Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing’s sarcoma

Masrouha, Karim; Musallam, Khaled M.; Samra, Alexis Bou; Tawil, Ayman; Haidar, Rachid; Chakhachiro, Zaher; Saghieh, Saïd; Abdallah, Abeer; Saab, Raya; Muwakkit, Samar; Abboud, Miguel R.; Khoury, Nabil

doi:10.1007/s00256-012-1383-8

Cited by 15 publications

(9 citation statements)

References 19 publications

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“…Masrouha et al evaluated the imaging appearance of these areas and found that when a "feathery pattern" was identified in the adjacent muscle or soft tissues, only normal tissue, edema, or fibrosis remained; however, when a "bulky" appearance was present, tumor was identified in >70% of the cases. 80 Even so, DEMRI is accurate in detecting macroscopic tumor invasion to within 5 mm, but microscopic tumor can extend 3 cm beyond the macroscopic margin. 77 The ultimate criterion for determining whether there has been a favorable response of the osteosarcoma to preoperative chemotherapy is determined by the histopathologic analysis.…”

Section: Mrimentioning

confidence: 99%

Osteosarcoma: Review of the Various Types with Emphasis on Recent Advancements in Imaging

Fox

Trotta

2013

Semin Musculoskelet Radiol

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Osteosarcoma is the classic malignant osteoid-forming bone tumor. The typical clinical presentation, histology, imaging findings, treatment, and prognosis for each subtype of osteosarcoma is provided. Particular emphasis is placed on more current magnetic resonance imaging and nuclear medicine imaging techniques that may soon improve the ability to determine the most appropriate therapy and ultimately improve patient survival.

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Section: Mrimentioning

confidence: 99%

Osteosarcoma: Review of the Various Types with Emphasis on Recent Advancements in Imaging

Fox

Trotta

2013

Semin Musculoskelet Radiol

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“…However, we know that there may be tumor cells in those areas. Masrouha et al 12 reported on 30 cases (27 osteosarcoma and 3 Ewing sarcoma) in which they found that 17.4% of these areas were positive for tumor (viable or necrotic). That is why we included all signal abnormalities in the MRI analysis.…”

Section: Discussionmentioning

confidence: 99%

Planning for Bone Excision in Ewing Sarcoma

Thévenin-Lemoine

Destombes

Vial

et al. 2018

The Journal of Bone and Joint Surgery

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“…Cañadell [9] considered the indications for epiphyseal distraction should include the following: 1) the tumor should be situated in the metaphyseal region; 2) the physeal cartilage should be open; and 3) the tumor should not transgress the physis and should be confirmed by radiography, arteriography, CT or MRI preoperatively and histological examination intraoperatively. At present, MRI is considered to be superior to X-ray and CT in determining the invasive range of malignant tumors of the limbs [16,17]. …”

Section: Discussionmentioning

confidence: 99%

Preliminary clinical research on epiphyseal distraction in osteosarcoma in children

et al. 2014

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BackgroundThe feasibility of distal femur epiphysis preservation through epiphyseal distraction by external fixator in childhood osteosarcoma was explored.MethodsBetween July 2007 and May 2011, 10 children who were suffering from distal femur osteosarcoma received epiphyseal distraction by external fixator, combined with tumor resection and repair with massive allograft bone to preserve the epiphysis of the distal femur and knee function. There were six male and four female patients, 9- to 14-years old (average 10.5 years old). The tumors were staged clinically according to the Enneking staging method: six cases were classified as stage in IIA and four cases as stage in IIB. All patients were diagnosed by biopsy, then received chemotherapy before and after surgery. All patients received tumor bone resection and the defects of the bone were repaired with massive allograft bone that was fixed by intramedullary nails; the distracted epiphysis and allograft bone were fixed with cancellous screws.ResultsAll cases received follow-up from 15 to 56 months (average 38.5 months). There were no local recurrences. One case died of lung metastasis and one case had poor incision healing for rejection of allograft bone. According to the functional evaluation criteria of the International Society of Limb Salvage (ISOLS) after operation, five cases were rated excellent, four cases good and one case fair. The ratio of excellent or good was 90.0%. There was no statistically significant difference in length between the operated and the normal lower limbs during the last review.ConclusionsEpiphyseal distraction by external fixator can result in satisfactory limb length and joint function for children with a malignant bone tumor.

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Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing’s sarcoma

Abstract: MR imaging is helpful in identifying the nature of abnormal signal areas surrounding bone sarcomas that are more likely to be tumor-free, particularly when the signal in the soft tissues surrounding the tumor is feathery and edema-like in appearance.

Cited by 15 publications

References 19 publications

Osteosarcoma: Review of the Various Types with Emphasis on Recent Advancements in Imaging

Osteosarcoma: Review of the Various Types with Emphasis on Recent Advancements in Imaging

Planning for Bone Excision in Ewing Sarcoma

Preliminary clinical research on epiphyseal distraction in osteosarcoma in children

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