Correlation of Nitric Oxide (NO) and Corticotrophin Releasing Hormone (CRH) between Normal Pregnancy and Preeclampsia

Abstract

Preeclampsia is still a major cause of maternal death in pregnancy which needs efforts to prevent and early detection. Nitric oxide and Corticotrophin Releasing Hormone has an important role in the pathogenesis of preeclampsia to determine differences in concentrations of NO and CRH in normal pregnancy and preeclampsia, as well as to study the correlation both on the incidence of preeclampsia. This is a cross sectional study. Blood samples obtained from patients with preeclampsia (30 samples) and normal pregnancies as controls (30 samples) in accordance with inclusion and exclusion criteria. NO concentration was examined with essay protocol, and CRH concentrations with ELISA method. Then be calculated by statistical analysis: chi square, t test, Mann-Whitney, and Spearman Rank correlation coefficient. Based on statistical analysis, there was no significant difference (p > 0.05) from the characteristics of maternal age, pregnancy weeks, and parity in both study groups, so the two groups of homogeneous and comparable. The mean concentration of NO in preeclampsia was lower (3.780 µM) compared with normal pregnancy (13.360 µM). There was significant correlation between NO and CRH concentrations in normal pregnancy and preeclampsia (p < 0.001). The involvement of NO/c-GMP pathway is very possible in the pathogenesis of preeclampsia.

Corticotrophin Releasing Hormone; As a Useful Marker to Identify the Pre-eclampsia

“…Recent studies revealed that CRH level has negative correlation with the length of gestation and leads to preterm birth 9 . CRH plays vital role in pathogenesis of pre-eclampsia 10 . Increased levels of CRH affects CRH-R receptors, CRH-R receptor can be used as a biomarker for prediction of preeclampsia 11 .…”