Correlation of Lh and FSH With Sperm Analysis in Infertile Males

Abstract

BACKGROUNDInfertility has been defined as the inability of sexually active couple to achieve pregnancy despite of unprotected intercourse for a period of greater than 12 months. The failure of pituitary to secrete FSH and LH will result in disruption of testicular function resulting infertility. Analysis of semen and hormone evaluation are essential parameters in giving a definitive diagnosis in infertile males. The aim of the present study was to evaluate FSH and LH levels and correlate with sperm count, smoking, and alcohol intake in infertile men. MATERIALS AND METHODAll the necessary formalities were taken in maintaining the confidentiality of the patient's samples and ethical clearance from the Ethical Committee of Seven Hills Hospital, Visakhapatnam and NRIIMS, Sangivalasa, was taken. The present study was a prospective cross-sectional one carried out in Seven Hills Hospital and NRI Institute of Medical Sciences, Sangivalasa, Visakhapatnam. FSH, LH, Sperm analysis were done in 50 infertile males (38 were azoospermic and 12 were oligospermiac). RESULTSThe association of smoking and alcohol with infertility showed statistical insignificance. There was significant increase in serum concentrations of Follicle Stimulating Hormone (FSH) Levels (P=0.001) and serum concentrations of Luteinizing Hormone (LH) Levels (P=0.004). CONCLUSIONThe present study showed that the high level of gonadotropins is an indication of testicular problems as the cause of infertility.