Correlation of left atrial appendage histopathology, cardiac rhythm and response to maze procedure in patients undergoing surgery for rheumatic valvular heart disease

Singh, A; Desai, B; Hirakannawar, A; Kumar, T. Santosh; Ali, Mohammed; Patwardhan, Anil; Khandeparkar, J.M.S.; Nb, Agarwal; Jd, Khandekar; Vs, Lad

doi:10.1007/s12055-004-0396-x

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“…Prior studies have not addressed the degree of histopathological abnormalities be- tween left and right atrium, their distribution within each atrium, or their differences in the presence or absence of AF. [5][6][7][8][9] We report a prospective histopathological study of biopsies obtained during surgery from multiple sites from both atria in patients with isolated rheumatic MS to compare the differences between patients in SR and AF.…”

Section: Introductionmentioning

confidence: 99%

“…Major barriers to effective therapy for AF in patients with CRVD is a lack of detailed understanding of the histopathological changes in patients in sinus rhythm (SR) and AF, and hence uncertainty on potential therapeutic targets. Prior studies have not addressed the degree of histopathological abnormalities between left and right atrium, their distribution within each atrium, or their differences in the presence or absence of AF . We report a prospective histopathological study of biopsies obtained during surgery from multiple sites from both atria in patients with isolated rheumatic MS to compare the differences between patients in SR and AF.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological Study of Left and Right Atria in Isolated Rheumatic Mitral Stenosis With and Without Atrial Fibrillation

Shenthar

Kalpana

Prabhu

et al. 2016

Cardiovasc electrophysiol

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In rheumatic MS, SR is associated with myocyte hypertrophy whereas AF is associated with myocytolysis. Endocardial inflammation is more common in left atrial appendage irrespective of rhythm. Interstitial fibrosis is seen in >90% of patients distributed in both the atria and is independent of the rhythm. Amyloid and Aschoff bodies are uncommon and the rest of the changes are uniformly distributed across both the atria.

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