Correlation of magnesium levels in cord blood and maternal serum among pre‐eclamptic pregnant women treated with magnesium sulfate

Boriboonhirunsarn, Dittakarn; Lertbunnaphong, Tripop; Suwanwanich, Morakot

doi:10.1111/j.1447-0756.2011.01702.x

Cited by 9 publications

(13 citation statements)

References 21 publications

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“…A previous veterinary research reported that tagged magnesium was actively concentrated in pregnant rabbit placenta which was instantly taken-up by the foetal tissues. 17 The same mechanism thought to happen among humans also and could be responsible for the high magnesium levels detected in cord blood, 18 similar to our study's findings. Magnesium freely moves across the placenta, therefore babies of mothers treated antenatally with MgSO 4 might have temporary high magnesium levels during their first days of early neonatal life.…”

Section: Discussionsupporting

confidence: 92%

Correlation of neonatal and maternal serum magnesium levels in pre-eclamptic women

Altraigey¹,

Mostafaa²

2019

MOJWH

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Background: Pre-eclampsia carries high risk for pregnant women and their babies to develop a wide range of adverse outcomes. Unfortunately, some medications used in its management causes serious side effects if they were not monitored properly. Magnesium sulphte, being widely used in controlling and preventing convulsions in cases of severe preeclampsia, should be utilized cautiously by monitoring of its serum levels.Objective: The aim of this study was to correlate between cord blood and maternal serum magnesium levels in pre-eclamptic women received magnesium sulphate before delivery. Patients and Methods: Cohort study on 36 pregnant women, more than 28 weeks' gestation, with the diagnosis of pre-eclampsia, who received magnesium sulphate (MgSO4), were recruited. Blood samples obtained from both maternal serum and cord blood was collected instantly at the time of delivery for detection of magnesium as well as calcium levels.Results: 94.5% were diagnosed with pre-eclampsia, while the rest had HELLP syndrome. The treated women received total mean MgSO4 of 14.4±6.0 grams during a mean duration of 5.1±3.3 hours. Mean±SD of maternal and cord magnesium levels were (2.2±0.4mmol/L) and (1.8±0.3mmol/L), respectively. Significant positive correlation (P<0.001) between maternal magnesium and calcium levels was detected. Also, the total dose as well as the MgSO4 duration with maternal and cord blood magnesium levels showed significant positive correlation (P<0.001), but with inverse correlation with both mother's and early neonatal calcium levels. Conclusion: Magnesium and calcium detected in maternal serum and cord blood had correlated levels in pre-eclamptic women who were treated with MgSO 4 therapy. As strong correlations of both magnesium and calcium between the mothers and their fetuses were demonstrated, health-care providers could use such information to give better and safer care for these patients.Citation: Altraigey A, Mostafaa ST. Correlation of neonatal and maternal serum magnesium levels in pre-eclamptic women.

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Section: Discussionsupporting

confidence: 92%

Correlation of neonatal and maternal serum magnesium levels in pre-eclamptic women

Altraigey¹,

Mostafaa²

2019

MOJWH

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“…This study demonstrated that maternal and neonatal blood magnesium concentrations are correlated following antenatal administration of magnesium sulphate. Recent studies have shown that magnesium concentrations in maternal blood among pre-eclamptic women correlate with magnesium concentrations measured from cord blood, which corroborates earlier work by Mittendorf et al who reported that maternal antecubital venous serum ionized magnesium sulphate concentrations were highly correlated with umbilical cord venous samples [20,21]. Hallak et al [22] also reported that magnesium concentrations in foetal serum and amniotic fluid were correlated with maternal magnesium concentrations following a 3-hr continuous intravenous infusion of magnesium sulphate.…”

Section: Discussionsupporting

confidence: 76%

“…Recent studies have shown that magnesium concentrations in maternal blood among pre‐eclamptic women correlate with magnesium concentrations measured from cord blood, which corroborates earlier work by Mittendorf et al . who reported that maternal antecubital venous serum ionized magnesium sulphate concentrations were highly correlated with umbilical cord venous samples . Hallak et al .…”

