Correlation of matrix metalloproteinases–1 and –3 with patient age and grade of lumbar disc herniation

Zigouris, Andreas; Batistatou, Anna; Alexiou, George Α.; Pachatouridis, Dimitrios; Mihos, Evaggelos; Drosos, Dimitrios; Fotakopoulos, George; Doukas, Michail; Voulgaris, Spyridon; Kyritsis, Athanasios P.

doi:10.3171/2010.9.spine09935

Cited by 32 publications

(33 citation statements)

References 39 publications

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“…A different lumbar disc herniation study by the same author reported a strong correlation between MMP-1 and MMP-3 expressions and the patients' age and herniation grade. In terms of pathogenesis of lumbar disc herniation, the same study reported that MMP-1 expression was higher than that of MMP-3 in the young group of patients (25).…”

Section: Discussionmentioning

confidence: 95%

The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc hernias

Özkanlı¹,

Kaner²,

Efendioğlu³

et al. 2014

Turkish Neurosurgery

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AIm: In this study, our aim was to examine if matrix metalloproteinase expressions (MMP-1, MMP-2, MMP-3) in patients operated with a lumbar disc hernia diagnosis are different in terms of clinical and neuroradiological findings. mATErIAl and mEThOds:The study included 80 patients treated with micro discectomy for lumbar disc hernia. Degeneration was scored via magnetic resonance (MR) images. MMP-1, MMP-2, and MMP-3 antibodies were used for immunohistochemical evaluation of degenerated disc materials. MMP expressions were compared between primary and recurrent cases, and correlation analysis was conducted.rEsulTs: Discectomy material showed higher expression of MMP-1 and MMP-3 in cases of recurrent lumbar disc herniation than in primary herniation. There was no significant relationship between MMP expression and MR degeneration score.CONClusION: MMP-1 and MMP-3 expressions were significantly higher in recurrent cases in terms of magnetic resonance degeneration score. We assume that the higher co-expression of MMP-1 and MMP-3 might be used in targeted treatment regiemens in patients with recurrent LDH.KEywOrds: Lumbar disc herniation, Matrix metalloproteinase, Pfirrmann classification, Recurrent disc herniation ÖZ AmAÇ: Çalışmada primer ve nüks lomber disk hernisi (LDH) tanısı ile ameliyat edilen hastalarda matriks metalloproteinaz (MMP-1, MMP-2, MMP-3) ekspresyonlarının değişik klinik ve nöroradyolojik bulgularla karşılaştırılması amaçlandı. yÖNTEm ve GErEÇlEr: Hastanemizde LDH tanısı ile mikrodiskektomi uygulanan 80 olgu çalışmaya dahil edildi. İntervertebral alandan alınan dejenere disk materyali patoloji kliniğinde histokimyasal olarak Hematoksilen-Eozin boyası ile değerlendirildikten sonra MMP-1, MMP-2 ve MMP-3 antikorları kullanılarak immünohistokimyasal inceleme yapılmıştır. MMP ekspresyonları primer ve rekürren olgularda karşılaştırılıp, korelasyon analizi yapılmıştır.BulGulAr: MMP-1 ve MMP-3 ekspresyonu nüks olgularda primer olanlara göre daha yüksek bulunmuştur. MMP ekspresyonu ile MR dejenerasyon skoru arasında anlamlı bir ilişki yoktur. sONuÇ: Nüks lomber disk hernilerinde MMP-1 ve MMP-3 ekspresyonu primer olgulara göre istatistiksel olarak anlamlı yüksek bulunmuştur. MMP-1 ve MMP-3, LDH'lu olgularda yüksek oranda ekspresyonunun hedef tedavi protokollerinde kullanılabileceğini düşünmekteyiz.ANAhTAr sÖZCÜKlEr: Lomber disk herniasyonu, Matriks metalloproteinaz, Pfirrmann sınıflaması, Nüks disk herniasyonu

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Section: Discussionmentioning

confidence: 95%

The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc hernias

Özkanlı¹,

Kaner²,

Efendioğlu³

et al. 2014

Turkish Neurosurgery

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“…The main pathological features of rheumatoid arthritis (RA) are synovitis and irreversible joint erosion (Zigouris et al, 2011). It has been shown that matrix metalloproteinases (MMPs), a family of enzymes that can degrade extracellular matrix proteins, can mediate the occurrence and development of RA (Klein and Bischoff, 2011).…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis

Mj¹,

et al. 2015

Genet. Mol. Res.

