Correlation of Leptin Concentration in Gingival Crevicular Fluid on the Rate of Orthodontic Tooth Movement - A Prospective Study

Abstract

Background: The evaluation of genetic markers in the gingival crevicular fluid (GCF) and their connection to tooth movement can be helpful. Aim: The objective of this research is to assess the relationship involving leptin levels and orthodontic tooth movement (OTM). Study Setting and Design: Thirty individuals reporting to the Department of Orthodontics participated in an observational prospective study. Material and Method: Thirty orthodontic patients (15 male and 15 female) were included in the current study. The association of leptin concentration (GCF) was measured before and after orthodontic force was applied to move the mesially impacted canine distally (tooth movement distance on dental cast). Statistical Analysis: With the help of SPSS software version 21, the data were statistically examined using the “t” test, one-way ANOVA, and Bonferroni correction in Chicago. The average degree of tooth movement was calculated using Pearson’s correlation coefficient, and it was connected to the average leptin levels. Results: Average leptin levels in GCF elevated from baseline (T0, 285.315 picograms/micro litre) to 1 h after force application (T1, 384.683 pg/μL), then raised to a maximum at after 24 h (T2, 927.64 pg/μL), and decreased to the least amount after 15 days (T3, 29.26 pg/μL) and another time increase after two months (242.31 pg/μL). The degree of OTM was significantly correlated with the levels of leptin. Conclusion: While OTM was occurring, a biphasic fluctuation in the leptin level was noted. The amount of tooth movement was significantly correlated with the GCF leptin level.