Correlation of Lipid Profile and Glycated Hemoglobin as a New Prognostic Criterion for Type 2 Diabetes Mellitus Development and Progression

Abstract

The aim of the study was to assess correlations between the lipid profile and glycated hemoglobin in order to define their prognostic value as a criterion for the development and progression of type 2 diabetes mellitus (DM2) in individuals with metabolic syndrome and low body mass. Materials and Methods. The study included the results of examining 50 patients with metabolic syndrome (group 1), 50 with low body mass index (BMI) (group 2), 50 with DM2 (group 3), and 50 apparently healthy people (control group). Biochemical indices of the lipid profile and glycated hemoglobin in the venous blood were assessed using analyzers Clima MC-15 (Spain), BS-200, and BS-200 E (China). Results. It has been established that correlations of the parameters such as high-density lipoproteins (HDL), low-density lipoproteins (LDL), urea, and creatinine with BMI are expressed statistically more significantly in women in groups 1 and 2 in comparison with group 3, while in men the reverse situation is observed. Besides, correlation of triglyceride levels with BMI is statistically more marked in patients with DM2 than in apparently healthy people being positive in women and negative in men. Thus, HDL, LDL, creatinine, and urea may be diagnostically significant in the assessment of the development and progression of DM2 in men with metabolic syndrome since a strong positive correlation has been found between them and BMI, triglycerides were also found to be significant because a strong negative correlation has been detected between them and BMI. For women with metabolic syndrome, the combination of a weak correlation of BMI with the levels of HDL, LDL, urea, and creatinine and a strong positive correlation with triglycerides may be considered to be a prognostically significant index. Conclusion. New correlation characteristics of biochemical blood indices in DM2 may serve as prognostic criteria for disease development and progression.

Prevalence and Pattern of Dyslipidemia and Its Associated Factors Among Patients with Type 2 Diabetes Mellitus in Jordan: A Cross-Sectional Study

“…This finding confirms earlier results by others. 10 , 39 , 44 In addition, it has been estimated that a decline in the HbA1c level by 0.2% could lower the mortality rate by 10%. 45 But other studies disputed the significant difference between the serum concentrations of cholesterol and triglycerides with relation to HbA1c level.…”

“…[2][3][4] The relationship between T2DM and dyslipidemia could be bidirectional. While the risk of coronary artery disease (CAD) is two to four-fold higher in subjects with T2DM, 9 several studies have shown a significant correlation between glycated Hemoglobin (HbA1c) and multiple lipid profile parameters in patients with T2DM s. [10][11][12] Thus, effective control of one could positively affect the other.…”

Type-II-Diabetes Mellitus- Etiology, Epidemiology, Risk Factors and Diagnosis and Insight into Demography (Urban Versus Rural)

“…• Races: The disease is more common in some races and ethnic groups. • Age: Low HDL cholesterol and elevated triglycerides are associated with an increased risk of T2DM, especially in elderly [19]. • Polycystic ovary syndrome also increases diabetes risk.…”

A Cross-Sectional Study on Prevalence and Pattern of Dyslipidemia and Its Associated Factors among Patients with Type 2 Diabetes Mellitus

“…Ischemic heart disease, a reduction in life expectancy, and stroke are all higher risks associated with diabetes [1,2]. Diabetic patients are significantly at increased risk for cardiovascular disease due to dyslipidemia, which is considered an irregular lipid profile, caused by insulin resistance [3]. As a result of the metabolic syndrome and insulin resistance, transporting free fatty acids to the liver through the portal circulation, enhancing lipolysis [4,5].…”