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“…The disintegration of the IVD is primarily executed by proteinases (9,16). Among these proteinases, matrix metalloproteinase 3 (MMP-3, stromelysin-1) has been found in increased concentrations and has been evaluated as an important element in IVD degeneration (1,27).MMP-3 is efficient at degrading non-collagenous extracellular matrix including; proteoglycans, gelatin, fibronectin and laminin; additionally, MMP-3 is capable of activating latent collagenases (matrix metalloproteinase 1) (5, 9, 23).…”

Section: Introductionmentioning

confidence: 99%

Correlation of matrix metalloproteinase–3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration

Canbay

Turhan²,

Bozkurt³

et al. 2012

Turkish Neurosurgery

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AIm:The purpose of the present study is to analyze the expression of matrix metalloproteinase-3 (MMP-3), magnetic resonance imaging (MRI) grading and histopathological alterations of the intervertebral disc (IVD) for correlations with each other and with the age, gender and low back pain duration of the patients who had undergone operations for lumbar disc herniation (LDH). mAterIAl and methOds: Forty-two patients were admitted to our clinic with signs of LDH and underwent surgery for LDH at 48 IVD levels. In all cases, specimens for histological and immunohistochemical analyses were removed from the IVD space. Lumbar IVD degeneration on MRI of the 48 IVDs from which surgical specimens had been obtained was classified into five grades using the Pfirrmann classification. results:In the degenerated IVD, the expression of MMP-3, MRI grading and histopathological alterations of the IVD displayed significant correlation. Increased age is closely related with aforementioned alterations. There was no correlation between MMP-3 expression and age, gender and duration of the pain.COnClusIOn: For evaluating and treating IVD degeneration, MRI is a good and non-invasive diagnostic tool to determine the severity of degeneration. MMP-3 may be a therapeutic target of the degenerated IVD.KeywOrds: Disc degeneration, Histopathological changes, Matrix metalloproteinase-3, Magnetic resonance imaging ÖZ AmAÇ: Bu çalışmanın amacı lomber disk hernisi (LDH) tanısı ile ameliyat edilen hastalarda matriks metaloproteinaz-3 (MMP-3) ekspresyonunun manyetik rezonans (MR) görüntüleme bulguları, diskdeki histopatolojik değişiklikler, hasta yaşı, cinsiyeti ve ağrının süresi ile olan ilişkisini araştırmaktır. yÖntem ve GereÇler: Kırkiki adet LDH tanısı konulmuş olan hasta kliniğimize müracaat etmiş ve toplam 48 adet intervertebral disk seviyesinden opere edilmiştir. Tüm olgularda intervertebral disk aralığından alınan örnekler histolojik ve immünhistokimyasal incelemeye tabii tutulmuştur. MR görüntülerindeki lomber disk dejenerasyonu Pfirrmann sınıflandırmasına gore 5 dereceye ayrılmıştır. BulGulAr:Dejenere intervertebral disk örneklerinde MMP-3 ekspresyonu, MR derecesi ve histopatolojik değişiklikler arasında anlamlı ilişkili tesbit edilmiştir. Yaş arttıkça bu ilişki daha belirgin hale gelmiştir. MMP-3 ekspresyonu ile hasta yaşı, cinsiyeti ve ağrı süresi arasında anlamlı bir ilişki yoktur. sOnuÇ: İntervertebral disk dejenerasyonunun değerlendirilmesi ve tedavi edilmesi için MR çok iyi ve non-invaziv bir tanı metodudur. Bu aynı zamanda disk dejenerasyonunun ciddiyetini de gösterir. MMP-3 dejenere intervertebral disk hernilerinde tedavinin hedefi olabilir.

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Correlation of matrix metalloproteinases–1 and –3 with patient age and grade of lumbar disc herniation

Cited by 32 publications

References 39 publications

The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc hernias

The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc hernias

Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis

Correlation of matrix metalloproteinase–3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration

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Correlation of matrix metalloproteinases–1 and –3 with patient age and grade of lumbar disc herniation

Cited by 32 publications

References 39 publications

The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc hernias

The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc hernias

Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis

Correlation of matrix metalloproteinase&#8211;3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration

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Correlation of matrix metalloproteinase–3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration