Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia

Bhati, Balgopal Singh; Nooren, Mirza; Choudhary, Piyush

doi:10.4103/aihb.aihb_46_20

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(2020). [ 21 ] HELLP, psychosis, and jaundice were the added maternal complications seen by Mehta et al . [ 11 ]…”

Section: Discussionmentioning

confidence: 99%

A Study on Serum Lactate Dehydrogenase and Uric Acid in Preeclampsia and Eclampsia: Can they Predict Adverse Fetomaternal Outcome?

Moharana,

Mishra,

Nayak

2023

International Journal of Applied &Amp; Basic Medical Research

View full text Add to dashboard Cite

Background: Hypertensive disorders of pregnancy affect 3%–5% of all pregnancies, contributing immensely to maternal morbidity and mortality. According to the WHO, the incidence of deaths due to preeclampsia and eclampsia in developing and developed countries is 2.8% and 0.4%, respectively. Lactate dehydrogenase (LDH) and uric acid are good predictors of disease severity. Aim: This study aims to determine the fetomaternal outcome in relation to abnormal serum levels of LDH and uric acid. Materials and Methods: A cross-sectional study was carried out in 1200 patients with preeclampsia and eclampsia at a tertiary care center over 2 years. Patients were divided into – Group A: patients with normal LDH (≤300 IU/L) and uric acid (<6 mg/dl) (n = 300). Group B: patients with abnormal LDH and uric acid (n = 900), who were further divided into mild and severe preeclampsia and eclampsia. Abnormal serum values were stratified into groups for easier comparison. The results were compared in terms of maternal and perinatal outcomes. Results: The incidence of preeclampsia and eclampsia in our study is 3.14% and 1.57%, respectively. Significant changes in LDH and uric acid were associated with increased severity of the disease (LDH – 1116.94 ± 4.78; uric acid – 9.2 ± 2.89). Higher incidence of maternal and fetal complications was seen with severe preeclampsia and eclampsia with LDH >800 IU/L and uric acid >6 mg/dl. Conclusion: Standard antenatal follow-up should be carried out for early detection and prevention of preeclampsia, with strict monitoring of serum uric acid level and LDH. This may reduce the maternal and fetal complications due to preeclampsia.

show abstract

“…(2020). [ 21 ] HELLP, psychosis, and jaundice were the added maternal complications seen by Mehta et al . [ 11 ]…”

Section: Discussionmentioning

confidence: 99%

A Study on Serum Lactate Dehydrogenase and Uric Acid in Preeclampsia and Eclampsia: Can they Predict Adverse Fetomaternal Outcome?

Moharana,

Mishra,

Nayak

2023

International Journal of Applied &Amp; Basic Medical Research

View full text Add to dashboard Cite

show abstract

“…Research findings indicate distinct alterations in LDH isoenzymes in severe preeclampsia, with LDH 2 showing a decrease, LDH 3 demonstrating elevation, and LDH 5 exhibiting significant increases in serum and placental extracts in severe cases [ 10 ]. Furthermore, LDH levels have shown a significant correlation with the severity of preeclampsia, with higher levels associated with a greater incidence of maternal and fetal complications [ 6 , 11 , 12 ]. Notably, LDH levels exceeding 800 IU/L were observed in 26% of patients with severe preeclampsia, compared to 11.5% of those with mild preeclampsia, representing a statistically significant difference [ 10 ].…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review on Serum Lactate Dehydrogenase (LDH) and Uric Acid in Preeclampsia: Implications for Maternal Health and Disease Severity

Deeksha,

Pajai,

Reddy Eleti

et al. 2024

Cureus

View full text Add to dashboard Cite

Preeclampsia, a hypertensive disorder unique to pregnancy, remains a significant cause of maternal and fetal morbidity and mortality worldwide. Serum lactate dehydrogenase (LDH) and uric acid have garnered attention as potential biomarkers in understanding preeclampsia's pathophysiology and clinical management. Elevated LDH and uric acid levels have been associated with disease severity and adverse outcomes, highlighting their potential utility in risk stratification and guiding management strategies. This comprehensive review explores the roles of LDH and uric acid in preeclampsia, summarizing current evidence regarding their diagnostic, prognostic, and therapeutic implications. Future research directions are also discussed, including understanding and validation studies. Integrating LDH and uric acid measurements into routine clinical practice may facilitate early detection and intervention, ultimately improving outcomes for preeclamptic pregnancies. This review underscores the importance of serum biomarkers in enhancing our understanding and managing preeclampsia, aiming to optimize maternal and fetal health.

show abstract

Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia

Cited by 2 publications

References 8 publications

A Study on Serum Lactate Dehydrogenase and Uric Acid in Preeclampsia and Eclampsia: Can they Predict Adverse Fetomaternal Outcome?

A Study on Serum Lactate Dehydrogenase and Uric Acid in Preeclampsia and Eclampsia: Can they Predict Adverse Fetomaternal Outcome?

A Comprehensive Review on Serum Lactate Dehydrogenase (LDH) and Uric Acid in Preeclampsia: Implications for Maternal Health and Disease Severity

Contact Info

Product

Resources

About