Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease

Başaran, Recep; Şenol, Mehmet Güney; Özkanlı, Şeyma; Efendioğlu, Mustafa; Kaner, Tuncay

doi:10.1016/j.jocn.2017.03.001

Cited by 23 publications

(20 citation statements)

References 15 publications

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“…The degradation of the matrix is in equilibrium with the synthesis of the new matrix [ 28 ]. Bone morphogenetic protein-2 (BMP-2), insulin-like growth factor-1, BMP-7 (also known as osteogenic protein-1), growth differentiation factor 5, and transforming growth factor- β can stimulate the synthesis of matrix [ 29 ]. On the contrary, TNF- α and IL-1 inhibit the synthesis of extracellular matrix and improve their catabolism [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Bone morphogenetic protein-2 (BMP-2), insulin-like growth factor-1, BMP-7 (also known as osteogenic protein-1), growth differentiation factor 5, and transforming growth factor- β can stimulate the synthesis of matrix [ 29 ]. On the contrary, TNF- α and IL-1 inhibit the synthesis of extracellular matrix and improve their catabolism [ 29 ]. The balance of synthesis and degradation in the disc matrix determines the integrity of the intervertebral disc [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway

Liang

Dai

et al. 2018

Disease Markers

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We first applied moderate fluid shear stress to nucleus pulposus cells. The correlation of AP-1 with type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 and the correlation of AP-1 with IL-1β, TNF-α, IL-6, IL-8, MIP-1, MCP-1, and NO were detected. Our results document that moderate fluid shear stress could activate the FAK-MEK5-ERK5-cFos-AP1 signaling pathway. AP1 could downregulate the construct factors of cytoskeleton such as type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 in nucleus pulposus cell after the fluid shear stress was loaded. AP1 could upregulate the inflammatory factors such as IL-1β, TNF-α, IL-6, IL-8, MIP-1, MCP-1, and NO in nucleus pulposus cell after the fluid shear stress was loaded. Taken together, our data suggested that moderate fluid shear stress may play an important role in the cytoskeleton of nucleus pulposus and surrounding inflammatory mediators by activating the FAK-MEK5-ERK5-cFos-AP1 signaling pathway, thereby affecting cell degeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway

Liang

Dai

et al. 2018

Disease Markers

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“…The maximum total score is 20. Studies could be divided into three grades: grade A (high quality, scored [15][16][17][18][19][20], grade B (medium quality, scored [8][9][10][11][12][13][14], and grade C (low quality, scored 0-7).…”

Section: Methodological Qualitymentioning

confidence: 99%

“…The etiology of LDD is unclear, but various genetic and environmental factors have been identified [5][6][7]. Recently, increasing evidence suggested that several genes, such as interleukins (ILs), collagen IX, and matrix metalloproteinases (MMPs), play a vital role in the initiation and progression of LDD [8,9].…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study

Guan

Wang

et al. 2020

J Orthop Surg Res

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Background: To investigate the association between interleukin-6 (IL-6) (rs1800795, rs1800796, rs1800797, rs13306435, rs2069849) and interleukin-10 (IL-10) (rs1800871, rs1800896) gene polymorphisms, expression levels, and lumbar disc disease (LDD). Methods: We conducted a literature research on PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI) until February 28, 2019. We included all case-control studies about the association between IL-6 and IL-10 gene polymorphisms and LDD. The odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the strength of association. Statistical analysis was conducted by Review Manager (RevMan) 5.3 software. Furthermore, immunohistochemistry (IHC) and RT-PCR were performed to evaluate IL-6 and IL-10 expressions in the normal and degenerated disc. Results: A total of 6 studies, involving 1456 cases and 1611 controls, were included in this meta-analysis. G alleles of rs1800795 and rs1800797 in the IL-6 gene were significantly associated with LDD (rs1800795: G vs. C, OR = 1.38, 95% CI = 1.16-1.64, P = 0.0002; rs1800797: G vs. A, OR = 1.35, 95% CI = 1.14-1.61, P = 0.0006). Begg's funnel plot and Egger's tests did not show any evidence of publication bias. IL-6 expression and IL-6 mRNA levels were significantly increased in the degenerated disc compared with those in the normal disc (IL-6 immunopositive cells, 73.68 ± 10.99% vs. 37.23 ± 6.42%, P < 0.001). Conclusions: IL-6 gene polymorphisms (rs1800795 and rs1800797) were significantly associated with susceptibility to LDD. A high expression level of IL-6 may be an important risk factor for LDD.

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“…A great many genes have now been shown to be related to lumbar disc herniation, including MMP [ 7 , 8 ], VDR [ 9 ], FAS [ 10 ] and COL [ 11 ] et al It is generally believed that neuroin- flammation plays a crucial role in the development of chronic pain [ 12 ]. It has been more and more is convinced of that lumbar disc pain may be pathophysiologically induced by chemical inflammation, inflammatory cytokines are not only closely related to other cytokines and chemical mediators but also play an important role in lumbar disc herniation, although the inflammatory factors that contribute to lumbar disc herniation and pain remain to be determined [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Association between IL4, IL6 gene polymorphism and lumbar disc degeneration in Chinese population

Zhu

Niu

et al. 2017

Oncotarget

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Lumbar disc disease (LDD) is a common musculoskeletal disorder, caused by degeneration of intervertebral discs of the lumbar spine and is one of the most common musculoskeletal disorders affliction in adult. There is growing evidence that LDD has strong genetic determinants. We analyze whether the IL4 and IL6 gene polymorphism is related to LDD in Chinese Han population. The participants were 498 with LDD and 463 without LDD. IL4 and IL6 gene polymorphism were determined by Sequenom MassARRAY. We found that SNPs rs1800796(OR = 1.29, 95% CI, 1.07 – 1.57, p = 0.009), rs1524107(OR = 1.28, 95% CI, 1.05 – 1.55, p = 0.013), rs2069840 (OR = 1.39, 95% CI, 1.03 – 1.89, p = 0.033) in IL6 gene were significantly associated with LDD risk at a 5% level. In addition, genetic models found IL4 gene (rs2243250) were associated with LDD. In this study, we analyzed and associated SNPs of IL4 and IL6 with LDD risk. In summary, four variations (rs1800796, rs1524107, rs2069840, rs2243250) of the selected candidate SNPs were associated with susceptibility to LDD in our study. The results of this study have the guiding significance in clinical work in the future in the treatment of lumbar disc herniation patients, not one-sided that the symptoms of low back pain only from mechanical oppression.

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Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease

Cited by 23 publications

References 15 publications

Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway

Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway

Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study

Association between IL4, IL6 gene polymorphism and lumbar disc degeneration in Chinese population

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