Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients

Abstract

We decided to assess the prognostic value of NLRP3 inflammasome level in acute coronary syndrome (ACS) patients and whether it was related to coronary atherosclerotic severity. Study population included one-hundred and twenty-three (123) subjects. Peripheral blood monocyte NLRP3 protein level was correlated with clinical presentation, angiographic characteristics and its scoring systems as well as GRACE and TIMI risk scores. Follow-up for major adverse cardiac events (MACE) was carried out at 180 days. Peripheral blood monocyte NLRP3 was found to be elevated in ACS patients (P < 0.05) and showed positive correlation with GRACE score (r = 0.619), TIMI score (r = 0.580), SYNTAX score (r = 0.550), Clinical SYNTAX score (r = 0.564) and Gensini score (r = 0.516). NLRP3 was also increased with increasing number of vessels, the number of lesions present and the presence bifurcation lesions (P < 0.05). Multivariate Cox regression analysis showed NLRP3 to be an independent predictor of MACE (P = 0.043). Kaplan-Meier analysis and receiver operating characteristic curves for NLRP3 showed good predictive value for MACE. There is a positive correlation of NLRP3 level with severity of coronary atherosclerosis. NLRP3 level is a promising prognostic utility and is efficient in event prediction for MACE.

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“…Recent studies have reported that inflammasomes contribute to the pathogenesis of several agerelated metabolic diseases, including atherosclerosis [86][87][88][89] and Alzheimer's disease [90][91][92][93][94][95].…”

NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis

“…In ACS patients, NLRP3 is positively correlated with the degree of AS by clinical scores and lesion characteristics [70]. is study showed that the baseline concentration of NLRP3 was a promising prognostic index that effectively predicted MACE events through Grace and TIMI risk scores [70].…”

“…e expression of NLRP3 in ascending aorta tissues of patients with coronary artery bypass grafting (CABG) is significantly higher than that of patients without AS, and it is positively correlated with the lesion degree of AS and risk factors of AS [67]. NLRP3 in the aorta was significantly correlated with the severity score of Gensini on the coronary artery [70]. e relevant components in the inflammasome signaling pathway of NLRP3, ASC, caspase-1, IL-1β, and IL-18 are highly expressed in human carotid atherosclerotic plaques, while expression in healthy mesenteric arteries is weak [68].…”

“…e expression of NLRP3-mRNA in the plaques of symptomatic AS patients is higher than that of asymptomatic AS patients [69]. Compared with non-CHD (nonchronic heart disease) patients, patients with CHD, especially those with acute coronary syndrome (ACS), have higher levels of mRNA and protein in peripheral blood of the NLRP3 inflammasome [70]. In ACS patients, NLRP3 is positively correlated with the degree of AS by clinical scores and lesion characteristics [70].…”

“…Compared with non-CHD (nonchronic heart disease) patients, patients with CHD, especially those with acute coronary syndrome (ACS), have higher levels of mRNA and protein in peripheral blood of the NLRP3 inflammasome [70]. In ACS patients, NLRP3 is positively correlated with the degree of AS by clinical scores and lesion characteristics [70]. is study showed that the baseline concentration of NLRP3 was a promising prognostic index that effectively predicted MACE events through Grace and TIMI risk scores [70].…”