Correlation of nocturnal increase in plasma oxytocin with a decrease in plasma estradiol/progesterone ratio in late pregnancy

Fuchs, Anna‐Riitta; Behrens, Otto K.; Liu, Hung-Ching

doi:10.1016/0002-9378(92)91739-w

Cited by 57 publications

(34 citation statements)

References 21 publications

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“…In contrast to Bakker et al, in primipare late term women, we have found that labor duration and active phase length of labor is shorter in the evening group than in the morning group. Our results can be explained by circadian rhythm of oxytocin concentration that was documanted by human and animal studies [10][11][12][13][14][15]. Oxytocin concentrations and myometrial oxytocin receptors increase during evening and night time with a decreased estradiol/progesterone ratio.…”

Section: Discussionsupporting

confidence: 54%

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

Kokanali¹,

Cavkaytar²,

Topçu³

et al. 2016

Ann Clin Anal Med

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ÖzetGiriş: Intravenöz oksitosin infüzyonu ile doğum indüksiyonu sabah ya da akşam başlatılan geç-term gebeliklerin sonuçlarını incelemek. Gereç ve Yöntem: Sefalik prezantasyonda tekil gebeliğe sahip, gebelik yaşı 41 0/7 haftadan 41 6/7 haftaya kadar olan 266 tane gebe bu retrospektif çalışmaya katılmıştır. İntravenöz oksiosin ile doğum indüksiyonları sabah saatlerinde (08.00-12.00) ya da akşam saatlerinde (16.00-20.00) başlatılmıştır. Doğum sonuçları ve gece saatlerindeki (20.00-08.00) doğumlar kaydedilmiştir. Bulgular: Primipar gebelerde, doğum eylemi süresi, doğum eyleminin aktif faz uzunluğu akşam grubunda sabah grubuna göre anlamlı olarak daha kısaydı. Multipar gebelerde, gece saatlerinde doğum oranı akşam grubunda sabah grubuna göre anlamlı derecede daha fazla idi. Ayrıca gece saatlerinde doğum, yenidoğan yoğun bakım ünitesine başvurmak için anlamlı bir risk faktörü olarak bulundu. Tartışma: İntravenöz oksitosin infüzyonu ile akşam başlatılan doğum indük-siyonu, primipar gebelerde doğum eylemi süresini kısaltırken multipar gebelerde kısaltmaz. Gece saatlerindeki doğum kötü perinatal sonuç için risk faktörü olabilir. Doğum indüksiyonu planlanırken, parite, indüksiyon başlama zamanı ve tahmini doğum saati olası kötü neonatal sonuçları azaltmak için dikkate alınmalıdır.Anahtar Kelimeler Doğum İndüksiyonu; Oksitosin; Sabah; Akşam Abstract Aim: We aimed to investigate the labor outcomes of late-term pregnancies underwent intravenous oxytocin induction starting in the morning compared with starting in the evening. Material and Method: 266 women with a singleton pregnancy in cephalic presentation, at gestational age of 41 0/7 through 41 6/7 weeks were enrolled in this retrospective study. Labor inductions with intravenous oxytocin were started in the morning hours (08.00-12.00) or in the evening hours (16.00-20.00). Labor outcomes and night-time (20.00-08.00) deliveries were recorded. Results: In primiparae group, labor duration and active phase length of labor were significantly shorter in the evening group than in the morning group. In multiparae women, the ratio of nighttime delivery was significantly higher in evening group as compared to morning group. And also night-time delivery was found as a significant risk factor for neonatal intensive care unit admission. Discussion: Induction of labour with intravenous oxytocin starting in the evening shortens labor duration in primiparae women, but not in multiparae women. Night-time delivery may be a risk for poor perinatal outcome. As the labor induction is planned, parity, start time of induction and estimated delivery time should be taken into account to reduce the risk of poor neonatal outcome in late-term pregnancies.

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Section: Discussionsupporting

confidence: 54%

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

Kokanali¹,

Cavkaytar²,

Topçu³

et al. 2016

Ann Clin Anal Med

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“…Then, the analytical signals were filtered with a secondorder Butterworth band-pass filter with cutoff frequencies of 0.3 Hz-45 Hz. Finally, the power spectra of these complex analytical uterine signals were accomplished using equation (1).…”

Section: The Signal Analysis Methodsmentioning

confidence: 99%

“…Plasma oxytocin throughout pregnancy is very low in the daytime and changes to the highest level at nighttime (1,2). This change has been reported to parallel diurnal changes in uterine contractions (2).…”

Section: Introductionmentioning

confidence: 91%

Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

Şimşek¹,

Parlakpınar²,

Turhan³

et al. 2014

J Turkish German Gynecol Assoc

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(2) melatonin applied as 0.4 mg/kg/IV (n=8); (3) melatonin applied as 4 mg/kg/IV (n=8); (4) single dose of oxytocin (100 mU/kg) injected IV (n=8); (5) melatonin (0.4 mg/kg) plus oxytocin (100 mU/kg) (n=8); and (6) melatonin (4 mg/kg) plus oxytocin (100 mU/kg) injected IV (n=8). Each rat underwent a laparotomy, and uterine myoelectrical signals were recorded. The mean spectrum, averaged over the spectral content of signals in each group, was compared. Results:Melatonin induced uterine myoelectrical activity in a dose-dependent manner. Treatment of melatonin after oxytocin suppressed the mean power of the signals. Serum melatonin concentrations were significantly higher in melatonin-treated rats. Conclusion:Melatonin itself at two different dose levels was found to be equally effective in stimulating the uterine electrical signals, although oxytocin-induced uterine electrical activity was suppressed by melatonin. These findings merit further investigations on the possible beneficial role of melatonin in the treatment of conditions associated with abnormal uterine activity. (J Turk Ger Gynecol Assoc 2014; 15: 86-91) Key words: Uterine contraction, melatonin, oxytocin, electrical stimulation Received: 15 December, 2013 Accepted: 29 December, 2013 Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

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“…Oxytocin concentration has been shown to increase with estradiol administration [14,15] and in pregnancy there is evidence that the magnitude of the changes in circulating concentration is related to the estradiol/progesterone ratio [16]. A significant increase in Oxytocin levels has also been shown when women used oral contraceptives [17,18].…”

Section: Introductionmentioning

confidence: 99%

Mood and Oxytocin Blood Levels in Physically Active Women with and without Oral Contraceptive Use in Relation to Seasonal Daylight Variation

Frisén¹

2017

Int J Sports Exerc Med

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Correlation of nocturnal increase in plasma oxytocin with a decrease in plasma estradiol/progesterone ratio in late pregnancy

Cited by 57 publications

References 21 publications

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

Mood and Oxytocin Blood Levels in Physically Active Women with and without Oral Contraceptive Use in Relation to Seasonal Daylight Variation

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