Section: Discussionmentioning

confidence: 97%

Maternal Magnesium Sulphate Exposure Predicts Neonatal Magnesium Blood Concentrations

Sherwin

Balch

Campbell

et al. 2013

Basic Clin Pharma Tox

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Tocolytic use of magnesium sulfate is associated with excess neonatal mortality and has been proposed to follow a dose-response relationship. This study aimed to define the correlation between maternal and neonatal magnesium blood concentrations. Magnesium blood concentrations were retrospectively obtained for mother-neonate pairs who were cared for at an Intermountain Healthcare facility from 1/2009-10/2011.

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“…; Boriboonhirunsarn et al . ; Borja‐Del‐Rosario et al . ), depending on the duration of the maintenance infusion and the timing of the sample relative to delivery.…”

Section: Discussionmentioning

confidence: 99%

Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep

Galinsky

Davidson

Drury

et al. 2015

The Journal of Physiology

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Key pointsr Magnesium sulphate is the recommended treatment for pre-eclampsia and is now widely recommended for perinatal neuroprotection.r MgSO 4 has vasodilatory and negative inotropic effects; however, it is unknown whether it impairs the cardiovascular and cerebrovascular adaptations to acute asphyxia in preterm fetuses.r Intravenous infusion of a clinically comparable dose of MgSO 4 to the preterm fetus was associated with no change in blood pressure, reduced fetal heart rate and increased femoral arterial conductance and blood flow; femoral arterial waveform height and width were increased, consistent with increased stroke volume during MgSO 4 infusion.r During asphyxia MgSO 4 was associated with increased carotid and femoral arterial conductance and blood flows; after asphyxia, fetal heart rate was lower and carotid and femoral blood flows and vascular conductance were greater in MgSO 4 -treated fetuses.r These data demonstrate that MgSO 4 may increase perfusion of peripheral vascular beds during adverse perinatal events such as asphyxia.Abstract Magnesium sulphate is a standard therapy for eclampsia in pregnancy and is widely recommended for perinatal neuroprotection during threatened preterm labour. MgSO 4 is a vasodilator and negative inotrope. Therefore the aim of this study was to investigate the effect of MgSO 4 on the cardiovascular and cerebrovascular responses of the preterm fetus to asphyxia. Fetal sheep were instrumented at 98 ± 1 days of gestation (term = 147 days). At 104 days, unanaesthetised fetuses were randomly assigned to receive an intravenous infusion of MgSO 4 (n = 6) or saline (n = 9). At 105 days all fetuses underwent umbilical cord occlusion for 25 min. Before occlusion, MgSO 4 treatment reduced heart rate and increased femoral blood flow (FBF) and vascular conductance compared to controls. During occlusion, carotid and femoral arterial conductance and blood flows were higher in MgSO 4 -treated fetuses than controls. After occlusion, fetal heart rate was lower and carotid and femoral arterial conductance and blood flows were higher in MgSO 4 -treated fetuses than controls. Femoral arterial waveform height and width were increased during MgSO 4 infusion, consistent with increased stroke volume. MgSO 4 did not alter the fetal neurophysiological or nuchal electromyographic responses to asphyxia. These data demonstrate that a clinically comparable dose of MgSO 4 increased FBF and stroke volume without impairing mean arterial pressure (MAP) or carotid blood flow (CaBF) during and immediately after profound asphyxia. Thus, MgSO 4 may increase perfusion of peripheral vascular beds during adverse perinatal events.

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Correlation of magnesium levels in cord blood and maternal serum among pre‐eclamptic pregnant women treated with magnesium sulfate

Abstract: Maternal serum magnesium and calcium levels were correlated with cord blood levels in pre-eclamptic pregnant women who received MgSO4 therapy.

Cited by 9 publications

References 21 publications

Correlation of neonatal and maternal serum magnesium levels in pre-eclamptic women

Correlation of neonatal and maternal serum magnesium levels in pre-eclamptic women

Maternal Magnesium Sulphate Exposure Predicts Neonatal Magnesium Blood Concentrations

Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep

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