactate Albumin Ratio as a Predictor of Mortality in Severe Sepsis and Septic Shock at Tribhuwan University Teaching Hospital, Kathmandu

Serum Lactate Albumin Ratio as a Predictor of Mortality in Severe Sepsis and Septic Shock at Tribhuwan University Teaching Hospital, Kathmandu

Development and validation of a mortality risk model for pediatric sepsis

Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis

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