Correlation of Metabolic Disorders and FOXO Signaling in AD: A Therapeutic Approach

Abstract

Alzheimer’s Disease is an ailment that is linked with the degeneration of the brain cells and this illness is the main cause of dementia. Metabolic stress affects the activity of the brain in AD via FOXO signaling. The occurrence of AD will significantly surge as the world’s population will age along with lifestyle changes perceived in current decades giving the impression of main contributors to such augmented prevalence. Similarly, metabolic disorders of current adulthood, such as obesity, liver, stroke, and diabetes mellitus, have been observed as the risk-causing factors of AD. FOXO transcription factors are preserved molecules that play an important part in assorted biological progressions, precisely in aging as well as metabolism. Here, we capitulate the signaling pathways along with the cellular functions of FOXO proteins. We have also summarized the intricate role of FOXO in AD, with a focus on metabolic stress, and discussed the prospect of transcriptional alterations with respect to FOXO as a molecular link between AD and metabolic disorders.