Correlation of microRNA-367 in the clinicopathologic features and prognosis of breast cancer patients

Abstract

Breast cancer (BC) is a malignant tumor originating from cells of the breast. Notably, microRNAs have been recognized as biomarkers of BC metastasis. The present study is designed to evaluate the association between microRNA (miR)-367 expression and BC with the variance of clinicopathologic features and prognosis. Initially, 63 BC patients were allocated in the BC group, while the other 40 healthy volunteers were recruited as the control group. miR-367 expression in the serum of patients and healthy controls was detected using real-time polymerase chain reaction. Furthermore, the relation between miR-367 in serum and clinicopathologic features and prognosis of BC patients was accessed. miR-367 expression in serum of the BC group was evidently lower than that in the control group (all P < .001). Besides, miR-367 underexpression in the BC group was closely associated with the variance in tumor nodes metastasis advanced stage, tumor diameter, and lymph node metastasis of BC (all P < .001). In addition, compared with the control group, poorly expressed miR-367 BC group had short period of disease-free survival and overall survival (all P < .001). Our study demonstrated that miR-367 expression is associated with BC clinicopathologic features and prognosis. This investigation may offer new insight for BC treatment.

Dysregulated expression of miR‑367 in disease development and its prospects as a therapeutic target and diagnostic biomarker (Review)

“…The results of the study demonstrated that low expression of miR-367-3p was associated with positive ALNM, larger tumor size and a more advanced tumor-node-metastasis stage (30). In addition, a study conducted by Liu et al (31) revealed a strong association between miR-367 expression and the clinicopathologic features and prognosis of breast cancer. It was found that the miR-367 expression level in the serum of patients with breast cancer was significantly lower than that of the control group.…”

“…Extensive cancer research has focused on miR-367, which has demonstrated tumor-suppressing activity through the targeting of oncogenes. In multiple types of cancer, including breast (30)(31)(32), gastric (33,34) and prostate cancer (35), higher levels of miR-367 have been associated with improved prognoses and survival rates. In addition, miR-367 has been recognized as a possible biomarker for diagnosing various types of cancer including breast (30,31) and gastric (33) cancer (Fig.…”

“…Breast cancer is a common cancer mainly found in women, accounting for 11.7% of all cancer diagnoses and 6.9% of cancer-related deaths globally in women (36). Studies have shown that miRNAs can be either upregulated (37) or downregulated (30,31) in patients with breast cancer and different levels can distinguish these patients from healthy individuals. Studies have shown that miR-367 is involved in the development and progression of breast cancer, and its dysregulation has been implicated in various aspects of breast cancer biology, including cell proliferation, apoptosis, invasion and metastasis (32,38).…”

The clinical validity of miR-126 as a prognostic marker in epithelial ovarian cancer

“…Differentially expressed miRNA may be used as the indicator of early diagnosis, molecular typing and prognosis, including ovarian cancer. [5][6][7] microRNA (miR-126), originally identified as an endothelial-specific miRNA playing an essential role in angiogenesis and vascular integrity, [8,9] it has been shown to function as a critical tumor suppressor in various types of solid tumors. [10][11][12][13] Overexpressed miR-126 can inhibit drug resistance cell proliferation and promote apoptosis of drug resistance cell, and invasion of cancer cells in various types of solid tumors.…”

“…Differentially expressed miRNA may be used as the indicator of early diagnosis, molecular typing and prognosis, including ovarian cancer. [5–7] microRNA (miR-126), originally identified as an endothelial-specific miRNA playing an essential role in angiogenesis and vascular integrity, [8,9] it has been shown to function as a critical tumor suppressor in various types of solid tumors. [10–13]…”